Protein: CDK5
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)

Gene: CDK5
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q00535

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001764 - neuron migration
GO:0001963 - synaptic transmission, dopaminergic
GO:0002039 - p53 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

960284

CD5R1
Cyclin-dependent kinase 5 activator 1

20

7

Small-scale

0.990

High

673063

CCND2
G1/S-specific cyclin-D2

12

20

Small-scale

0.985

High

804106

CDN1B
Cyclin-dependent kinase inhibitor 1B

11

20

Small-scale

0.983

High

538522

CCNB1
G2/mitotic-specific cyclin-B1

9

20

High-throughput

0.976

High

960313

CABL1
CDK5 and ABL1 enzyme substrate 1

9

8

Small-scale

0.975

High

673142

CCND3
G1/S-specific cyclin-D3

8

20

High-throughput

0.973

High

758190

CDN1A
Cyclin-dependent kinase inhibitor 1

6

20

Small-scale

0.956

High

960324

CABL2
CDK5 and ABL1 enzyme substrate 2

6

8

Small-scale

0.950

High

960282

CCNI
Cyclin-I

5

20

High-throughput

0.924

High

960080

CDK3
Cyclin-dependent kinase 3

4

17

High-throughput

0.909

High

590164

CCNA2
Cyclin-A2

4

20

High-throughput

0.903

High

622429

CCND1
G1/S-specific cyclin-D1

4

20

High-throughput

0.892

High

227181

PRKN
E3 ubiquitin-protein ligase parkin

3

11

Small-scale

0.865

High

300634

CDK14
Cyclin-dependent kinase 14

3

16

High-throughput

0.861

High

624575

CCNE1
G1/S-specific cyclin-E1

3

20

High-throughput

0.861

High

960297

CCNI2
Cyclin-I2

3

20

High-throughput

0.861

High

960308

CDK20
Cyclin-dependent kinase 20

3

15

High-throughput

0.861

High

960287

CDC37
Hsp90 co-chaperone Cdc37

2

6

High-throughput

0.817

High

960326

DCLK3
Serine/threonine-protein kinase DCLK3

2

11

High-throughput

0.811

High

960269

CDK16
Cyclin-dependent kinase 16

2

16

Small-scale

0.799

High

960292

SPDYA
Speedy protein A

2

17

High-throughput

0.783

High

960325

CNPD1
Protein CNPPD1

2

0

High-throughput

0.770

High

673469

MPIP2
M-phase inducer phosphatase 2

2

18

Small-scale

0.768

High

64007

SPDE4
Speedy protein E4

3

17

High-throughput

0.768

High

496859

TAU
Microtubule-associated protein tau

13

7

Small-scale

0.761

High

960303

C2CD5
C2 domain-containing protein 5

8

3

High-throughput

0.754

High

960298

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

Small-scale

0.747

High

960293

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

12

Small-scale

0.737

High

960278

PAK1
Serine/threonine-protein kinase PAK 1

1

11

Small-scale

0.724

High

960276

TMM94
Transmembrane protein 94

5

1

High-throughput

0.722

High

203295

FIBP
Acidic fibroblast growth factor intracellular-binding protein

8

0

High-throughput

0.722

High

740501

PPARG
Peroxisome proliferator-activated receptor gamma

4

9

Small-scale

0.699

High

960349

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

11

High-throughput

0.698

High

431743

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

438077

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

610206

CCNO
Cyclin-O

1

20

High-throughput

0.691

High

625365

CDK2
Cyclin-dependent kinase 2

1

17

High-throughput

0.691

High

960148

CDK6
Cyclin-dependent kinase 6

1

17

High-throughput

0.691

High

960274

FAK1
Focal adhesion kinase 1

1

13

High-throughput

0.691

High

960275

CDK18
Cyclin-dependent kinase 18

1

16

High-throughput

0.691

High

960277

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

9

High-throughput

0.691

High

960312

MK15
Mitogen-activated protein kinase 15

1

18

High-throughput

0.691

High

960346

AURKC
Aurora kinase C

1

8

High-throughput

0.691

High

960270

H11
Histone H1.1

4

20

Small-scale

0.686

High

960307

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

Small-scale

0.680

High

826623

TCPG
T-complex protein 1 subunit gamma

3

19

High-throughput

0.675

High

842832

TCPQ
T-complex protein 1 subunit theta

3

20

High-throughput

0.675

High

843162

TCPD
T-complex protein 1 subunit delta

3

15

High-throughput

0.675

High

960322

TCPH
T-complex protein 1 subunit eta

3

19

High-throughput

0.675

High

960310

MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

1

2

High-throughput

0.665

High

896724

ARP3
Actin-related protein 3

1

6

High-throughput

0.665

High

960344

FZR1
Fizzy-related protein homolog

3

16

Small-scale

0.664

High

517199

PCNA
Proliferating cell nuclear antigen

3

6

Small-scale

0.656

High

673389

MPIP1
M-phase inducer phosphatase 1

1

18

Small-scale

0.647

High

673567

MPIP3
M-phase inducer phosphatase 3

1

18

Small-scale

0.647

High

960273

DYN1
Dynamin-1

1

3

Small-scale

0.647

High

573225

TCPA
T-complex protein 1 subunit alpha

2

16

High-throughput

0.628

High

770793

TCPZ
T-complex protein 1 subunit zeta

2

14

High-throughput

0.628

High

821173

TCPE
T-complex protein 1 subunit epsilon

2

19

High-throughput

0.628

High

943194

TCPB
T-complex protein 1 subunit beta

2

19

High-throughput

0.628

High

821754

NEST
Nestin

2

20

Small-scale

0.624

High

803487

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.621

High

960343

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.618

High

120390

RHOD
Rho-related GTP-binding protein RhoD

1

13

High-throughput

0.618

High

161647

GAK
Cyclin-G-associated kinase

1

7

Small-scale

0.618

High

277494

CCNK
Cyclin-K

1

20

High-throughput

0.618

High

303843

CCNB2
G2/mitotic-specific cyclin-B2

1

20

High-throughput

0.618

High

338286

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.618

High

348617

RASN
GTPase NRas

1

13

High-throughput

0.618

High

384655

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

545324

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.618

High

564480

RHOQ
Rho-related GTP-binding protein RhoQ

1

11

High-throughput

0.618

High

624423

CCNC
Cyclin-C

1

20

High-throughput

0.618

High

706797

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

20

High-throughput

0.618

High

779248

CCNF
Cyclin-F

1

20

High-throughput

0.618

High

793276

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

835661

GSK3B
Glycogen synthase kinase-3 beta

1

19

Small-scale

0.618

High

841166

CDK7
Cyclin-dependent kinase 7

1

16

High-throughput

0.618

High

852435

RND2
Rho-related GTP-binding protein RhoN

1

15

High-throughput

0.618

High

892319

RAC3
Ras-related C3 botulinum toxin substrate 3

1

9

High-throughput

0.618

High

893906

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.618

High

895414

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

20

High-throughput

0.618

High

900381

RHOA
Transforming protein RhoA

1

10

High-throughput

0.618

High

901124

RND3
Rho-related GTP-binding protein RhoE

1

15

High-throughput

0.618

High

915609

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.618

High

925197

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.618

High

950926

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.618

High

960268

CDK5
Cyclin-dependent kinase 5

1

16

High-throughput

0.618

High

960271

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

9

Small-scale

0.618

High

960281

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

Small-scale

0.618

High

960285

RHOH
Rho-related GTP-binding protein RhoH

1

12

High-throughput

0.618

High

960290

ANR55
Ankyrin repeat domain-containing protein 55

1

1

High-throughput

0.618

High

960291

LARP7
La-related protein 7

1

20

High-throughput

0.618

High

960295

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.618

High

960299

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

960301

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.618

High

960309

RPTOR
Regulatory-associated protein of mTOR

1

6

High-throughput

0.618

High

960315

RND1
Rho-related GTP-binding protein Rho6

1

15

High-throughput

0.618

High

960319

CHFR
E3 ubiquitin-protein ligase CHFR

1

5

Small-scale

0.618

High

960329

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.618

High

960330

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.618

High

960334

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.618

High

960339

AFF4
AF4/FMR2 family member 4

1

3

High-throughput

0.618

High

394545

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.611

High

839270

5HT6R
5-hydroxytryptamine receptor 6

1

0

Small-scale

0.586

High

960304

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.586

High

386533

P53
Cellular tumor antigen p53

1

6

Small-scale

0.561

High

960311

SPDE1
Speedy protein E1

1

17

Small-scale

0.553

High

808090

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

High-throughput

0.536

High

456548

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.536

High

684636

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.536

High

960305

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

960317

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

960318

RSPRY
RING finger and SPRY domain-containing protein 1

1

5

High-throughput

0.536

High

960306

TRI59
Tripartite motif-containing protein 59

1

11

Small-scale

0.528

High

563071

YBOX3
Y-box-binding protein 3

1

1

Small-scale

0.527

High

825166

RL34
Large ribosomal subunit protein eL34

1

2

Small-scale

0.527

High

834267

PSN1
Presenilin-1

1

0

High-throughput

0.518

High

960328

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

381929

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

10

High-throughput

0.515

High

923642

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.515

High

960294

Q6FHY5
MEOX2 protein

1

9

High-throughput

0.515

High

960341

HOOK1
Protein Hook homolog 1

1

15

High-throughput

0.515

High

960354

NUMBL
Numb-like protein

1

4

High-throughput

0.515

High

63165

U119B
Protein unc-119 homolog B

1

0

High-throughput

0.513

High

277236

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.513

High

335091

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.513

High

724646

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.513

High

526384

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.508

High

203915

HTRA2
Serine protease HTRA2, mitochondrial

1

2

Small-scale

0.501

High

231391

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

6

Small-scale

0.501

High

269137

DAB1
Disabled homolog 1

1

4

Small-scale

0.501

High

362077

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

414246

RB
Retinoblastoma-associated protein

1

10

Small-scale

0.501

High

426619

H10
Histone H1.0

1

8

Small-scale

0.501

High

559065

H15
Histone H1.5

1

20

Small-scale

0.501

High

827734

AMPH
Amphiphysin

1

3

Small-scale

0.501

High

905833

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

Small-scale

0.501

High

960288

STX1A
Syntaxin-1A

1

2

Small-scale

0.501

High

960289

KI26B
Kinesin-like protein KIF26B

1

10

Small-scale

0.501

High

960320

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

5

High-throughput

0.501

High

960321

CK5P2
CDK5 regulatory subunit-associated protein 2

1

18

Small-scale

0.501

High

960327

NDEL1
Nuclear distribution protein nudE-like 1

1

9

Small-scale

0.501

High

960350

FYV1
1-phosphatidylinositol 3-phosphate 5-kinase

1

18

Small-scale

0.501

High

960353

TLN1
Talin-1

1

6

Small-scale

0.501

High

430925

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

4

Small-scale

0.500

High

589828

TBP
TATA-box-binding protein

1

0

High-throughput

0.493

High

618259

BDNF
Brain-derived neurotrophic factor

1

0

High-throughput

0.493

High

837930

MEOX2
Homeobox protein MOX-2

1

9

High-throughput

0.481

High

123568

PGRC1
Membrane-associated progesterone receptor component 1

1

4

Small-scale

0.479

High

241504

H2B1K
Histone H2B type 1-K

1

7

High-throughput

0.479

High

242700

IF2P
Eukaryotic translation initiation factor 5B

1

5

High-throughput

0.479

High

244291

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.479

High

262431

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

303169

HEXI1
Protein HEXIM1

1

7

High-throughput

0.479

High

489003

H14
Histone H1.4

1

20

High-throughput

0.479

High

552508

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

559654

H12
Histone H1.2

1

20

High-throughput

0.479

High

641195

DNMT1
DNA

1

8

Small-scale

0.479

High

643326

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

650972

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

719450

MERL
Merlin

1

3

High-throughput

0.479

High

720242

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

783776

GRM5
Metabotropic glutamate receptor 5

1

1

Small-scale

0.479

High

805522

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

6

Small-scale

0.479

High

828986

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

867182

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

3

High-throughput

0.479

High

880682

HDAC4
Histone deacetylase 4

1

6

Small-scale

0.479

High

901771

STXB1
Syntaxin-binding protein 1

1

2

Small-scale

0.479

High

908383

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

918294

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.479

High

948862

SARNP
SAP domain-containing ribonucleoprotein

1

2

High-throughput

0.479

High

960272

ENL
Protein ENL

1

6

High-throughput

0.479

High

960279

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.479

High

960280

SKP2
S-phase kinase-associated protein 2

1

5

High-throughput

0.479

High

960286

SEPT7
Septin-7

1

5

High-throughput

0.479

High

960302

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

960323

LZTS2
Leucine zipper putative tumor suppressor 2

1

17

High-throughput

0.479

High

960331

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

960332

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

960333

GORS2
Golgi reassembly-stacking protein 2

1

4

High-throughput

0.479

High

960336

SEP11
Septin-11

1

5

High-throughput

0.479

High

960337

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.479

High

960338

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

960340

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

1

High-throughput

0.479

High

960342

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.479

High

960345

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

Small-scale

0.479

High

960348

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.479

High

960351

RRP44
Exosome complex exonuclease RRP44

1

3

High-throughput

0.479

High

960352

SHLB1
Endophilin-B1

1

2

High-throughput

0.479

High

352068

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

902299

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.458

High

960283

ODFP1
Outer dense fiber protein 1

1

0

Small-scale

0.458

High

960316

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

960335

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

382391

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

960347

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

403630

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.438

High

960300

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.437

High

363509

FETUA
Alpha-2-HS-glycoprotein

1

0

High-throughput

0.279

Low

960314

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

495696

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.249

Low

960296

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024