Protein: SEC12
Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein)

Gene: SEC12, PREB
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q9HCU5

Gene Ontology (top 5):
GO:0003400 - regulation of COPII vesicle coating
GO:0003677 - DNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

271603

ICOSL
ICOS ligand

2

2

High-throughput

0.811

High

951445

SC61B
Protein transport protein Sec61 subunit beta

3

2

High-throughput

0.656

High

351969

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.618

High

762164

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.618

High

1438456

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.618

High

728434

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

High-throughput

0.618

High

728625

AKT2
RAC-beta serine/threonine-protein kinase

1

11

High-throughput

0.618

High

883333

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

10

High-throughput

0.618

High

980368

H4
Histone H4

1

9

High-throughput

0.618

High

699152

CALX
Calnexin

2

4

High-throughput

0.611

High

243000

PRKN
E3 ubiquitin-protein ligase parkin

2

18

High-throughput

0.584

High

375978

RASK
GTPase KRas

2

7

High-throughput

0.584

High

396993

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

869677

SC6A8
Sodium- and chloride-dependent creatine transporter 1

2

2

Small-scale

0.571

High

302971

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.553

High

1255637

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

1433951

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.553

High

132518

CDC7
Cell division cycle 7-related protein kinase

1

15

High-throughput

0.536

High

547342

CP19A
Aromatase

1

2

High-throughput

0.536

High

889009

TMEDA
Transmembrane emp24 domain-containing protein 10

1

6

High-throughput

0.536

High

1085388

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

18

High-throughput

0.536

High

1195390

ANO6
Anoctamin-6

1

1

High-throughput

0.536

High

1382204

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1392302

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.536

High

1439481

PCDB3
Protocadherin beta-3

1

3

High-throughput

0.536

High

1439484

SRPRB
Signal recognition particle receptor subunit beta

1

8

High-throughput

0.536

High

1004211

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.517

High

643083

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.515

High

1419699

GTPB4
GTP-binding protein 4

1

10

High-throughput

0.515

High

1439473

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.515

High

1034827

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1126367

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1213709

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.513

High

1333609

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1403501

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.513

High

1439483

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

1439485

TX264
Testis-expressed protein 264

1

0

High-throughput

0.513

High

700804

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.489

High

1181211

ANO4
Anoctamin-4

1

1

High-throughput

0.489

High

1439468

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.489

High

48805

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

126815

RHOD
Rho-related GTP-binding protein RhoD

1

11

High-throughput

0.479

High

174103

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.479

High

374212

RASN
GTPase NRas

1

8

High-throughput

0.479

High

390774

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

417772

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

418447

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

461952

HS90A
Heat shock protein HSP 90-alpha

1

12

High-throughput

0.479

High

466473

RHOC
Rho-related GTP-binding protein RhoC

1

10

High-throughput

0.479

High

468827

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.479

High

487778

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

548373

CP2C9
Cytochrome P450 2C9

1

2

High-throughput

0.479

High

581304

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

589754

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

634648

LMNB1
Lamin-B1

1

5

High-throughput

0.479

High

693098

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

696573

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

767342

MERL
Merlin

1

1

High-throughput

0.479

High

772207

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

774641

BASI
Basigin

1

1

High-throughput

0.479

High

831465

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

837854

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

880705

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

895077

EMD
Emerin

1

2

High-throughput

0.479

High

902088

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

904131

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

955626

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.479

High

962514

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

986741

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

1005121

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1015807

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.479

High

1058671

CKAP4
Cytoskeleton-associated protein 4

1

14

High-throughput

0.479

High

1067736

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

1087299

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1111716

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1125676

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

High-throughput

0.479

High

1238825

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

1245133

RHDF2
Inactive rhomboid protein 2

1

4

High-throughput

0.479

High

1249229

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1287450

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

8

High-throughput

0.479

High

1312265

MIRO2
Mitochondrial Rho GTPase 2

1

16

High-throughput

0.479

High

1337678

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1352374

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.479

High

1367336

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1383092

LRC59
Leucine-rich repeat-containing protein 59

1

6

High-throughput

0.479

High

1393718

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1395953

DNJC1
DnaJ homolog subfamily C member 1

1

9

High-throughput

0.479

High

1397447

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1401234

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1412675

ESYT1
Extended synaptotagmin-1

1

4

High-throughput

0.479

High

1414460

DERL1
Derlin-1

1

5

High-throughput

0.479

High

1421144

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

1431254

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.479

High

1431754

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.479

High

1435320

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1439463

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

1439464

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

1439466

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1439472

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1439474

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

1439476

AMFR
E3 ubiquitin-protein ligase AMFR

1

10

High-throughput

0.479

High

1439477

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

847703

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1204901

MKS3
Meckelin

1

0

High-throughput

0.458

High

1288502

LBN
Limbin

1

0

High-throughput

0.458

High

1403793

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1404223

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1436318

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1439462

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1439467

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1439469

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1439471

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

722627

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.445

High

844871

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

870316

S6A12
Sodium- and chloride-dependent betaine transporter

1

2

High-throughput

0.445

High

870421

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

2

High-throughput

0.445

High

1031867

LAT1
Large neutral amino acids transporter small subunit 1

1

5

High-throughput

0.445

High

1060395

SLC31
Amino acid transporter heavy chain SLC3A1

1

1

High-throughput

0.445

High

1131620

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1236328

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1242235

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.445

High

1335730

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.445

High

1363456

S39A7
Zinc transporter SLC39A7

1

5

High-throughput

0.445

High

1399548

MIA2
Melanoma inhibitory activity protein 2

1

20

High-throughput

0.445

High

1430962

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.445

High

1439480

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

189860

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

294360

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

377733

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

580703

AMPN
Aminopeptidase N

1

1

High-throughput

0.437

High

611364

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

4

High-throughput

0.437

High

630640

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.437

High

630984

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.437

High

715790

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.437

High

769241

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

901056

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.437

High

901589

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.437

High

1027189

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.437

High

1145123

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.437

High

1245577

Q6PK50
HSP90AB1 protein

1

13

High-throughput

0.437

High

1286915

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1293162

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1293671

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1312607

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.437

High

1323000

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1333341

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

1334010

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.437

High

1360940

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

1383250

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.437

High

1389391

RNF31
E3 ubiquitin-protein ligase RNF31

1

11

High-throughput

0.437

High

1392471

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1399101

SCLT1
Sodium channel and clathrin linker 1

1

18

High-throughput

0.437

High

1439478

ALK
ALK tyrosine kinase receptor

1

18

High-throughput

0.437

High

1439479

NUDC
Nuclear migration protein nudC

1

10

High-throughput

0.437

High

256161

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

548123

PSPC
Surfactant protein C

1

0

High-throughput

0.426

High

1348062

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

1439122

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

1132

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

653584

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

912717

CTR2
Cationic amino acid transporter 2

1

5

High-throughput

0.407

High

1197890

S39AC
Zinc transporter ZIP12

1

5

High-throughput

0.407

High

1242942

S39A4
Zinc transporter ZIP4

1

5

High-throughput

0.407

High

1251807

S39A5
Zinc transporter ZIP5

1

5

High-throughput

0.407

High

1340567

MFSD8
Major facilitator superfamily domain-containing protein 8

1

1

High-throughput

0.407

High

1348640

S7A14
Solute carrier family 7 member 14

1

5

High-throughput

0.407

High

1361314

CTR3
Cationic amino acid transporter 3

1

5

High-throughput

0.407

High

1401546

S26A8
Testis anion transporter 1

1

1

High-throughput

0.407

High

1439475

LAT2
Large neutral amino acids transporter small subunit 2

1

5

High-throughput

0.407

High

1439482

PCDGH
Protocadherin gamma-B5

1

3

High-throughput

0.407

High

1159863

OCLN
Occludin

2

0

High-throughput

0.328

High

260965

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

388147

ACHA
Acetylcholine receptor subunit alpha

1

0

High-throughput

0.279

Low

1203799

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1310430

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1435011

TM231
Transmembrane protein 231

1

0

High-throughput

0.279

Low

1178393

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1339185

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1382948

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1439465

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1439470

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

1308981

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025