Protein: MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)

Gene: MA1B1, MAN1B1
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9UKM7

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1365531

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

4

High-throughput

0.618

High

1163825

PTPRO
Receptor-type tyrosine-protein phosphatase O

2

1

High-throughput

0.584

High

1245944

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.576

High

397184

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

1433351

GLP3L
Golgi phosphoprotein 3-like

1

1

Small-scale

0.561

High

1433374

GOLP3
Golgi phosphoprotein 3

1

1

Small-scale

0.561

High

182826

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

271604

ICOSL
ICOS ligand

1

2

High-throughput

0.536

High

380668

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.536

High

476059

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

High-throughput

0.536

High

519678

LYAG
Lysosomal alpha-glucosidase

1

1

High-throughput

0.536

High

1034847

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.536

High

1434669

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

1461159

PCDB7
Protocadherin beta-7

1

1

High-throughput

0.536

High

1461160

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.536

High

1461163

TX264
Testis-expressed protein 264

1

1

High-throughput

0.536

High

939987

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.513

High

956121

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.513

High

1126385

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1363252

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1461158

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.513

High

896927

DYN2
Dynamin-2

1

1

High-throughput

0.508

High

575709

GPIX
Platelet glycoprotein IX

1

3

High-throughput

0.489

High

841595

I12R1
Interleukin-12 receptor subunit beta-1

1

1

High-throughput

0.489

High

1370608

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.489

High

1432201

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.489

High

1461161

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

218938

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

714509

PML
Protein PML

1

3

High-throughput

0.479

High

1026275

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

1249316

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1308239

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1448851

TMPS4
Transmembrane protease serine 4

1

7

High-throughput

0.479

High

869692

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

Small-scale

0.458

High

993086

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.458

High

993377

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.458

High

1138739

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

276643

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.445

High

538819

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.445

High

564538

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

1197906

S39AC
Zinc transporter ZIP12

1

10

High-throughput

0.445

High

1239564

ZNT6
Zinc transporter 6

1

2

High-throughput

0.445

High

1271284

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.445

High

1273824

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1310977

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

2

High-throughput

0.445

High

1323782

S39AB
Zinc transporter ZIP11

1

10

High-throughput

0.445

High

1461156

S12A4
Solute carrier family 12 member 4

1

1

High-throughput

0.445

High

1461157

S22AD
Solute carrier family 22 member 13

1

3

High-throughput

0.445

High

294511

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

580720

AMPN
Aminopeptidase N

1

2

High-throughput

0.437

High

1221032

FBW10
F-box/WD repeat-containing protein 10

1

2

High-throughput

0.437

High

1256036

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1367552

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

844896

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

1133813

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.426

High

652265

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

332599

CCDB1
Cyclin-D1-binding protein 1

3

0

High-throughput

0.347

High

251267

RNBP6
Ran-binding protein 6

2

0

High-throughput

0.328

High

821783

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

749419

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

765176

IL13
Interleukin-13

1

0

High-throughput

0.279

Low

1116117

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.279

Low

1350913

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1371895

CUL5
Cullin-5

1

0

High-throughput

0.279

Low

1428333

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.279

Low

1434770

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1446721

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1461162

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

106828

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

831627

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1368669

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.249

Low

1459261

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

839641

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

993914

TYB10
Thymosin beta-10

1

0

High-throughput

0.232

Low

1153458

CD226
CD226 antigen

1

0

High-throughput

0.232

Low

1157207

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

1390901

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025