Protein: PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)

Gene: PDE2A
Organism: Homo sapiens
Interactions: 131
UniProt ID: O00408

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0003170 - heart valve development
GO:0003281 - ventricular septum development
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

133702

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

2

6

Small-scale

0.802

High

133813

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

133774

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.547

High

133749

ITSN1
Intersectin-1

1

2

High-throughput

0.541

High

124684

AIP
AH receptor-interacting protein

1

5

Small-scale

0.529

High

63151

VP37C
Vacuolar protein sorting-associated protein 37C

1

2

High-throughput

0.479

High

104809

APRIO
Alternative prion protein

1

2

High-throughput

0.479

High

133703

SDCB1
Syntenin-1

1

4

High-throughput

0.479

High

133705

APAF
Apoptotic protease-activating factor 1

1

5

High-throughput

0.479

High

133707

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.479

High

133709

MRP5
ATP-binding cassette sub-family C member 5

1

1

High-throughput

0.479

High

133711

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

1

1

High-throughput

0.479

High

133718

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.479

High

133730

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

133731

MRP1
Multidrug resistance-associated protein 1

1

1

High-throughput

0.479

High

133734

CAV2
Caveolin-2

1

1

High-throughput

0.479

High

133738

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

133741

EPS8
Epidermal growth factor receptor kinase substrate 8

1

2

High-throughput

0.479

High

133744

TMED1
Transmembrane emp24 domain-containing protein 1

1

1

High-throughput

0.479

High

133750

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

133765

MON2
Protein MON2 homolog

1

1

High-throughput

0.479

High

133767

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

133775

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

High-throughput

0.479

High

133783

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

5

High-throughput

0.479

High

133787

TTC1
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.479

High

133792

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

High-throughput

0.479

High

133803

PLS3
Phospholipid scramblase 3

1

1

High-throughput

0.479

High

133806

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.479

High

133810

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.479

High

133812

Z3H7B
Zinc finger CCCH domain-containing protein 7B

1

1

High-throughput

0.479

High

133814

S12A6
Solute carrier family 12 member 6

1

1

High-throughput

0.479

High

133819

S12A4
Solute carrier family 12 member 4

1

1

High-throughput

0.479

High

133820

BAIP2
BAR/IMD domain-containing adapter protein 2

1

3

High-throughput

0.479

High

133822

TMED5
Transmembrane emp24 domain-containing protein 5

1

1

High-throughput

0.479

High

63803

PEDS1
Plasmanylethanolamine desaturase 1

1

0

High-throughput

0.458

High

133704

STX16
Syntaxin-16

1

0

High-throughput

0.458

High

133706

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

133708

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.458

High

133710

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.458

High

133712

ATP9B
Probable phospholipid-transporting ATPase IIB

1

0

High-throughput

0.458

High

133713

STX10
Syntaxin-10

1

0

High-throughput

0.458

High

133714

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.458

High

133716

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

133717

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.458

High

133720

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

133721

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.458

High

133724

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.458

High

133728

PEX2
Peroxisome biogenesis factor 2

1

0

High-throughput

0.458

High

133733

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

133735

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.458

High

133736

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.458

High

133739

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.458

High

133740

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.458

High

133743

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

133746

DAZP2
DAZ-associated protein 2

1

0

High-throughput

0.458

High

133748

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

133751

ANO6
Anoctamin-6

1

0

High-throughput

0.458

High

133756

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.458

High

133757

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.458

High

133758

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

0

High-throughput

0.458

High

133761

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

133762

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

133764

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

133768

RELL1
RELT-like protein 1

1

0

High-throughput

0.458

High

133769

ORML3
ORM1-like protein 3

1

0

High-throughput

0.458

High

133770

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.458

High

133773

RDH13
Retinol dehydrogenase 13

1

0

High-throughput

0.458

High

133776

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.458

High

133777

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

133778

MARC2
Mitochondrial amidoxime reducing component 2

1

0

High-throughput

0.458

High

133780

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.458

High

133784

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.458

High

133785

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

133788

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

133789

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.458

High

133791

SFXN3
Sideroflexin-3

1

0

High-throughput

0.458

High

133793

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.458

High

133794

MFF
Mitochondrial fission factor

1

0

High-throughput

0.458

High

133795

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.458

High

133796

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.458

High

133797

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

133798

MB12B
Multivesicular body subunit 12B

1

0

High-throughput

0.458

High

133799

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.458

High

133800

RN121
E3 ubiquitin ligase RNF121

1

0

High-throughput

0.458

High

133801

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.458

High

133802

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

0

High-throughput

0.458

High

133804

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.458

High

133807

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

133808

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

133809

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.458

High

133811

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

133815

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.458

High

133816

MYH2
Myosin-2

1

0

High-throughput

0.458

High

133817

TAOK2
Serine/threonine-protein kinase TAO2

1

0

High-throughput

0.458

High

133821

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.458

High

133823

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.458

High

133824

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

133825

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

133725

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.445

High

133727

ACKR3
Atypical chemokine receptor 3

1

1

High-throughput

0.445

High

133729

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.445

High

133732

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.445

High

133742

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.445

High

133755

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

2

High-throughput

0.445

High

133754

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.438

High

133805

S38A7
Sodium-coupled neutral amino acid transporter 7

1

2

High-throughput

0.437

High

133826

FADS3
Fatty acid desaturase 3

1

1

High-throughput

0.437

High

50435

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

133726

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

133737

DEF5
Defensin alpha 5

1

0

High-throughput

0.426

High

133747

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

133772

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.426

High

133781

FAF2
FAS-associated factor 2

1

0

High-throughput

0.426

High

133786

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

133818

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

133715

PRAF2
PRA1 family protein 2

1

0

High-throughput

0.249

Low

133719

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.249

Low

133723

COBA1

1

0

High-throughput

0.249

Low

133745

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.249

Low

133752

PPM1L
Protein phosphatase 1L

1

0

High-throughput

0.249

Low

133753

SLX4I
Protein SLX4IP

1

0

Small-scale

0.249

Low

133759

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.249

Low

133760

CP20A
Cytochrome P450 20A1

1

0

High-throughput

0.249

Low

133763

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.249

Low

133771

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

133779

CC127
Coiled-coil domain-containing protein 127

1

0

High-throughput

0.249

Low

133722

GROA
Growth-regulated alpha protein

1

0

High-throughput

0.232

Low

133766

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

133782

BSCL2
Seipin

1

0

High-throughput

0.232

Low

133790

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025