Protein: I22R1
Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)

Gene: I22R1, IL22RA1
Organism: Homo sapiens
Interactions: 31
UniProt ID: Q8N6P7

Gene Ontology (top 5):
GO:0004896 - cytokine receptor activity
GO:0004904 - interferon receptor activity
GO:0005886 - plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
GO:0042015 - interleukin-20 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1329601

IL22
Interleukin-22

7

4

Small-scale

0.967

High

1249951

I20RB
Interleukin-20 receptor subunit beta

2

11

Small-scale

0.754

High

827846

STAT3
Signal transducer and activator of transcription 3

3

14

Small-scale

0.661

High

1062962

I10R2
Interleukin-10 receptor subunit beta

1

11

Small-scale

0.618

High

1329600

I22R2
Interleukin-22 receptor subunit alpha-2

1

10

Small-scale

0.618

High

1329604

IL20
Interleukin-20

1

8

Small-scale

0.553

High

1329605

NB5R1
NADH-cytochrome b5 reductase 1

1

1

High-throughput

0.536

High

261222

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.513

High

324358

SLIK5
SLIT and NTRK-like protein 5

1

0

High-throughput

0.513

High

1329598

JPH3
Junctophilin-3

1

0

High-throughput

0.493

High

72665

UPK3L
Uroplakin-3b-like protein 1

1

1

High-throughput

0.489

High

297061

DHRS3
Short-chain dehydrogenase/reductase 3

1

2

High-throughput

0.489

High

337958

CNEP1
CTD nuclear envelope phosphatase 1

1

1

High-throughput

0.489

High

1242478

NFRKB
Nuclear factor related to kappa-B-binding protein

1

2

High-throughput

0.489

High

1329602

AT132
Polyamine-transporting ATPase 13A2

1

3

High-throughput

0.489

High

1329608

DHRS7
Dehydrogenase/reductase SDR family member 7

1

2

High-throughput

0.489

High

1053700

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

6

Small-scale

0.479

High

1250977

FBW12
F-box/WD repeat-containing protein 12

1

0

Small-scale

0.292

High

450256

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

790161

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.279

Low

1164133

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.279

Low

1214100

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1238350

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.279

Low

1324298

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.279

Low

1329596

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

1329597

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.279

Low

1329599

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

0

High-throughput

0.279

Low

1329603

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

0

High-throughput

0.279

Low

1329606

CCPG1
Cell cycle progression protein 1

1

0

High-throughput

0.279

Low

1329607

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.279

Low

1095416

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025