Protein: HYEP
Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH)

Gene: HYEP, EPHX1
Organism: Homo sapiens
Interactions: 96
UniProt ID: P07099

Gene Ontology (top 5):
GO:0004301 - epoxide hydrolase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006805 - xenobiotic metabolic process
GO:0008142 - oxysterol binding
GO:0009636 - response to toxic substance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

450292

SRPRB
Signal recognition particle receptor subunit beta

3

0

High-throughput

0.638

High

450266

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

3

High-throughput

0.574

High

450284

PCDGG
Protocadherin gamma-B4

2

4

High-throughput

0.574

High

450291

PCDG5
Protocadherin gamma-A5

2

4

High-throughput

0.574

High

240503

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

450223

PE2R3
Prostaglandin E2 receptor EP3 subtype

2

2

High-throughput

0.558

High

450211

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.536

High

450209

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

450212

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.517

High

450238

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

450249

SHSA2
Protein shisa-2 homolog

1

0

High-throughput

0.513

High

450267

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.513

High

450268

DERL1
Derlin-1

1

0

High-throughput

0.513

High

450276

RTN4
Reticulon-4

1

0

High-throughput

0.513

High

450277

CP26B
Cytochrome P450 26B1

1

0

High-throughput

0.513

High

450233

ACHD
Acetylcholine receptor subunit delta

1

1

High-throughput

0.489

High

450236

KCNC3
Voltage-gated potassium channel KCNC3

1

3

High-throughput

0.489

High

450288

PCDB3
Protocadherin beta-3

1

4

High-throughput

0.489

High

450289

PCDGL
Protocadherin gamma-C4

1

4

High-throughput

0.489

High

450290

PCDGH
Protocadherin gamma-B5

1

4

High-throughput

0.489

High

450206

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

450261

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

1

High-throughput

0.479

High

450228

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

450239

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

450259

RN139
E3 ubiquitin-protein ligase RNF139

1

0

High-throughput

0.458

High

425256

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.437

High

450213

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

450283

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

1

High-throughput

0.437

High

450243

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

450285

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

212369

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.347

High

450264

TSN17
Tetraspanin-17

3

0

High-throughput

0.347

High

450258

MFSD8
Major facilitator superfamily domain-containing protein 8

3

0

High-throughput

0.345

High

450234

TRAF1
TNF receptor-associated factor 1

2

0

High-throughput

0.328

High

450230

EVA1C
Protein eva-1 homolog C

2

0

High-throughput

0.318

High

450240

EREP1
Endosomal transmembrane epsin interactor 1

2

0

High-throughput

0.318

High

450271

RAB34
Ras-related protein Rab-34

2

0

High-throughput

0.318

High

450279

CC50A
Cell cycle control protein 50A

2

0

High-throughput

0.318

High

49768

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

221077

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.279

Low

450217

PTAFR
Platelet-activating factor receptor

1

0

High-throughput

0.279

Low

450222

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.279

Low

450232

GABT
4-aminobutyrate aminotransferase, mitochondrial

1

0

High-throughput

0.279

Low

450237

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.279

Low

450244

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

450246

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

450256

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

450257

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

450260

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

450262

OPTN
Optineurin

1

0

High-throughput

0.279

Low

450263

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

450270

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

450272

NMUR2
Neuromedin-U receptor 2

1

0

High-throughput

0.279

Low

450273

RXFP1
Relaxin receptor 1

1

0

High-throughput

0.279

Low

450274

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.279

Low

450275

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

450280

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

450281

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

450286

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

450254

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.269

Low

450216

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.268

Low

105132

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

178148

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

217720

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

403738

GCR
Glucocorticoid receptor

1

0

Small-scale

0.249

Low

450208

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

450210

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

450215

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.249

Low

450218

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.249

Low

450219

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

450220

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

450221

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

450226

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

Small-scale

0.249

Low

450227

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

450229

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

450231

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

450235

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

450241

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

450247

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.249

Low

450248

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

450250

DHR13
Dehydrogenase/reductase SDR family member 13

1

0

High-throughput

0.249

Low

450251

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

450252

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

450253

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

450255

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.249

Low

450265

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

450282

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

450287

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

450207

NARR
Ras-related protein Rab-34, isoform NARR

1

0

High-throughput

0.232

Low

450214

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

450224

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.232

Low

450225

SL9A3
Sodium/hydrogen exchanger 3

1

0

High-throughput

0.232

Low

450242

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

450245

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low

450269

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

450278

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025