Protein: TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein)

Gene: TYW1
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q9NV66

Gene Ontology (top 5):
GO:0010181 - FMN binding
GO:0031591 - wybutosine biosynthetic process
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0102521 - tRNA-4-demethylwyosine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1339400

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.679

High

1043872

KCNC4
Voltage-gated potassium channel KCNC4

2

1

High-throughput

0.628

High

295642

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.618

High

547343

CP19A
Aromatase

1

5

High-throughput

0.618

High

212496

SPIT2
Kunitz-type protease inhibitor 2

3

1

High-throughput

0.609

High

946598

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.609

High

1270290

BT2A1
Butyrophilin subfamily 2 member A1

3

4

High-throughput

0.609

High

1390948

TSN17
Tetraspanin-17

3

3

High-throughput

0.609

High

1180412

KLH40
Kelch-like protein 40

2

2

High-throughput

0.574

High

1250234

DLK2
Protein delta homolog 2

2

2

High-throughput

0.574

High

1288339

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

2

High-throughput

0.574

High

1332623

I17RC
Interleukin-17 receptor C

2

2

High-throughput

0.574

High

1359364

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

3

High-throughput

0.574

High

1409923

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

1

High-throughput

0.574

High

1448682

I17RB
Interleukin-17 receptor B

2

1

High-throughput

0.574

High

1450264

PCDGG
Protocadherin gamma-B4

2

5

High-throughput

0.574

High

1450273

PCDA3
Protocadherin alpha-3

2

4

High-throughput

0.574

High

303196

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.558

High

1161858

AMHR2
Anti-Muellerian hormone type-2 receptor

1

2

High-throughput

0.536

High

1337766

ACV1C
Activin receptor type-1C

1

2

High-throughput

0.536

High

1434754

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

1438487

RXFP1
Relaxin receptor 1

1

3

High-throughput

0.536

High

1450267

CIA2B
Cytosolic iron-sulfur assembly component 2B

2

1

Small-scale

0.521

High

302982

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.517

High

182799

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

349592

TSN15
Tetraspanin-15

1

3

High-throughput

0.489

High

572958

INSRR
Insulin receptor-related protein

1

2

High-throughput

0.489

High

622113

CD53
Leukocyte surface antigen CD53

1

3

High-throughput

0.489

High

731900

CEAM8
Cell adhesion molecule CEACAM8

1

2

High-throughput

0.489

High

848730

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

936131

PAR2
Proteinase-activated receptor 2

1

2

High-throughput

0.489

High

944933

TMPS3
Transmembrane protease serine 3

1

3

High-throughput

0.489

High

1085395

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

2

High-throughput

0.489

High

1126372

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.489

High

1204069

UROL1
Uromodulin-like 1

1

1

High-throughput

0.489

High

1249765

BTNL3
Butyrophilin-like protein 3

1

4

High-throughput

0.489

High

1382215

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.489

High

1390360

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

1392307

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

1416691

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.489

High

1430802

PCDC1
Protocadherin alpha-C1

1

6

High-throughput

0.489

High

1450261

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

1450265

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

1

High-throughput

0.489

High

1450268

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.489

High

1450269

PCDB3
Protocadherin beta-3

1

5

High-throughput

0.489

High

1450270

PCDGL
Protocadherin gamma-C4

1

6

High-throughput

0.489

High

1450271

PCDGH
Protocadherin gamma-B5

1

5

High-throughput

0.489

High

1450272

PCDG5
Protocadherin gamma-A5

1

5

High-throughput

0.489

High

844881

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.445

High

845152

EAA3
Excitatory amino acid transporter 3

1

3

High-throughput

0.445

High

876444

EAA4
Excitatory amino acid transporter 4

1

3

High-throughput

0.445

High

174119

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.437

High

212910

LRRT2
Leucine-rich repeat transmembrane neuronal protein 2

1

3

High-throughput

0.437

High

218837

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

417796

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.437

High

418465

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

581320

RAC2
Ras-related C3 botulinum toxin substrate 2

1

14

High-throughput

0.437

High

820760

CEAM6
Cell adhesion molecule CEACAM6

1

2

High-throughput

0.437

High

837868

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

847714

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

895101

EMD
Emerin

1

2

High-throughput

0.437

High

901606

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.437

High

904151

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.437

High

951462

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

955658

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.437

High

962544

RHOA
Transforming protein RhoA

1

15

High-throughput

0.437

High

1015834

RHOG
Rho-related GTP-binding protein RhoG

1

14

High-throughput

0.437

High

1058684

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.437

High

1111726

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.437

High

1252254

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1334027

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.437

High

1383109

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.437

High

1395963

DNJC1
DnaJ homolog subfamily C member 1

1

4

High-throughput

0.437

High

1404237

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1414473

DERL1
Derlin-1

1

2

High-throughput

0.437

High

1421155

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.437

High

1436335

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.437

High

1448153

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1450105

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1450263

XPO7
Exportin-7

1

1

High-throughput

0.437

High

50126

S22AN
Solute carrier family 22 member 23

1

2

High-throughput

0.407

High

75586

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

877722

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

1133809

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.407

High

1291910

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.407

High

1310963

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

1400634

B3A4
Anion exchange protein 4

1

1

High-throughput

0.407

High

1417618

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

1

High-throughput

0.407

High

1450262

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

1450266

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

1355939

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

0

High-throughput

0.345

High

1403591

MMS19
MMS19 nucleotide excision repair protein homolog

3

0

Small-scale

0.330

High

1395630

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.328

High

1428337

NMUR2
Neuromedin-U receptor 2

2

0

High-throughput

0.328

High

1155193

EREP1
Endosomal transmembrane epsin interactor 1

2

0

High-throughput

0.318

High

190725

MPPD1
Metallophosphoesterase domain-containing protein 1

1

0

High-throughput

0.279

Low

270178

LRP3
Low-density lipoprotein receptor-related protein 3

1

0

High-throughput

0.279

Low

483848

CD7
T-cell antigen CD7

1

0

High-throughput

0.279

Low

484229

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.279

Low

821691

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.279

Low

829929

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.279

Low

1057587

ACHD
Acetylcholine receptor subunit delta

1

0

High-throughput

0.279

Low

1187422

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

1200500

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.279

Low

1203814

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1216410

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1219680

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1329603

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

1339939

OR1M1
Olfactory receptor 1M1

1

0

High-throughput

0.279

Low

1349188

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

1357802

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1382071

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

1398912

CEP20
Centrosomal protein 20

1

0

High-throughput

0.279

Low

1419456

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

0

High-throughput

0.279

Low

1446132

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

1446711

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

463792

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.249

Low

675178

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

1309903

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low

1401242

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1417266

TMM59
Transmembrane protein 59

1

0

High-throughput

0.249

Low

296636

TNF13
Tumor necrosis factor ligand superfamily member 13

1

0

High-throughput

0.232

Low

1308300

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.232

Low

1421363

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025