Protein: CP51A
Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)

Gene: CP51A, CYP51A1
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q16850

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005789 - endoplasmic reticulum membrane
GO:0006694 - steroid biosynthetic process
GO:0006695 - cholesterol biosynthetic process
GO:0008398 - sterol 14-demethylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

547320

CP19A
Aromatase

1

13

High-throughput

0.691

High

212411

SPIT2
Kunitz-type protease inhibitor 2

4

0

High-throughput

0.661

High

506951

POTEI
POTE ankyrin domain family member I

3

0

High-throughput

0.638

High

1164181

PCDGG
Protocadherin gamma-B4

2

6

High-throughput

0.628

High

1164155

KCNKG
Potassium channel subfamily K member 16

3

0

High-throughput

0.622

High

130118

PGRC1
Membrane-associated progesterone receptor component 1

2

10

High-throughput

0.611

High

374632

RASH
GTPase HRas

2

2

High-throughput

0.611

High

1164188

PCDA3
Protocadherin alpha-3

3

3

High-throughput

0.604

High

595052

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

1

High-throughput

0.601

High

241829

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

946554

EVA1C
Protein eva-1 homolog C

2

1

High-throughput

0.571

High

1164186

PCDGH
Protocadherin gamma-B5

2

6

High-throughput

0.549

High

250094

ADCY9
Adenylate cyclase type 9

1

1

High-throughput

0.536

High

698704

CALX
Calnexin

1

1

High-throughput

0.536

High

889992

PSN1
Presenilin-1

1

2

High-throughput

0.536

High

1085320

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

3

High-throughput

0.536

High

1126292

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

1164107

PTHD3
Patched domain-containing protein 3

1

3

High-throughput

0.536

High

1164110

ACTBL
Beta-actin-like protein 2

1

1

High-throughput

0.536

High

1164146

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1164148

T4S18
Transmembrane 4 L6 family member 18

1

1

High-throughput

0.536

High

1164152

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.536

High

1164158

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

1

1

High-throughput

0.536

High

1164173

RTN4
Reticulon-4

1

4

High-throughput

0.536

High

1164175

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.536

High

1164184

PCDB3
Protocadherin beta-3

1

6

High-throughput

0.536

High

178631

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.513

High

376608

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

773525

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.513

High

1164144

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

1164159

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

1164168

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1164139

ZN420
Zinc finger protein 420

1

1

High-throughput

0.494

High

213685

AQP9
Aquaporin-9

1

5

High-throughput

0.489

High

248470

O10H2
Olfactory receptor 10H2

1

2

High-throughput

0.489

High

572929

INSRR
Insulin receptor-related protein

1

5

High-throughput

0.489

High

722851

SSR1
Somatostatin receptor type 1

1

2

High-throughput

0.489

High

1164111

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.489

High

1164154

NEB2
Neurabin-2

1

3

High-throughput

0.489

High

1164162

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.489

High

1164171

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.489

High

1164172

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1164178

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

1

High-throughput

0.489

High

1164183

O10H1
Olfactory receptor 10H1

1

2

High-throughput

0.489

High

1164185

PCDGL
Protocadherin gamma-C4

1

6

High-throughput

0.489

High

1164190

SNX14
Sorting nexin-14

1

2

High-throughput

0.489

High

173934

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

178280

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

373956

RASN
GTPase NRas

1

2

High-throughput

0.479

High

375561

RASK
GTPase KRas

1

2

High-throughput

0.479

High

404093

GCR
Glucocorticoid receptor

1

2

Small-scale

0.479

High

466281

RHOC
Rho-related GTP-binding protein RhoC

1

1

High-throughput

0.479

High

845428

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.479

High

894779

EMD
Emerin

1

1

High-throughput

0.479

High

962099

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1164122

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1164127

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

1164135

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1164151

RN185
E3 ubiquitin-protein ligase RNF185

1

1

Small-scale

0.479

High

1164160

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1164166

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1164167

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

4

High-throughput

0.479

High

1164189

SRPRB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.479

High

418165

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

788935

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

951174

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1136644

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.458

High

1163774

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.458

High

1164108

MBRL
Membralin

1

0

Small-scale

0.458

High

1164119

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1164129

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1164136

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1164169

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

137356

NPT4
Sodium-dependent phosphate transport protein 4

1

1

High-throughput

0.445

High

653345

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

722470

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.445

High

844784

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

876424

EAA4
Excitatory amino acid transporter 4

1

1

High-throughput

0.445

High

1164156

SL9A7
Sodium/hydrogen exchanger 7

1

1

High-throughput

0.445

High

1164163

S12A9
Solute carrier family 12 member 9

1

8

High-throughput

0.445

High

1164176

SCN3B
Sodium channel regulatory subunit beta-3

1

1

High-throughput

0.445

High

126621

RHOD
Rho-related GTP-binding protein RhoD

1

2

High-throughput

0.437

High

218236

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

400907

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.437

High

463113

YES
Tyrosine-protein kinase Yes

1

5

High-throughput

0.437

High

577443

ETS1
Protein C-ets-1

1

1

High-throughput

0.437

High

613064

EGR1
Early growth response protein 1

1

3

High-throughput

0.437

High

901266

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.437

High

1035658

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

1164120

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1164121

PAQR9
Membrane progestin receptor epsilon

1

2

Small-scale

0.437

High

1164125

PAQR2
Adiponectin receptor protein 2

1

3

Small-scale

0.437

High

1164134

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

1164165

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.437

High

1164112

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1164131

CTL3
Choline transporter-like protein 3

1

0

High-throughput

0.426

High

1164150

BSCL2
Seipin

1

0

High-throughput

0.426

High

1164170

POPD2
Popeye domain-containing protein 2

1

0

High-throughput

0.426

High

1164182

S27A5
Long-chain fatty acid transport protein 5

1

0

High-throughput

0.426

High

1130281

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.407

High

1164106

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

1

High-throughput

0.407

High

1164109

S39AC
Zinc transporter ZIP12

1

5

High-throughput

0.407

High

1164114

SL9C2
Sodium/hydrogen exchanger 11

1

1

High-throughput

0.407

High

1164118

S39A4
Zinc transporter ZIP4

1

5

High-throughput

0.407

High

1164140

S7A14
Solute carrier family 7 member 14

1

4

High-throughput

0.407

High

1164145

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

1164187

PCDG5
Protocadherin gamma-A5

1

6

High-throughput

0.407

High

1164149

TSN17
Tetraspanin-17

3

0

High-throughput

0.347

High

1164113

TRML2
Trem-like transcript 2 protein

2

0

High-throughput

0.318

High

1164137

CCNY
Cyclin-Y

2

0

High-throughput

0.318

High

1164157

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.318

High

190370

COPT1
High affinity copper uptake protein 1

2

0

High-throughput

0.313

High

1164164

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.282

High

49782

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

213148

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.279

Low

700784

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.279

Low

1124257

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.279

Low

1164115

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1164123

T150A
Transmembrane protein 150A

1

0

High-throughput

0.279

Low

1164130

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1164132

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

1164133

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

1164138

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

1164141

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

1164179

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

63882

5HT3E
5-hydroxytryptamine receptor 3E

1

0

High-throughput

0.249

Low

293762

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

372163

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

567416

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.249

Low

588819

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695592

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768316

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

830831

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

904782

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

1004635

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1155145

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

1164124

LBN
Limbin

1

0

High-throughput

0.249

Low

1164126

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1164142

MCLN3
Mucolipin-3

1

0

High-throughput

0.249

Low

1164147

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1164153

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1164174

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1164177

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1164180

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.249

Low

407176

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.232

Low

539704

ACHB
Acetylcholine receptor subunit beta

1

0

High-throughput

0.232

Low

1164116

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1164117

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1164128

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

1164143

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.232

Low

1164161

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025