Protein: MED7
Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)

Gene: MED7
Organism: Homo sapiens
Interactions: 80
UniProt ID: O43513

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219511

MED10
Mediator of RNA polymerase II transcription subunit 10

10

6

Small-scale

0.975

High

48878

MED19
Mediator of RNA polymerase II transcription subunit 19

9

1

Small-scale

0.975

High

219530

MED31
Mediator of RNA polymerase II transcription subunit 31

7

4

High-throughput

0.969

High

219485

MED21
Mediator of RNA polymerase II transcription subunit 21

7

3

Small-scale

0.965

High

219519

MED4
Mediator of RNA polymerase II transcription subunit 4

6

1

High-throughput

0.953

High

219460

MED14
Mediator of RNA polymerase II transcription subunit 14

6

5

Small-scale

0.950

High

219505

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

High-throughput

0.932

High

219521

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

High-throughput

0.932

High

219463

MED26
Mediator of RNA polymerase II transcription subunit 26

7

0

Small-scale

0.921

High

219478

CDK8
Cyclin-dependent kinase 8

10

5

Small-scale

0.755

High

219488

MED1
Mediator of RNA polymerase II transcription subunit 1

7

1

Small-scale

0.747

High

219523

MED29
Mediator of RNA polymerase II transcription subunit 29

6

1

High-throughput

0.738

High

219513

CDK19
Cyclin-dependent kinase 19

6

5

High-throughput

0.736

High

219525

MED13
Mediator of RNA polymerase II transcription subunit 13

6

2

Small-scale

0.735

High

219462

MED6
Mediator of RNA polymerase II transcription subunit 6

5

4

High-throughput

0.722

High

219493

MED27
Mediator of RNA polymerase II transcription subunit 27

5

1

High-throughput

0.722

High

219503

MED12
Mediator of RNA polymerase II transcription subunit 12

5

2

High-throughput

0.722

High

219512

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.722

High

219518

MED20
Mediator of RNA polymerase II transcription subunit 20

5

1

High-throughput

0.722

High

219524

MED11
Mediator of RNA polymerase II transcription subunit 11

5

1

High-throughput

0.722

High

219507

MED15
Mediator of RNA polymerase II transcription subunit 15

5

4

Small-scale

0.718

High

219522

MED9
Mediator of RNA polymerase II transcription subunit 9

7

0

Small-scale

0.717

High

219517

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

High-throughput

0.705

High

219461

MED24
Mediator of RNA polymerase II transcription subunit 24

4

1

High-throughput

0.699

High

219495

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

4

2

High-throughput

0.699

High

219497

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

4

2

High-throughput

0.699

High

219506

MED30
Mediator of RNA polymerase II transcription subunit 30

4

1

High-throughput

0.699

High

219527

MED23
Mediator of RNA polymerase II transcription subunit 23

4

1

High-throughput

0.699

High

219528

MED16
Mediator of RNA polymerase II transcription subunit 16

4

1

High-throughput

0.699

High

219471

CCNC
Cyclin-C

4

3

High-throughput

0.694

High

219472

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.691

High

219487

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.689

High

219496

MED25
Mediator of RNA polymerase II transcription subunit 25

2

1

Small-scale

0.611

High

219476

SRBP1
Sterol regulatory element-binding protein 1

2

0

Small-scale

0.592

High

169337

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

1

High-throughput

0.577

High

211238

RFOX2
RNA binding protein fox-1 homolog 2

1

1

High-throughput

0.541

High

219469

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.536

High

219470

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.536

High

219474

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.536

High

219481

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.536

High

219473

PML
Protein PML

1

0

High-throughput

0.518

High

219499

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

0

High-throughput

0.518

High

219500

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

219509

RHXF2
Rhox homeobox family member 2

1

0

High-throughput

0.518

High

219515

TRI15
E3 ubiquitin-protein ligase TRIM15

1

0

High-throughput

0.518

High

219533

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

219475

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

219480

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

219494

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

219498

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.513

High

219531

RN114
E3 ubiquitin-protein ligase RNF114

1

0

High-throughput

0.513

High

219465

ESR1
Estrogen receptor

1

3

Small-scale

0.501

High

219477

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

219502

ESR2
Estrogen receptor beta

1

3

Small-scale

0.501

High

219479

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.493

High

219510

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.493

High

219514

BARH1
BarH-like 1 homeobox protein

1

0

High-throughput

0.493

High

219489

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.489

High

219482

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

219483

TF65
Transcription factor p65

1

0

Small-scale

0.480

High

219526

DNM3L
DNA

1

0

Small-scale

0.480

High

219532

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

219468

VDR
Vitamin D3 receptor

1

1

Small-scale

0.479

High

219466

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

219484

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

219501

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.458

High

219508

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

95739

E5RFK5
Cyclin-C

1

3

High-throughput

0.445

High

219504

HAUS1
HAUS augmin-like complex subunit 1

1

1

High-throughput

0.439

High

219490

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

3369

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.417

High

76417

B4DUB1
cyclin-dependent kinase

1

5

High-throughput

0.407

High

219520

PRDC1
Phosphoribosyltransferase domain-containing protein 1

2

0

High-throughput

0.318

High

219529

CAB39
Calcium-binding protein 39

2

0

High-throughput

0.316

High

219486

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.282

High

219516

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.282

High

219492

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

0

High-throughput

0.279

Low

219464

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

219491

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

219467

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025