Protein: SPAG5
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)

Gene: SPAG5
Organism: Homo sapiens
Interactions: 186
UniProt ID: Q96R06

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000776 - kinetochore
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007051 - spindle organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1254491

CCHCR
Coiled-coil alpha-helical rod protein 1

4

16

High-throughput

0.698

High

985731

DEUP1
Deuterosome assembly protein 1

4

18

High-throughput

0.694

High

1077086

MARE1
Microtubule-associated protein RP/EB family member 1

4

5

Small-scale

0.694

High

928437

DYL1
Dynein light chain 1, cytoplasmic

3

4

High-throughput

0.675

High

200228

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

3

9

High-throughput

0.667

High

861897

PLK1
Serine/threonine-protein kinase PLK1

3

4

Small-scale

0.656

High

1131817

CE170
Centrosomal protein of 170 kDa

3

19

High-throughput

0.656

High

1300732

IFT57
Intraflagellar transport protein 57 homolog

3

0

High-throughput

0.638

High

241808

CCD22
Coiled-coil domain-containing protein 22

2

17

High-throughput

0.628

High

1238253

CCD89
Coiled-coil domain-containing protein 89

2

8

High-throughput

0.628

High

1254077

RHPN1
Rhophilin-1

2

5

High-throughput

0.628

High

1300724

CSN7B
COP9 signalosome complex subunit 7b

2

1

High-throughput

0.628

High

1253501

PPL13
Placental protein 13-like

3

7

High-throughput

0.616

High

256664

CLU
Clustered mitochondria protein homolog

2

7

High-throughput

0.611

High

1291278

DYL2
Dynein light chain 2, cytoplasmic

2

4

High-throughput

0.611

High

1300730

DISC1
Disrupted in schizophrenia 1 protein

2

4

High-throughput

0.606

High

129039

PLK4
Serine/threonine-protein kinase PLK4

2

19

High-throughput

0.606

High

318869

K2C75
Keratin, type II cytoskeletal 75

2

8

High-throughput

0.606

High

517780

K2C3
Keratin, type II cytoskeletal 3

2

10

High-throughput

0.606

High

874321

GEM
GTP-binding protein GEM

2

4

High-throughput

0.606

High

1081964

PKN1
Serine/threonine-protein kinase N1

2

8

High-throughput

0.606

High

50451

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.602

High

1156492

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.602

High

1300740

TSKS
Testis-specific serine kinase substrate

2

0

High-throughput

0.602

High

1300749

ORC6
Origin recognition complex subunit 6

2

0

High-throughput

0.601

High

1068875

PCM1
Pericentriolar material 1 protein

2

2

Small-scale

0.594

High

1290387

DTBP1
Dysbindin

2

0

High-throughput

0.585

High

835954

GSK3B
Glycogen synthase kinase-3 beta

2

20

High-throughput

0.584

High

1051420

DCTN1
Dynactin subunit 1

2

18

High-throughput

0.584

High

1300720

CENPH
Centromere protein H

2

0

High-throughput

0.580

High

1037531

BFSP2
Phakinin

2

20

High-throughput

0.574

High

1300718

TSYL1
Testis-specific Y-encoded-like protein 1

2

3

High-throughput

0.574

High

1300750

EMIL1
EMILIN-1

2

18

High-throughput

0.574

High

921153

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.573

High

1205202

CD20B
Cell division cycle protein 20 homolog B

1

20

High-throughput

0.573

High

1281230

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

High-throughput

0.573

High

1300722

SH24A
SH2 domain-containing protein 4A

1

18

High-throughput

0.573

High

1300746

AMOL2
Angiomotin-like protein 2

1

16

High-throughput

0.573

High

1147644

FTM
Protein fantom

2

18

High-throughput

0.571

High

175711

TRI18
E3 ubiquitin-protein ligase Midline-1

1

20

Small-scale

0.561

High

1300741

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

Small-scale

0.561

High

282364

NEBL
Nebulette

2

19

High-throughput

0.553

High

1189187

ZN572
Zinc finger protein 572

2

2

High-throughput

0.553

High

1201363

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

2

12

High-throughput

0.553

High

1293151

P121A
Nuclear envelope pore membrane protein POM 121

2

11

High-throughput

0.553

High

208288

DCX
Neuronal migration protein doublecortin

1

0

High-throughput

0.549

High

237294

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.549

High

1188181

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.549

High

1287091

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.549

High

1300731

FBX28
F-box only protein 28

1

0

High-throughput

0.549

High

1300733

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

310998

SNAPN
SNARE-associated protein Snapin

1

4

High-throughput

0.541

High

1267529

TSC1
Hamartin

1

19

High-throughput

0.541

High

1300713

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

7

High-throughput

0.541

High

1300725

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

12

High-throughput

0.541

High

280909

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.536

High

281044

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.536

High

603084

OSBP1
Oxysterol-binding protein 1

1

1

High-throughput

0.536

High

654035

MAP4
Microtubule-associated protein 4

1

18

High-throughput

0.536

High

927429

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

933935

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.536

High

1021039

BFSP1
Filensin

1

20

High-throughput

0.536

High

1189636

K1C27
Keratin, type I cytoskeletal 27

1

18

High-throughput

0.536

High

1190182

CLAP1
CLIP-associating protein 1

1

5

Small-scale

0.536

High

1229557

SYCE1
Synaptonemal complex central element protein 1

1

2

High-throughput

0.536

High

1295571

NEUL4
Neuralized-like protein 4

1

2

High-throughput

0.536

High

1297312

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

1300712

DUS16
Dual specificity protein phosphatase 16

1

10

High-throughput

0.536

High

1300715

K1C23
Keratin, type I cytoskeletal 23

1

16

High-throughput

0.536

High

1300721

RABE2
Rab GTPase-binding effector protein 2

1

16

High-throughput

0.536

High

1300727

RIC8A
Synembryn-A

1

1

High-throughput

0.536

High

1300735

ABI2
Abl interactor 2

1

20

High-throughput

0.536

High

1300714

OSBL8
Oxysterol-binding protein-related protein 8

1

1

Small-scale

0.529

High

1140011

TTC23
Tetratricopeptide repeat protein 23

1

2

High-throughput

0.523

High

1144452

TSH3
Teashirt homolog 3

1

9

High-throughput

0.523

High

1291075

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

6

High-throughput

0.523

High

1294792

RBM41
RNA-binding protein 41

1

13

High-throughput

0.523

High

1300710

PIMRE
Protein PIMREG

1

0

High-throughput

0.518

High

1101746

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1221986

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1300707

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.513

High

1300748

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.513

High

869517

ATN1
Atrophin-1

1

3

High-throughput

0.508

High

1148031

ZFY26
Zinc finger FYVE domain-containing protein 26

1

19

High-throughput

0.508

High

160722

AURKA
Aurora kinase A

1

20

Small-scale

0.506

High

415029

CDK1
Cyclin-dependent kinase 1

1

15

Small-scale

0.501

High

1300723

DCR1B
5' exonuclease Apollo

1

1

Small-scale

0.501

High

1230025

RPTOR
Regulatory-associated protein of mTOR

1

20

Small-scale

0.500

High

1300706

CK5P2
CDK5 regulatory subunit-associated protein 2

1

16

Small-scale

0.500

High

846853

SMCA2
Probable global transcription activator SNF2L2

1

14

High-throughput

0.494

High

1153106

IQCE
IQ domain-containing protein E

1

17

High-throughput

0.494

High

50964

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

19

High-throughput

0.489

High

831921

CEBPD
CCAAT/enhancer-binding protein delta

1

9

Small-scale

0.489

High

1067586

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

1076188

MED1
Mediator of RNA polymerase II transcription subunit 1

1

10

High-throughput

0.489

High

1116686

SL9C1
Solute carrier family 9 member C1

1

2

High-throughput

0.489

High

1230657

KT222
Keratin-like protein KRT222

1

20

High-throughput

0.489

High

1297603

ODAD1
Outer dynein arm-docking complex subunit 1

1

18

High-throughput

0.489

High

1300709

KXDL1
KxDL motif-containing protein 1

1

1

High-throughput

0.489

High

1300711

AN30A
Ankyrin repeat domain-containing protein 30A

1

8

High-throughput

0.489

High

1300717

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.486

High

989069

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.481

High

1300708

BARD1
BRCA1-associated RING domain protein 1

1

7

High-throughput

0.481

High

116615

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

131050

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

155088

NDC80
Kinetochore protein NDC80 homolog

1

17

High-throughput

0.479

High

232964

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.479

High

272678

OFD1
Centriole and centriolar satellite protein OFD1

1

19

High-throughput

0.479

High

408904

K1C18
Keratin, type I cytoskeletal 18

1

17

High-throughput

0.479

High

409202

K2C8
Keratin, type II cytoskeletal 8

1

8

High-throughput

0.479

High

430311

PROF1
Profilin-1

1

3

High-throughput

0.479

High

444459

K1C19
Keratin, type I cytoskeletal 19

1

15

High-throughput

0.479

High

737991

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

18

High-throughput

0.479

High

749795

BRCA1
Breast cancer type 1 susceptibility protein

1

16

High-throughput

0.479

High

779949

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

835501

GSK3A
Glycogen synthase kinase-3 alpha

1

18

High-throughput

0.479

High

840559

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

870875

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

7

Small-scale

0.479

High

998994

EP300
Histone acetyltransferase p300

1

17

High-throughput

0.479

High

1025061

REST
RE1-silencing transcription factor

1

2

High-throughput

0.479

High

1038644

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1039294

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

1042334

CUL3
Cullin-3

1

17

High-throughput

0.479

High

1064616

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1066558

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.479

High

1080761

ZYX
Zyxin

1

7

High-throughput

0.479

High

1119036

AMOT
Angiomotin

1

19

High-throughput

0.479

High

1135118

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

1164978

SAS6
Spindle assembly abnormal protein 6 homolog

1

17

High-throughput

0.479

High

1168640

SYNE3
Nesprin-3

1

19

High-throughput

0.479

High

1171324

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1200590

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1202443

HOOK3
Protein Hook homolog 3

1

18

High-throughput

0.479

High

1229836

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.479

High

1233422

NIN
Ninein

1

18

High-throughput

0.479

High

1292174

AURKB
Aurora kinase B

1

20

Small-scale

0.479

High

1300728

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

1300729

ANLN
Anillin

1

11

High-throughput

0.479

High

1300738

CEP72
Centrosomal protein of 72 kDa

1

4

Small-scale

0.479

High

1300739

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.479

High

1300742

ANC2
Anaphase-promoting complex subunit 2

1

18

High-throughput

0.479

High

1300743

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

4

High-throughput

0.479

High

1300744

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

1300745

NINL
Ninein-like protein

1

16

High-throughput

0.479

High

48078

A0AVN2
BRCA1 associated RING domain 1

1

12

High-throughput

0.470

High

102389

G3V1X1
Proline/serine-rich coiled-coil 2, isoform CRA_a

1

2

High-throughput

0.470

High

1000177

GOG8D
Putative golgin subfamily A member 8D

1

17

High-throughput

0.470

High

1234239

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

1

High-throughput

0.464

High

262075

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

1100914

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1115659

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.458

High

1300716

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

1300751

X5DP31
Aryl-hydrocarbon receptor nuclear translocator 2 isoform E

1

12

High-throughput

0.457

High

497467

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

230418

ZC3H1
Zinc finger C3H1 domain-containing protein

1

2

High-throughput

0.439

High

473707

ZN688
Zinc finger protein 688

1

3

High-throughput

0.439

High

235297

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.438

High

205859

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.437

High

232443

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.437

High

329903

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.437

High

721211

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1165876

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1188745

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1285334

PF21A
PHD finger protein 21A

1

17

High-throughput

0.437

High

1300726

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1300737

SEP10
Septin-10

1

2

High-throughput

0.437

High

3422

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

3

High-throughput

0.417

High

1034769

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

2

Small-scale

0.417

High

1221396

Q8IXW7
FMR1 protein

1

6

High-throughput

0.417

High

1091161

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1109811

C144B
Putative coiled-coil domain-containing protein 144B

1

14

High-throughput

0.407

High

1245662

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.407

High

1296672

C170L
Cep170-like protein

1

3

High-throughput

0.407

High

1292744

BORC6
BLOC-1-related complex subunit 6

4

0

High-throughput

0.362

High

58459

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

1037087

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.328

High

1300747

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

1120634

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.299

High

1131002

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.299

High

1298613

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.299

High

1300734

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.299

High

1293848

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1300719

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1300736

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

1235109

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1146091

Z385C
Zinc finger protein 385C

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024