Protein: EDC3
Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)

Gene: EDC3
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q96F86

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0003729 - mRNA binding
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0031087 - deadenylation-independent decapping of nuclear-transcribed mRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640583

DDX6
Probable ATP-dependent RNA helicase DDX6

16

2

Small-scale

0.987

High

1290978

EDC3
Enhancer of mRNA-decapping protein 3

6

2

Small-scale

0.951

High

1290995

DCP1A
mRNA-decapping enzyme 1A

15

3

Small-scale

0.764

High

1224178

DCP1B
mRNA-decapping enzyme 1B

13

3

Small-scale

0.763

High

904972

1433G
14-3-3 protein gamma

7

7

High-throughput

0.748

High

683616

1433B
14-3-3 protein beta/alpha

5

7

High-throughput

0.718

High

982373

1433F
14-3-3 protein eta

5

7

High-throughput

0.718

High

1215869

DCP2
m7GpppN-mRNA hydrolase

5

4

Small-scale

0.718

High

927395

1433Z
14-3-3 protein zeta/delta

4

7

High-throughput

0.691

High

1158992

EDC4
Enhancer of mRNA-decapping protein 4

5

0

Small-scale

0.688

High

647183

1433T
14-3-3 protein theta

4

7

High-throughput

0.687

High

507583

PIM1
Serine/threonine-protein kinase pim-1

4

0

High-throughput

0.670

High

909901

1433E
14-3-3 protein epsilon

3

1

High-throughput

0.656

High

314117

BAG4
BAG family molecular chaperone regulator 4

3

0

High-throughput

0.646

High

1242103

LS14A
Protein LSM14 homolog A

3

1

Small-scale

0.640

High

802887

CRKL
Crk-like protein

2

1

High-throughput

0.628

High

742466

SYUA
Alpha-synuclein

3

0

High-throughput

0.606

High

238985

LPXN
Leupaxin

2

0

High-throughput

0.602

High

660659

GRN
Progranulin

2

0

High-throughput

0.602

High

1024397

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

0

High-throughput

0.595

High

644307

TTP
mRNA decay activator protein ZFP36

2

0

Small-scale

0.585

High

1290988

CARD9
Caspase recruitment domain-containing protein 9

2

0

High-throughput

0.585

High

684260

1433S
14-3-3 protein sigma

2

7

High-throughput

0.584

High

835936

GSK3B
Glycogen synthase kinase-3 beta

2

2

High-throughput

0.584

High

814511

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.580

High

370188

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

802697

CRK
Adapter molecule crk

2

1

High-throughput

0.571

High

1198376

PATL1
Protein PAT1 homolog 1

2

1

Small-scale

0.571

High

228339

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

451531

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

451719

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

609999

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.536

High

863987

CLH2
Clathrin heavy chain 2

1

1

High-throughput

0.536

High

960924

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.536

High

1272296

RENT1
Regulator of nonsense transcripts 1

1

2

Small-scale

0.536

High

64063

AQ12B
Aquaporin-12B

1

0

High-throughput

0.513

High

274280

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

358863

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

881547

ARL4C
ADP-ribosylation factor-like protein 4C

1

0

High-throughput

0.513

High

1240924

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1290991

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1290996

PNRC2
Proline-rich nuclear receptor coactivator 2

1

0

High-throughput

0.513

High

1290999

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1057146

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

1

High-throughput

0.489

High

1144746

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

1

High-throughput

0.489

High

1220353

FBX16
F-box only protein 16

1

1

High-throughput

0.489

High

175110

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

163133

XPO1
Exportin-1

1

2

High-throughput

0.479

High

264376

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.479

High

301963

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

516637

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.479

High

835488

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

960400

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1031426

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.479

High

1187710

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

High-throughput

0.479

High

1224387

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

1232125

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

1242628

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

1

High-throughput

0.479

High

1262698

ATX2L
Ataxin-2-like protein

1

1

High-throughput

0.479

High

1290986

ATX2
Ataxin-2

1

1

High-throughput

0.479

High

1290987

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.479

High

1290993

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

1291010

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

2

High-throughput

0.479

High

62162

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.458

High

177072

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

0

Small-scale

0.458

High

237291

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

253392

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

322990

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

656289

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

668903

PML
Protein PML

1

0

High-throughput

0.458

High

673510

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

779904

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

902992

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.458

High

908951

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

998970

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1042263

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1060591

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1074387

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

1129425

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

0

Small-scale

0.458

High

1129579

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1136534

SPD2A
SH3 and PX domain-containing protein 2A

1

0

High-throughput

0.458

High

1140693

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1168814

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1192352

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.458

High

1200568

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1217972

KSR1
Kinase suppressor of Ras 1

1

0

High-throughput

0.458

High

1222516

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1245126

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1256244

DEN1A
DENN domain-containing protein 1A

1

0

High-throughput

0.458

High

1266647

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1271229

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.458

High

1285639

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.458

High

1290983

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1290989

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1290998

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1291002

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1291003

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

1291006

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

1291008

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1291011

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

1291012

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1291013

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1291016

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.458

High

1153334

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

1089547

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

3

High-throughput

0.437

High

1173139

SYDE1
Rho GTPase-activating protein SYDE1

1

1

High-throughput

0.437

High

1188705

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1263447

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.437

High

1269341

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1270374

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.437

High

1290984

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.437

High

1290990

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

3541

NBDY
Negative regulator of P-body association

1

0

Small-scale

0.426

High

1130435

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1290982

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.426

High

353715

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.407

High

353892

IGHG4
Immunoglobulin heavy constant gamma 4

1

1

High-throughput

0.407

High

1291005

ANX10
Annexin A10

6

0

High-throughput

0.385

High

1127574

EFHC2
EF-hand domain-containing family member C2

4

0

High-throughput

0.368

High

198461

KLK10
Kallikrein-10

3

0

High-throughput

0.347

High

1291000

TAP26
Thyroid transcription factor 1-associated protein 26

2

0

High-throughput

0.328

High

278318

PIAS2
E3 SUMO-protein ligase PIAS2

2

0

High-throughput

0.316

High

1252391

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

639935

ITB8
Integrin beta-8

1

0

High-throughput

0.279

Low

870048

LIPR2
Pancreatic lipase-related protein 2

1

0

High-throughput

0.279

Low

873468

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1147864

C102B
Coiled-coil domain-containing protein 102B

1

0

High-throughput

0.279

Low

1251127

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.279

Low

1251569

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.279

Low

1290980

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1290992

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1291004

F153A
Protein FAM153A

1

0

High-throughput

0.279

Low

1291007

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

1291015

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

101061

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

166595

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.249

Low

196490

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.249

Low

205824

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

244775

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

385333

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

553421

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

721141

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1074969

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1109618

LSM12
Protein LSM12

1

0

High-throughput

0.249

Low

1171203

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1290979

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.249

Low

1290981

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.249

Low

1290985

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.249

Low

1290994

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

1290997

KI13B
Kinesin-like protein KIF13B

1

0

High-throughput

0.249

Low

1291001

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1291009

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.249

Low

1291014

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024