Protein: CD80
T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)

Gene: CD80
Organism: Homo sapiens
Interactions: 163
UniProt ID: P33681

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0002710 - negative regulation of T cell mediated immunity
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

754114

PD1L1
Programmed cell death 1 ligand 1

6

16

Small-scale

0.947

High

532161

CD28
T-cell-specific surface glycoprotein CD28

5

9

Small-scale

0.927

High

596458

CTLA4
Cytotoxic T-lymphocyte protein 4

4

9

Small-scale

0.906

High

754006

MTOR
Serine/threonine-protein kinase mTOR

2

15

High-throughput

0.776

High

466564

TNR16
Tumor necrosis factor receptor superfamily member 16

1

5

Small-scale

0.747

High

173668

BTAF1
TATA-binding protein-associated factor 172

2

2

High-throughput

0.694

High

754046

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

2

6

High-throughput

0.694

High

316601

ST17B
Serine/threonine-protein kinase 17B

1

7

High-throughput

0.691

High

424787

ADT2
ADP/ATP translocase 2

1

6

High-throughput

0.691

High

754026

PDCD1
Programmed cell death protein 1

1

3

Small-scale

0.647

High

62912

POTEF
POTE ankyrin domain family member F

1

5

High-throughput

0.618

High

228065

PM34
Peroxisomal membrane protein PMP34

1

7

High-throughput

0.618

High

248565

FADS1
Acyl-CoA

1

2

High-throughput

0.618

High

754014

PRKDC
DNA-dependent protein kinase catalytic subunit

1

13

High-throughput

0.618

High

754019

ATM
Serine-protein kinase ATM

1

14

High-throughput

0.618

High

754022

ATR
Serine/threonine-protein kinase ATR

1

14

High-throughput

0.618

High

754037

KMCP1
Kidney mitochondrial carrier protein 1

1

6

High-throughput

0.618

High

754045

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

6

High-throughput

0.618

High

754050

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

1

High-throughput

0.618

High

754053

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

8

High-throughput

0.618

High

754011

KNTC1
Kinetochore-associated protein 1

2

1

High-throughput

0.601

High

754028

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

3

High-throughput

0.601

High

754072

EXOC6
Exocyst complex component 6

2

2

High-throughput

0.601

High

754113

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

0

High-throughput

0.578

High

754118

VATH
V-type proton ATPase subunit H

2

0

High-throughput

0.576

High

127289

LEG8
Galectin-8

1

9

High-throughput

0.575

High

441411

CHLE
Cholinesterase

1

1

High-throughput

0.575

High

480725

LEG1
Galectin-1

1

9

High-throughput

0.575

High

754005

CD80
T-lymphocyte activation antigen CD80

1

15

Small-scale

0.575

High

754061

WDFY3
WD repeat and FYVE domain-containing protein 3

1

6

High-throughput

0.575

High

754107

RAB18
Ras-related protein Rab-18

1

12

High-throughput

0.575

High

754018

VAC14
Protein VAC14 homolog

2

14

High-throughput

0.549

High

754033

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

4

High-throughput

0.549

High

754052

THADA
tRNA

2

3

High-throughput

0.549

High

754074

SFXN5
Sideroflexin-5

2

2

High-throughput

0.549

High

754078

FAKD4
FAST kinase domain-containing protein 4

2

4

High-throughput

0.549

High

754094

INT2
Integrator complex subunit 2

2

2

High-throughput

0.549

High

754110

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

5

High-throughput

0.549

High

754121

XPO7
Exportin-7

2

20

High-throughput

0.549

High

754124

BCS1
Mitochondrial chaperone BCS1

2

6

High-throughput

0.549

High

754129

TNPO3
Transportin-3

2

20

High-throughput

0.549

High

291061

UTP20
Small subunit processome component 20 homolog

1

1

High-throughput

0.536

High

637854

NF1
Neurofibromin

1

4

High-throughput

0.536

High

665070

COT2
COUP transcription factor 2

1

5

High-throughput

0.536

High

754120

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.536

High

161286

ENC1
Ectoderm-neural cortex protein 1

1

2

High-throughput

0.514

High

754007

MAGA6
Melanoma-associated antigen 6

1

2

High-throughput

0.514

High

754029

D19L1
Protein C-mannosyl-transferase DPY19L1

1

2

High-throughput

0.514

High

754039

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.514

High

754047

D19L2
Probable C-mannosyltransferase DPY19L2

1

2

High-throughput

0.514

High

754058

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

1

High-throughput

0.514

High

754067

FBCD1
Fibrinogen C domain-containing protein 1

1

3

High-throughput

0.514

High

754075

DMXL2
DmX-like protein 2

1

1

High-throughput

0.514

High

754081

SMG1
Serine/threonine-protein kinase SMG1

1

13

High-throughput

0.514

High

754086

ODC
Mitochondrial 2-oxodicarboxylate carrier

1

8

High-throughput

0.514

High

754087

S2533
Solute carrier family 25 member 33

1

7

High-throughput

0.514

High

754088

LRRC1
Leucine-rich repeat-containing protein 1

1

5

High-throughput

0.514

High

754098

TMX1
Thioredoxin-related transmembrane protein 1

1

12

High-throughput

0.514

High

754041

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

0

High-throughput

0.513

High

754066

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

0

High-throughput

0.513

High

164539

TNPO2
Transportin-2

1

19

High-throughput

0.489

High

230875

ORC5
Origin recognition complex subunit 5

1

4

High-throughput

0.489

High

754013

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.489

High

754016

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

754021

TBB3
Tubulin beta-3 chain

1

8

High-throughput

0.489

High

754025

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

4

High-throughput

0.489

High

754027

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

754044

ATLA3
Atlastin-3

1

1

High-throughput

0.489

High

754051

BRAT1
Integrator complex assembly factor BRAT1

1

1

High-throughput

0.489

High

754054

5MP2
eIF5-mimic protein 2

1

6

High-throughput

0.489

High

754064

INT1
Integrator complex subunit 1

1

1

High-throughput

0.489

High

754071

NAV1
Neuron navigator 1

1

4

High-throughput

0.489

High

754079

OTUL
Ubiquitin thioesterase otulin

1

4

High-throughput

0.489

High

754091

SFXN3
Sideroflexin-3

1

2

High-throughput

0.489

High

754096

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.489

High

754100

GLP3L
Golgi phosphoprotein 3-like

1

1

High-throughput

0.489

High

271672

HIP1R
Huntingtin-interacting protein 1-related protein

1

3

High-throughput

0.445

High

297160

PRAF3
PRA1 family protein 3

1

1

High-throughput

0.445

High

642202

COMT
Catechol O-methyltransferase

1

1

High-throughput

0.445

High

754023

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

High-throughput

0.445

High

754032

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

2

High-throughput

0.445

High

754034

PKHG4
Puratrophin-1

1

5

High-throughput

0.445

High

754040

RIF1
Telomere-associated protein RIF1

1

2

High-throughput

0.445

High

754055

MIGA2
Mitoguardin 2

1

2

High-throughput

0.445

High

754063

S39AB
Zinc transporter ZIP11

1

10

High-throughput

0.445

High

754073

CIP2A
Protein CIP2A

1

7

High-throughput

0.445

High

754082

XPO6
Exportin-6

1

3

High-throughput

0.445

High

754101

GOLP3
Golgi phosphoprotein 3

1

1

High-throughput

0.445

High

231450

ORC4
Origin recognition complex subunit 4

1

4

High-throughput

0.407

High

252835

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.407

High

329134

RCBT2
RCC1 and BTB domain-containing protein 2

1

3

High-throughput

0.407

High

749592

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

1

High-throughput

0.407

High

754008

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

754009

AT5G3
ATP synthase F(0) complex subunit C3, mitochondrial

1

1

High-throughput

0.407

High

754012

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.407

High

754015

COG7
Conserved oligomeric Golgi complex subunit 7

1

2

High-throughput

0.407

High

754017

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

High-throughput

0.407

High

754024

IMB1
Importin subunit beta-1

1

15

High-throughput

0.407

High

754030

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

5

High-throughput

0.407

High

754031

AR13B
ADP-ribosylation factor-like protein 13B

1

15

High-throughput

0.407

High

754036

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

1

High-throughput

0.407

High

754057

UBE3B
Ubiquitin-protein ligase E3B

1

9

High-throughput

0.407

High

754062

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.407

High

754065

PYRD2
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

1

1

High-throughput

0.407

High

754068

ARL10
ADP-ribosylation factor-like protein 10

1

20

High-throughput

0.407

High

754070

RCBT1
RCC1 and BTB domain-containing protein 1

1

3

High-throughput

0.407

High

754076

RUFY2
RUN and FYVE domain-containing protein 2

1

10

High-throughput

0.407

High

754080

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.407

High

754089

TBB6
Tubulin beta-6 chain

1

8

High-throughput

0.407

High

754092

DERL2
Derlin-2

1

1

High-throughput

0.407

High

754099

UN45A
Protein unc-45 homolog A

1

9

High-throughput

0.407

High

754102

TBB1
Tubulin beta-1 chain

1

7

High-throughput

0.407

High

754106

EPG5
Ectopic P granules protein 5 homolog

1

1

High-throughput

0.407

High

754111

ECHD1
Ethylmalonyl-CoA decarboxylase

1

3

High-throughput

0.407

High

754112

TB22B
TBC1 domain family member 22B

1

5

High-throughput

0.407

High

754116

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.407

High

754119

IPO11
Importin-11

1

20

High-throughput

0.407

High

754122

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

5

High-throughput

0.407

High

754125

EXC6B
Exocyst complex component 6B

1

2

High-throughput

0.407

High

754127

COG6
Conserved oligomeric Golgi complex subunit 6

1

1

High-throughput

0.407

High

754128

RBGP1
Rab GTPase-activating protein 1

1

6

High-throughput

0.407

High

212936

HS12A
Heat shock 70 kDa protein 12A

2

0

High-throughput

0.313

High

319449

UFL1
E3 UFM1-protein ligase 1

2

0

High-throughput

0.313

High

754020

MTX1
Metaxin-1

2

0

High-throughput

0.313

High

754035

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

2

0

High-throughput

0.313

High

754056

DPH6
Diphthine--ammonia ligase

2

0

High-throughput

0.313

High

754059

DAAF5
Dynein axonemal assembly factor 5

2

0

High-throughput

0.313

High

754085

F118B
Protein FAM118B

2

0

High-throughput

0.313

High

754103

TFB2M
Dimethyladenosine transferase 2, mitochondrial

2

0

High-throughput

0.313

High

754109

PXMP2
Peroxisomal membrane protein 2

2

0

High-throughput

0.313

High

67358

RTL8C
Retrotransposon Gag-like protein 8C

1

0

High-throughput

0.279

Low

211737

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.279

Low

219926

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

754010

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.279

Low

754048

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

754049

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.279

Low

754104

NOL11
Nucleolar protein 11

1

0

High-throughput

0.279

Low

754105

NJMU
Protein Njmu-R1

1

0

High-throughput

0.279

Low

754126

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.279

Low

64755

RIMC1
RAB7A-interacting MON1-CCZ1 complex subunit 1

1

0

High-throughput

0.232

Low

187470

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.232

Low

193363

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

High-throughput

0.232

Low

341239

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.232

Low

442613

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.232

Low

539038

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.232

Low

697404

DCK
Deoxycytidine kinase

1

0

High-throughput

0.232

Low

754038

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

754042

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.232

Low

754043

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.232

Low

754060

F200C
Protein FAM200C

1

0

High-throughput

0.232

Low

754069

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.232

Low

754077

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.232

Low

754083

METH
Methionine synthase

1

0

High-throughput

0.232

Low

754084

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.232

Low

754090

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.232

Low

754093

SRR
Serine racemase

1

0

High-throughput

0.232

Low

754095

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.232

Low

754097

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.232

Low

754108

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.232

Low

754115

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.232

Low

754117

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.232

Low

754123

FBXL3
F-box/LRR-repeat protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025