Protein: WIPI2
WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)

Gene: WIPI2
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q9Y4P8

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000422 - autophagy of mitochondrion
GO:0000425 - pexophagy
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1227775

A16L1
Autophagy-related protein 16-1

10

20

Small-scale

0.970

High

1431361

ATG5
Autophagy protein 5

6

4

Small-scale

0.729

High

1435215

BCAS3
BCAS3 microtubule associated cell migration factor

5

10

Small-scale

0.712

High

1412909

PHAF1
Phagosome assembly factor 1

4

1

High-throughput

0.691

High

1410487

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

3

1

High-throughput

0.667

High

1419901

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

3

1

High-throughput

0.667

High

1491259

RBGP1
Rab GTPase-activating protein 1

3

2

High-throughput

0.650

High

1386647

OPTN
Optineurin

2

20

Small-scale

0.634

High

1280635

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

9

Small-scale

0.624

High

1311544

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.602

High

1460556

NAGK
N-acetyl-D-glucosamine kinase

2

0

High-throughput

0.585

High

317698

ATG12
Ubiquitin-like protein ATG12

2

1

Small-scale

0.584

High

935346

TERA
Transitional endoplasmic reticulum ATPase

2

8

Small-scale

0.584

High

1491449

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

17

High-throughput

0.575

High

1139307

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

1

High-throughput

0.573

High

1158015

DDB1
DNA damage-binding protein 1

1

14

Small-scale

0.561

High

1322685

RPTOR
Regulatory-associated protein of mTOR

1

17

Small-scale

0.561

High

1393464

REEP6
Receptor expression-enhancing protein 6

2

1

High-throughput

0.553

High

1491451

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

6

High-throughput

0.553

High

1452494

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.552

High

1450195

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.549

High

1272605

CSN6
COP9 signalosome complex subunit 6

1

4

High-throughput

0.541

High

839418

MTOR
Serine/threonine-protein kinase mTOR

1

14

Small-scale

0.536

High

679301

DNJB1
DnaJ homolog subfamily B member 1

1

12

High-throughput

0.536

High

1032572

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

7

High-throughput

0.536

High

1125426

FLNC
Filamin-C

1

18

High-throughput

0.536

High

1220510

BTBD8
BTB/POZ domain-containing protein 8

1

8

High-throughput

0.536

High

1365799

GCN1
Stalled ribosome sensor GCN1

1

20

High-throughput

0.536

High

1370499

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

1490537

NUDC
Nuclear migration protein nudC

1

20

High-throughput

0.536

High

384592

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.501

High

128092

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

Small-scale

0.479

High

158367

COPE
Coatomer subunit epsilon

1

2

Small-scale

0.479

High

193652

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

9

Small-scale

0.479

High

211093

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

243395

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

364084

EGFR
Epidermal growth factor receptor

1

14

High-throughput

0.479

High

507436

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

15

Small-scale

0.479

High

590128

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

647689

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

696967

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

769608

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

882231

TCPG
T-complex protein 1 subunit gamma

1

20

Small-scale

0.479

High

891376

GSK3A
Glycogen synthase kinase-3 alpha

1

18

High-throughput

0.479

High

891914

GSK3B
Glycogen synthase kinase-3 beta

1

16

High-throughput

0.479

High

896944

DYN2
Dynamin-2

1

4

High-throughput

0.479

High

922625

AP2S1
AP-2 complex subunit sigma

1

3

Small-scale

0.479

High

969099

PRS8
26S proteasome regulatory subunit 8

1

11

Small-scale

0.479

High

975531

PRS10
26S proteasome regulatory subunit 10B

1

11

Small-scale

0.479

High

976695

RB11A
Ras-related protein Rab-11A

1

4

Small-scale

0.479

High

1089940

ILF3
Interleukin enhancer-binding factor 3

1

12

Small-scale

0.479

High

1094450

CSN1
COP9 signalosome complex subunit 1

1

6

Small-scale

0.479

High

1115167

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1115496

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

1148970

SC23A
Protein transport protein Sec23A

1

3

Small-scale

0.479

High

1158623

CDC37
Hsp90 co-chaperone Cdc37

1

3

Small-scale

0.479

High

1363908

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1385183

ATG2B
Autophagy-related protein 2 homolog B

1

11

Small-scale

0.479

High

1412248

ATGA1
Autophagy-related protein 101

1

1

Small-scale

0.479

High

1415171

LST8
Target of rapamycin complex subunit LST8

1

17

Small-scale

0.479

High

1417333

AP1M1
AP-1 complex subunit mu-1

1

2

Small-scale

0.479

High

1429035

WWTR1
WW domain-containing transcription regulator protein 1

1

10

High-throughput

0.479

High

1490798

MYH15
Myosin-15

1

4

High-throughput

0.479

High

1118269

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

1280177

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

Small-scale

0.458

High

1347677

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

1448663

STRN4
Striatin-4

1

17

High-throughput

0.457

High

124857

AIP
AH receptor-interacting protein

1

17

High-throughput

0.445

High

348011

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.445

High

610521

PRS6A
26S proteasome regulatory subunit 6A

1

17

High-throughput

0.445

High

731736

STIP1
Stress-induced-phosphoprotein 1

1

15

High-throughput

0.445

High

916728

PPP5
Serine/threonine-protein phosphatase 5

1

13

High-throughput

0.445

High

1102935

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

18

High-throughput

0.445

High

1315560

ULK2
Serine/threonine-protein kinase ULK2

1

7

High-throughput

0.445

High

1352021

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.445

High

1363111

DDB2
DNA damage-binding protein 2

1

17

High-throughput

0.445

High

1386427

FAF2
FAS-associated factor 2

1

1

High-throughput

0.445

High

1449652

ECHD1
Ethylmalonyl-CoA decarboxylase

1

4

High-throughput

0.445

High

1458950

DNJB4
DnaJ homolog subfamily B member 4

1

13

High-throughput

0.445

High

1491450

MAGD1
Melanoma-associated antigen D1

1

9

High-throughput

0.445

High

699292

CALX
Calnexin

1

4

Small-scale

0.437

High

1256254

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1277031

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1327295

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.437

High

1460332

XPO7
Exportin-7

1

17

High-throughput

0.437

High

333733

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

1

High-throughput

0.407

High

388027

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.407

High

399650

VTNC
Vitronectin

1

1

High-throughput

0.407

High

835424

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.407

High

1361497

IFT81
Intraflagellar transport protein 81 homolog

1

20

High-throughput

0.407

High

1411438

CAB45
45 kDa calcium-binding protein

1

6

High-throughput

0.407

High

1451187

IFT57
Intraflagellar transport protein 57 homolog

1

1

High-throughput

0.407

High

1453412

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.407

High

239406

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

4

0

High-throughput

0.360

High

1460200

PRAF1
Prenylated Rab acceptor protein 1

3

0

High-throughput

0.352

High

469575

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

1253318

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

0

High-throughput

0.316

High

1388323

RRFM
Ribosome-recycling factor, mitochondrial

2

0

High-throughput

0.316

High

1403484

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

934036

PLTP
Phospholipid transfer protein

1

0

High-throughput

0.232

Low

1491385

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025