Protein: ACTS
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]

Gene: ACTS, ACTA1
Organism: Homo sapiens
Interactions: 225
UniProt ID: P68133

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0005200 - structural constituent of cytoskeleton
GO:0005524 - ATP binding
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

413886

GELS
Gelsolin

3

17

Small-scale

0.818

High

932956

CAP1
Adenylyl cyclase-associated protein 1

2

20

High-throughput

0.811

High

912805

TYB4
Thymosin beta-4

2

2

Small-scale

0.778

High

618053

COF1
Cofilin-1

2

20

Small-scale

0.768

High

364005

VTDB
Vitamin D-binding protein

2

3

Small-scale

0.755

High

507943

FGFR1
Fibroblast growth factor receptor 1

2

3

Small-scale

0.754

High

681780

AKT1
RAC-alpha serine/threonine-protein kinase

2

11

Small-scale

0.754

High

891681

ACTB
Actin, cytoplasmic 1

2

18

High-throughput

0.754

High

932962

TLE3
Transducin-like enhancer protein 3

2

7

High-throughput

0.726

High

325685

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.691

High

851444

NEK4
Serine/threonine-protein kinase Nek4

1

14

High-throughput

0.691

High

915358

ACTA
Actin, aortic smooth muscle

1

18

High-throughput

0.691

High

933037

LRCH3
DISP complex protein LRCH3

1

5

High-throughput

0.691

High

932977

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

3

1

High-throughput

0.667

High

933073

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.665

High

533971

ANXA8
Annexin A8

3

4

High-throughput

0.657

High

434371

TPM2
Tropomyosin beta chain

1

10

Small-scale

0.647

High

513848

DMD
Dystrophin

1

20

Small-scale

0.647

High

616696

KS6B1
Ribosomal protein S6 kinase beta-1

1

15

Small-scale

0.647

High

851163

CNN1
Calponin-1

1

17

Small-scale

0.647

High

932976

COTL1
Coactosin-like protein

1

11

Small-scale

0.647

High

933081

SCIN
Scinderin

1

17

Small-scale

0.647

High

932987

HIF1A
Hypoxia-inducible factor 1-alpha

2

1

High-throughput

0.628

High

933032

TRI63
E3 ubiquitin-protein ligase TRIM63

2

19

Small-scale

0.625

High

768468

CAP2
Adenylyl cyclase-associated protein 2

1

20

High-throughput

0.618

High

933021

CADM4
Cell adhesion molecule 4

1

1

High-throughput

0.618

High

117658

MYO1C
Unconventional myosin-Ic

1

11

Small-scale

0.618

High

128990

PLK4
Serine/threonine-protein kinase PLK4

1

2

Small-scale

0.618

High

255670

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.618

High

408595

KPCB
Protein kinase C beta type

1

9

Small-scale

0.618

High

625343

CDK2
Cyclin-dependent kinase 2

1

5

High-throughput

0.618

High

655311

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

16

Small-scale

0.618

High

724767

MYH9
Myosin-9

1

10

High-throughput

0.618

High

812988

CAZA2
F-actin-capping protein subunit alpha-2

1

7

High-throughput

0.618

High

821982

KC1A
Casein kinase I isoform alpha

1

3

Small-scale

0.618

High

841156

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.618

High

846919

SMCA4
Transcription activator BRG1

1

16

Small-scale

0.618

High

896867

ARP2
Actin-related protein 2

1

17

High-throughput

0.618

High

905825

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

Small-scale

0.618

High

906407

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

9

High-throughput

0.618

High

921519

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

6

High-throughput

0.618

High

932096

ACTC
Actin, alpha cardiac muscle 1

1

17

High-throughput

0.618

High

932958

KPCE
Protein kinase C epsilon type

1

8

Small-scale

0.618

High

932985

MK14
Mitogen-activated protein kinase 14

1

6

Small-scale

0.618

High

933012

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.618

High

933015

VRK3
Serine/threonine-protein kinase VRK3

1

8

High-throughput

0.618

High

933030

MY18A
Unconventional myosin-XVIIIa

1

17

High-throughput

0.618

High

933038

MARK4
MAP/microtubule affinity-regulating kinase 4

1

2

Small-scale

0.618

High

933050

PHAR1
Phosphatase and actin regulator 1

1

12

Small-scale

0.618

High

933067

KS6B2
Ribosomal protein S6 kinase beta-2

1

14

High-throughput

0.618

High

933074

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.618

High

932971

PPR1A
Protein phosphatase 1 regulatory subunit 1A

3

1

High-throughput

0.609

High

933029

NICA
Nicastrin

2

0

High-throughput

0.602

High

932965

DHX9
ATP-dependent RNA helicase A

1

3

Small-scale

0.586

High

346482

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

150057

TYB4Y
Thymosin beta-4, Y-chromosomal

1

2

Small-scale

0.579

High

211561

ACTN4
Alpha-actinin-4

1

11

Small-scale

0.575

High

932957

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

6

High-throughput

0.575

High

932974

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.575

High

932992

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

High-throughput

0.575

High

932995

Z324B
Zinc finger protein 324B

2

1

High-throughput

0.574

High

203910

HTRA2
Serine protease HTRA2, mitochondrial

1

2

Small-scale

0.569

High

624383

DNAS1
Deoxyribonuclease-1

1

0

Small-scale

0.546

High

66275

WASH1
WASH complex subunit 1

1

5

High-throughput

0.536

High

235496

VINEX
Vinexin

1

16

High-throughput

0.536

High

259933

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

1

High-throughput

0.536

High

273415

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.536

High

791474

HD
Huntingtin

1

3

High-throughput

0.536

High

827161

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.536

High

840665

DYN2
Dynamin-2

1

1

High-throughput

0.536

High

932959

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.536

High

932964

BTK
Tyrosine-protein kinase BTK

1

5

Small-scale

0.536

High

932973

CUL1
Cullin-1

1

9

High-throughput

0.536

High

932994

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.536

High

932999

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

7

High-throughput

0.536

High

933001

CRDL2
Chordin-like protein 2

1

1

High-throughput

0.536

High

933010

CHM1B
Charged multivesicular body protein 1b

1

3

High-throughput

0.536

High

933016

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

1

High-throughput

0.536

High

933051

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

2

High-throughput

0.536

High

933060

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.536

High

933033

MIB2
E3 ubiquitin-protein ligase MIB2

1

5

Small-scale

0.527

High

933071

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

5

Small-scale

0.527

High

933054

RN167
E3 ubiquitin-protein ligase RNF167

1

0

High-throughput

0.518

High

397901

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.515

High

933055

SYNCI
Syncoilin

1

2

High-throughput

0.515

High

882114

CLD20
Claudin-20

1

0

High-throughput

0.513

High

932970

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.513

High

933053

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

932984

HSPB2
Heat shock protein beta-2

1

5

High-throughput

0.508

High

932991

TNI3K
Serine/threonine-protein kinase TNNI3K

1

5

Small-scale

0.508

High

131235

BIN1
Myc box-dependent-interacting protein 1

1

6

Small-scale

0.501

High

337422

ABL1
Tyrosine-protein kinase ABL1

1

5

Small-scale

0.501

High

475605

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.501

High

496816

TAU
Microtubule-associated protein tau

1

16

Small-scale

0.501

High

742209

SYUA
Alpha-synuclein

1

4

Small-scale

0.501

High

880678

HDAC4
Histone deacetylase 4

1

6

Small-scale

0.501

High

932952

TCPB
T-complex protein 1 subunit beta

1

17

Small-scale

0.501

High

932986

FSCN1
Fascin

1

1

Small-scale

0.501

High

932989

AMOT
Angiomotin

1

20

Small-scale

0.501

High

933041

NEB2
Neurabin-2

1

13

Small-scale

0.501

High

933075

KLH20
Kelch-like protein 20

1

7

Small-scale

0.501

High

154550

ZN213
Zinc finger protein 213

1

1

High-throughput

0.489

High

932954

RT05
Small ribosomal subunit protein uS5m

1

2

High-throughput

0.489

High

933000

ANGL8
Angiopoietin-like protein 8

1

1

High-throughput

0.489

High

933011

TSN33
Tetraspanin-33

1

1

High-throughput

0.489

High

933018

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

14

High-throughput

0.489

High

933022

MIPT3
TRAF3-interacting protein 1

1

5

Small-scale

0.489

High

933025

DUS19
Dual specificity protein phosphatase 19

1

9

High-throughput

0.489

High

933079

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

13

High-throughput

0.489

High

427518

ANXA2
Annexin A2

1

4

Small-scale

0.481

High

933017

ABRA
Actin-binding Rho-activating protein

1

3

Small-scale

0.481

High

119327

LEG9
Galectin-9

1

6

High-throughput

0.479

High

227131

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

301752

TRI37
E3 ubiquitin-protein ligase TRIM37

1

19

High-throughput

0.479

High

338264

EGFR
Epidermal growth factor receptor

1

11

Small-scale

0.479

High

360636

SPTA1
Spectrin alpha chain, erythrocytic 1

1

20

Small-scale

0.479

High

376214

ANXA1
Annexin A1

1

4

Small-scale

0.479

High

384632

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

443455

VIME
Vimentin

1

1

Small-scale

0.479

High

499254

KIT
Mast/stem cell growth factor receptor Kit

1

3

Small-scale

0.479

High

501960

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

509624

UBL4A
Ubiquitin-like protein 4A

1

10

High-throughput

0.479

High

522893

SRC
Proto-oncogene tyrosine-protein kinase Src

1

5

Small-scale

0.479

High

540461

IL2RB
Interleukin-2 receptor subunit beta

1

4

Small-scale

0.479

High

547528

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

572339

LEG3
Galectin-3

1

6

Small-scale

0.479

High

580222

CADH2
Cadherin-2

1

1

Small-scale

0.479

High

590827

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

601881

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

12

High-throughput

0.479

High

610346

CBL
E3 ubiquitin-protein ligase CBL

1

8

Small-scale

0.479

High

666062

SHC1
SHC-transforming protein 1

1

10

High-throughput

0.479

High

683954

1433S
14-3-3 protein sigma

1

18

Small-scale

0.479

High

808500

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

832353

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

874811

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

915594

RHOB
Rho-related GTP-binding protein RhoB

1

8

High-throughput

0.479

High

917091

H4
Histone H4

1

2

High-throughput

0.479

High

932953

RED1
Double-stranded RNA-specific editase 1

1

11

High-throughput

0.479

High

932955

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

932960

TF65
Transcription factor p65

1

6

Small-scale

0.479

High

932963

UBE3A
Ubiquitin-protein ligase E3A

1

7

Small-scale

0.479

High

932966

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

932968

TFCP2
Alpha-globin transcription factor CP2

1

3

High-throughput

0.479

High

932972

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.479

High

932975

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

Small-scale

0.479

High

932979

CUL7
Cullin-7

1

1

High-throughput

0.479

High

932981

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

932982

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

932988

LARP7
La-related protein 7

1

11

High-throughput

0.479

High

933003

DNMBP
Dynamin-binding protein

1

9

Small-scale

0.479

High

933004

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

7

High-throughput

0.479

High

933020

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

933027

SSH1
Protein phosphatase Slingshot homolog 1

1

12

Small-scale

0.479

High

933031

KAT5
Histone acetyltransferase KAT5

1

9

Small-scale

0.479

High

933043

MELPH
Melanophilin

1

1

Small-scale

0.479

High

933048

TRI31
E3 ubiquitin-protein ligase TRIM31

1

11

High-throughput

0.479

High

933049

TRIM6
Tripartite motif-containing protein 6

1

6

Small-scale

0.479

High

933061

DMAP1
DNA methyltransferase 1-associated protein 1

1

5

Small-scale

0.479

High

933062

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

933069

TES
Testin

1

8

Small-scale

0.479

High

933070

LIMA1
LIM domain and actin-binding protein 1

1

13

High-throughput

0.479

High

933072

ERRFI
ERBB receptor feedback inhibitor 1

1

7

High-throughput

0.479

High

933076

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

5

Small-scale

0.479

High

933080

NCOA3
Nuclear receptor coactivator 3

1

1

Small-scale

0.479

High

563402

ZNF20
Zinc finger protein 20

1

2

High-throughput

0.470

High

933002

ASCL4
Achaete-scute homolog 4

1

4

High-throughput

0.470

High

933039

PNMA5
Paraneoplastic antigen-like protein 5

1

4

High-throughput

0.470

High

129736

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

932961

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

933014

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

933026

CTBL1
Beta-catenin-like protein 1

1

0

Small-scale

0.458

High

933028

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

933034

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

933035

CDCA5
Sororin

1

0

High-throughput

0.458

High

933040

XPO6
Exportin-6

1

0

Small-scale

0.458

High

933056

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

Small-scale

0.458

High

933013

NRAP
Nebulin-related-anchoring protein

1

16

Small-scale

0.457

High

933057

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

High-throughput

0.457

High

300998

ABLM3
Actin-binding LIM protein 3

1

7

Small-scale

0.445

High

532494

TCTP
Translationally-controlled tumor protein

1

2

Small-scale

0.445

High

821163

TCPE
T-complex protein 1 subunit epsilon

1

18

Small-scale

0.445

High

843152

TCPD
T-complex protein 1 subunit delta

1

15

Small-scale

0.445

High

932996

ABLM2
Actin-binding LIM protein 2

1

7

Small-scale

0.445

High

933047

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.439

High

303141

HEXI1
Protein HEXIM1

1

5

High-throughput

0.437

High

569569

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.437

High

932969

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

Small-scale

0.437

High

932980

MO4L2
Mortality factor 4-like protein 2

1

5

Small-scale

0.437

High

932993

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

932997

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.437

High

933006

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.437

High

933007

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

933008

MEPCE
7SK snRNA methylphosphate capping enzyme

1

5

High-throughput

0.437

High

933023

SSH3
Protein phosphatase Slingshot homolog 3

1

9

Small-scale

0.437

High

933036

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

8

High-throughput

0.437

High

933045

TX101
Testis-expressed protein 101

1

2

High-throughput

0.437

High

933046

HDAC8
Histone deacetylase 8

1

7

Small-scale

0.437

High

933059

RC3H2
Roquin-2

1

13

High-throughput

0.437

High

933063

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.437

High

933064

MRGBP
MRG/MORF4L-binding protein

1

3

Small-scale

0.437

High

933065

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

933068

MO4L1
Mortality factor 4-like protein 1

1

5

Small-scale

0.437

High

933077

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

932998

DUX4C
Double homeobox protein 4C

1

1

High-throughput

0.417

High

239924

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

933078

PCY1B
Choline-phosphate cytidylyltransferase B

1

2

Small-scale

0.407

High

63136

CCD69
Coiled-coil domain-containing protein 69

1

0

High-throughput

0.279

Low

270012

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.279

Low

932978

HLX
H2.0-like homeobox protein

1

0

High-throughput

0.279

Low

933009

MAEA
E3 ubiquitin-protein transferase MAEA

1

0

High-throughput

0.279

Low

933019

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.279

Low

933024

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.279

Low

933042

S39A3
Zinc transporter ZIP3

1

0

High-throughput

0.279

Low

933044

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

933052

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

933058

ELOV3
Very long chain fatty acid elongase 3

1

0

High-throughput

0.279

Low

932983

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.269

Low

932967

INCA1
Protein INCA1

1

0

High-throughput

0.268

Low

933005

LIAT1
Protein LIAT1

1

0

High-throughput

0.268

Low

245962

PFD1
Prefoldin subunit 1

1

0

Small-scale

0.261

Low

242065

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

932990

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.249

Low

933066

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.249

Low

563296

ZNF16
Zinc finger protein 16

1

0

Small-scale

0.238

Low

596534

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024