Protein: MAEA
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)

Gene: MAEA
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q7L5Y9

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1272728

RANB9
Ran-binding protein 9

9

20

Small-scale

0.972

High

1272749

RMD5A
E3 ubiquitin-protein transferase RMND5A

9

16

Small-scale

0.972

High

1272754

GID8
Glucose-induced degradation protein 8 homolog

5

17

Small-scale

0.937

High

1250488

RBP10
Ran-binding protein 10

3

17

High-throughput

0.866

High

1272717

RMD5B
E3 ubiquitin-protein transferase RMND5B

2

16

High-throughput

0.789

High

1272695

MAEA
E3 ubiquitin-protein transferase MAEA

2

17

Small-scale

0.768

High

1272698

ARMC8
Armadillo repeat-containing protein 8

5

8

Small-scale

0.720

High

561369

TDGF1
Protein Cripto

4

5

High-throughput

0.691

High

1272759

MKLN1
Muskelin

4

10

Small-scale

0.689

High

1272748

WDR26
WD repeat-containing protein 26

3

13

Small-scale

0.674

High

977131

YPEL5
Protein yippee-like 5

3

12

High-throughput

0.646

High

567900

PRG2
Bone marrow proteoglycan

4

11

High-throughput

0.630

High

1194784

GRPL2
GLIPR1-like protein 2

4

4

High-throughput

0.630

High

230644

PRIC3
Prickle planar cell polarity protein 3

2

5

High-throughput

0.628

High

562736

BMP1
Bone morphogenetic protein 1

2

6

High-throughput

0.628

High

1198302

TIGD5
Tigger transposable element-derived protein 5

2

3

High-throughput

0.628

High

1272714

RM38
Large ribosomal subunit protein mL38

2

1

High-throughput

0.628

High

1272722

JPH4
Junctophilin-4

2

3

High-throughput

0.628

High

1272699

GID4
Glucose-induced degradation protein 4 homolog

2

8

High-throughput

0.619

High

480379

MMP7
Matrilysin

2

6

High-throughput

0.611

High

1098568

GPS2
G protein pathway suppressor 2

2

3

High-throughput

0.611

High

1272718

AURKB
Aurora kinase B

2

3

High-throughput

0.611

High

814918

GDNF
Glial cell line-derived neurotrophic factor

3

3

High-throughput

0.609

High

1272737

RM04
Large ribosomal subunit protein uL4m

3

5

High-throughput

0.609

High

1272712

PIGT
GPI-anchor transamidase component PIGT

3

5

High-throughput

0.604

High

1272719

CC120
Coiled-coil domain-containing protein 120

3

6

High-throughput

0.604

High

1272761

PRG3
Proteoglycan 3

3

11

High-throughput

0.604

High

1272763

INSL6
Insulin-like peptide INSL6

3

5

High-throughput

0.604

High

1272735

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

377286

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

2

5

High-throughput

0.601

High

1047839

TLE1
Transducin-like enhancer protein 1

2

3

High-throughput

0.601

High

1104604

IKZF1
DNA-binding protein Ikaros

2

4

High-throughput

0.601

High

1272703

LYPD1
Ly6/PLAUR domain-containing protein 1

2

1

High-throughput

0.601

High

1272729

HPLN3
Hyaluronan and proteoglycan link protein 3

2

5

High-throughput

0.601

High

1272752

EMIL3
EMILIN-3

2

6

High-throughput

0.601

High

1272757

TCAL9
Transcription elongation factor A protein-like 9

2

4

High-throughput

0.601

High

970702

UBE2H
Ubiquitin-conjugating enzyme E2 H

2

15

High-throughput

0.595

High

1272720

SFRP2
Secreted frizzled-related protein 2

3

3

High-throughput

0.593

High

242110

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

1100051

TIF1B
Transcription intermediary factor 1-beta

2

5

Small-scale

0.584

High

1272740

PDGFD
Platelet-derived growth factor D

2

7

High-throughput

0.574

High

1272742

RM18
Large ribosomal subunit protein uL18m

2

5

High-throughput

0.549

High

169305

LECT2
Leukocyte cell-derived chemotaxin-2

1

4

High-throughput

0.536

High

216732

HTRA2
Serine protease HTRA2, mitochondrial

1

4

High-throughput

0.536

High

253444

CST8
Cystatin-8

1

3

High-throughput

0.536

High

270254

MTG16
Protein CBFA2T3

1

4

High-throughput

0.536

High

316670

LY6H
Lymphocyte antigen 6H

1

3

High-throughput

0.536

High

409586

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

4

High-throughput

0.536

High

425734

PERM
Myeloperoxidase

1

1

High-throughput

0.536

High

469806

CATG
Cathepsin G

1

2

High-throughput

0.536

High

506967

POTEI
POTE ankyrin domain family member I

1

2

High-throughput

0.536

High

555408

SKI
Ski oncogene

1

3

High-throughput

0.536

High

568567

TNNT1
Troponin T, slow skeletal muscle

1

2

High-throughput

0.536

High

608648

DDX5
Probable ATP-dependent RNA helicase DDX5

1

3

High-throughput

0.536

High

721721

GCH1
GTP cyclohydrolase 1

1

4

High-throughput

0.536

High

852107

TNNT3
Troponin T, fast skeletal muscle

1

2

High-throughput

0.536

High

852311

MMP13
Collagenase 3

1

6

High-throughput

0.536

High

872468

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

1048167

TLE4
Transducin-like enhancer protein 4

1

3

High-throughput

0.536

High

1163844

DUS6
Dual specificity protein phosphatase 6

1

4

High-throughput

0.536

High

1250843

CRDL2
Chordin-like protein 2

1

4

High-throughput

0.536

High

1272696

RHG22
Rho GTPase-activating protein 22

1

3

High-throughput

0.536

High

1272697

LCA5
Lebercilin

1

1

High-throughput

0.536

High

1272702

ELOA2
Elongin-A2

1

1

High-throughput

0.536

High

1272706

KCTD6
BTB/POZ domain-containing protein KCTD6

1

6

High-throughput

0.536

High

1272708

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

1

4

High-throughput

0.536

High

1272709

NEUR4
Sialidase-4

1

1

High-throughput

0.536

High

1272711

DDX17
Probable ATP-dependent RNA helicase DDX17

1

3

High-throughput

0.536

High

1272733

GDF15
Growth/differentiation factor 15

1

7

High-throughput

0.536

High

1272734

DDX50
ATP-dependent RNA helicase DDX50

1

9

High-throughput

0.536

High

1272739

UCK2
Uridine-cytidine kinase 2

1

1

High-throughput

0.536

High

1272751

SPON1
Spondin-1

1

6

High-throughput

0.536

High

1272756

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

6

High-throughput

0.536

High

954967

S10AA
Protein S100-A10

1

4

High-throughput

0.515

High

631812

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.513

High

664520

ALAT1
Alanine aminotransferase 1

1

0

High-throughput

0.513

High

933025

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.513

High

996489

ACTS
Actin, alpha skeletal muscle

1

0

High-throughput

0.513

High

1124170

IL27B
Interleukin-27 subunit beta

1

0

High-throughput

0.513

High

1272713

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

1272730

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.513

High

1272738

BACH2
Transcription regulator protein BACH2

1

0

High-throughput

0.513

High

1272753

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

891218

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.508

High

957113

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

High-throughput

0.501

High

1258769

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

6

High-throughput

0.501

High

63763

KRBA1
Protein KRBA1

1

1

High-throughput

0.489

High

155204

NCKP5
Nck-associated protein 5

1

2

High-throughput

0.489

High

278688

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

4

High-throughput

0.489

High

477339

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

4

High-throughput

0.489

High

652648

GNLY
Granulysin

1

5

High-throughput

0.489

High

945752

ISK7
Serine protease inhibitor Kazal-type 7

1

1

High-throughput

0.489

High

1013369

HTRA3
Serine protease HTRA3

1

4

High-throughput

0.489

High

1179804

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1206394

EFHC2
EF-hand domain-containing family member C2

1

4

High-throughput

0.489

High

1272710

COR2A
Coronin-2A

1

5

High-throughput

0.489

High

1272715

RT24
Small ribosomal subunit protein uS3m

1

3

High-throughput

0.489

High

1272725

IL17F
Interleukin-17F

1

2

High-throughput

0.489

High

1272741

WN10A
Protein Wnt-10a

1

5

High-throughput

0.489

High

1272758

MRM2
rRNA methyltransferase 2, mitochondrial

1

3

High-throughput

0.489

High

1272762

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

3

High-throughput

0.489

High

159720

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.479

High

248318

HBP1
HMG box-containing protein 1

1

11

High-throughput

0.479

High

279405

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

293917

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

315727

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

323453

TRI37
E3 ubiquitin-protein ligase TRIM37

1

4

High-throughput

0.479

High

474779

VIME
Vimentin

1

2

Small-scale

0.479

High

508192

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

762017

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.479

High

764862

CTNB1
Catenin beta-1

1

2

Small-scale

0.479

High

955950

RAB8A
Ras-related protein Rab-8A

1

5

High-throughput

0.479

High

990408

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

1113513

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1121258

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

1152008

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

11

High-throughput

0.479

High

1163735

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

11

High-throughput

0.479

High

1254381

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1272701

KIBRA
Protein KIBRA

1

10

Small-scale

0.479

High

1272721

WNK4
Serine/threonine-protein kinase WNK4

1

6

Small-scale

0.479

High

1272731

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1272744

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

1272745

WNK1
Serine/threonine-protein kinase WNK1

1

6

Small-scale

0.479

High

1272746

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

1272750

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

223145

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

272283

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

331084

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

675069

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

1272704

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

1272724

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1056815

FMR1
Fragile X messenger ribonucleoprotein 1

1

4

High-throughput

0.457

High

181133

AXIN1
Axin-1

1

3

Small-scale

0.445

High

639145

SYT1
Synaptotagmin-1

1

6

High-throughput

0.445

High

871963

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

4

High-throughput

0.445

High

1181478

EMAL3
Echinoderm microtubule-associated protein-like 3

1

4

High-throughput

0.445

High

1272705

SYT2
Synaptotagmin-2

1

6

High-throughput

0.445

High

1272707

CAMKV
CaM kinase-like vesicle-associated protein

1

2

High-throughput

0.445

High

1272736

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

1

High-throughput

0.445

High

1272743

OSBL5
Oxysterol-binding protein-related protein 5

1

1

High-throughput

0.445

High

1272760

COR2B
Coronin-2B

1

4

High-throughput

0.445

High

139069

LAD1
Ladinin-1

1

2

Small-scale

0.437

High

1243900

SG11A
Sperm-associated antigen 11A

1

1

High-throughput

0.437

High

1186404

ASTRB
Protein Aster-B

1

0

High-throughput

0.426

High

615184

PACA
Pituitary adenylate cyclase-activating polypeptide

1

4

High-throughput

0.407

High

1064635

SG11B
Sperm-associated antigen 11B

1

1

High-throughput

0.407

High

1272727

PEO1
Twinkle mtDNA helicase

1

3

High-throughput

0.407

High

1249658

CF015
Uncharacterized protein C6orf15

1

0

High-throughput

0.279

Low

1272716

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

1272723

CALR3
Calreticulin-3

1

0

High-throughput

0.279

Low

1272726

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1272747

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

1272755

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

1272732

MYOC
Myocilin

1

0

Small-scale

0.251

Low

1272700

NNRD
ATP-dependent

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025