Protein: STK39
STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)

Gene: STK39
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9UEW8

Gene Ontology (top 5):
GO:0002021 - response to dietary excess
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

845547

PI2R
Prostacyclin receptor

2

0

High-throughput

0.770

High

1251972

LMTK1
Serine/threonine-protein kinase LMTK1

2

20

Small-scale

0.757

High

401651

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

14

High-throughput

0.737

High

436752

KPCB
Protein kinase C beta type

2

15

High-throughput

0.737

High

531170

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

High-throughput

0.737

High

988795

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

High-throughput

0.737

High

1097170

MK07
Mitogen-activated protein kinase 7

2

20

High-throughput

0.737

High

1459052

CAB39
Calcium-binding protein 39

1

6

Small-scale

0.724

High

351808

LGI1
Leucine-rich glioma-inactivated protein 1

1

6

High-throughput

0.691

High

841592

I12R1
Interleukin-12 receptor subunit beta-1

1

2

High-throughput

0.691

High

962598

RHOA
Transforming protein RhoA

1

20

High-throughput

0.691

High

1418963

WNK3
Serine/threonine-protein kinase WNK3

1

19

High-throughput

0.691

High

1381823

TR19L
Tumor necrosis factor receptor superfamily member 19L

4

5

High-throughput

0.691

High

1459053

T22D4
TSC22 domain family protein 4

3

2

High-throughput

0.667

High

1459050

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

17

Small-scale

0.647

High

1459051

S12A6
Solute carrier family 12 member 6

3

12

Small-scale

0.633

High

562465

LAMP2
Lysosome-associated membrane glycoprotein 2

2

7

High-throughput

0.628

High

1308011

RELL1
RELT-like protein 1

2

5

High-throughput

0.628

High

1334456

RELL2
RELT-like protein 2

2

5

High-throughput

0.628

High

1394708

WNK4
Serine/threonine-protein kinase WNK4

1

19

Small-scale

0.621

High

74634

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.618

High

243201

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

719274

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.618

High

831589

CCNF
Cyclin-F

1

2

High-throughput

0.618

High

920333

PLK1
Serine/threonine-protein kinase PLK1

1

16

Small-scale

0.618

High

1146488

KS6A2
Ribosomal protein S6 kinase alpha-2

1

18

High-throughput

0.618

High

1157981

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.618

High

1158197

MK14
Mitogen-activated protein kinase 14

1

14

Small-scale

0.618

High

1255953

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1434145

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

933495

S12A2
Solute carrier family 12 member 2

2

9

Small-scale

0.576

High

231649

PRKY
Putative serine/threonine-protein kinase PRKY

1

19

High-throughput

0.575

High

466984

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.575

High

1366293

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.575

High

1327809

SH2D3
SH2 domain-containing protein 3C

2

9

High-throughput

0.571

High

543442

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

3

High-throughput

0.553

High

277964

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

253459

CST8
Cystatin-8

1

1

High-throughput

0.536

High

1053080

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.536

High

1270863

SV2A
Synaptic vesicle glycoprotein 2A

1

3

High-throughput

0.536

High

1293688

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.536

High

1310497

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.536

High

1383883

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1402731

TCPQM
T-complex protein 1 subunit theta-like 2

1

10

High-throughput

0.536

High

1429306

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.536

High

1434475

BAFL
Barrier-to-autointegration factor-like protein

1

1

High-throughput

0.536

High

260810

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.513

High

342687

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.513

High

388325

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

1292421

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

1458367

RBX2
RING-box protein 2

1

0

High-throughput

0.513

High

1458436

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

388094

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

1415178

ASHWN
Ashwin

1

0

High-throughput

0.493

High

1326752

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

1

High-throughput

0.489

High

1340120

ATLA2
Atlastin-2

1

1

High-throughput

0.489

High

1430767

CSTL1
Cystatin-like 1

1

1

High-throughput

0.489

High

1432125

KLK15
Kallikrein-15

1

6

High-throughput

0.489

High

1438717

CRLF2
Cytokine receptor-like factor 2

1

3

High-throughput

0.489

High

442511

GELS
Gelsolin

1

2

Small-scale

0.481

High

1365258

HS105
Heat shock protein 105 kDa

1

8

Small-scale

0.481

High

1438527

OTOF
Otoferlin

1

4

Small-scale

0.481

High

538058

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

589948

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

696771

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

714491

PML
Protein PML

1

6

High-throughput

0.479

High

765086

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

769423

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

888371

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

1067799

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1114558

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1161424

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

High-throughput

0.479

High

1445746

WDR6
tRNA

1

13

Small-scale

0.479

High

437817

HEPS
Serine protease hepsin

1

2

High-throughput

0.445

High

1115506

S12A1
Solute carrier family 12 member 1

1

10

High-throughput

0.445

High

1197902

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.445

High

1239326

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

273290

T22D2
TSC22 domain family protein 2

1

2

Small-scale

0.439

High

106794

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

342350

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.437

High

445610

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.426

High

1432303

SO5A1
Solute carrier organic anion transporter family member 5A1

1

0

High-throughput

0.426

High

62171

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

0

High-throughput

0.328

High

1362532

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

0

High-throughput

0.328

High

1449121

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

High-throughput

0.328

High

914366

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1181033

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

1400994

ARX
Homeobox protein ARX

1

0

High-throughput

0.279

Low

584691

MCP
Membrane cofactor protein

1

0

Small-scale

0.269

Low

522306

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

1135512

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025