Protein: RRN3
RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)

Gene: RRN3
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q9NYV6

Gene Ontology (top 5):
GO:0001042 - RNA polymerase I core binding
GO:0001164 - RNA polymerase I core promoter sequence-specific DNA binding
GO:0001181 - RNA polymerase I general transcription initiation factor activity
GO:0001701 - in utero embryonic development
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

340047

RPA1
DNA-directed RNA polymerase I subunit RPA1

4

2

Small-scale

0.881

High

1185171

RPA43
DNA-directed RNA polymerase I subunit RPA43

3

1

High-throughput

0.861

High

1428654

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

1

Small-scale

0.811

High

1437318

RPA2
DNA-directed RNA polymerase I subunit RPA2

2

2

Small-scale

0.789

High

1200526

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

1

Small-scale

0.724

High

959079

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.656

High

180418

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.628

High

1339377

I17RD
Interleukin-17 receptor D

2

0

High-throughput

0.585

High

191134

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.513

High

983724

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

1434630

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.513

High

1452834

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.513

High

506999

POTEI
POTE ankyrin domain family member I

1

1

High-throughput

0.489

High

667017

CCNE1
G1/S-specific cyclin-E1

1

0

Small-scale

0.480

High

668048

CDK2
Cyclin-dependent kinase 2

1

0

Small-scale

0.480

High

991112

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

Small-scale

0.480

High

1150320

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

Small-scale

0.480

High

1150354

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

Small-scale

0.480

High

1452836

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

Small-scale

0.480

High

123855

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

604752

UBF1
Nucleolar transcription factor 1

1

0

Small-scale

0.458

High

628850

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

1005177

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1029398

SET
Protein SET

1

0

Small-scale

0.458

High

1281627

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1452835

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.458

High

516809

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

1249777

TM108
Transmembrane protein 108

2

0

High-throughput

0.328

High

1452837

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

346424

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

996551

ACTS
Actin, alpha skeletal muscle

1

0

Small-scale

0.249

Low

1255847

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025