Protein: EIF3L
Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)

Gene: EIF3L
Organism: Homo sapiens
Interactions: 235
UniProt ID: Q9Y262

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458622

EIF3K
Eukaryotic translation initiation factor 3 subunit K

12

2

Small-scale

0.984

High

949465

EIF3E
Eukaryotic translation initiation factor 3 subunit E

13

1

Small-scale

0.980

High

1271693

EIF3M
Eukaryotic translation initiation factor 3 subunit M

7

1

Small-scale

0.964

High

1121923

EIF3A
Eukaryotic translation initiation factor 3 subunit A

6

1

Small-scale

0.947

High

131536

EIF3F
Eukaryotic translation initiation factor 3 subunit F

6

5

Small-scale

0.944

High

1405786

EIF3C
Eukaryotic translation initiation factor 3 subunit C

4

2

Small-scale

0.899

High

81743

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

3

2

High-throughput

0.861

High

188066

EIF3H
Eukaryotic translation initiation factor 3 subunit H

11

5

Small-scale

0.755

High

187823

EIF3D
Eukaryotic translation initiation factor 3 subunit D

7

1

Small-scale

0.747

High

939467

EIF3B
Eukaryotic translation initiation factor 3 subunit B

5

2

Small-scale

0.720

High

295259

EIF3G
Eukaryotic translation initiation factor 3 subunit G

5

2

High-throughput

0.718

High

1102932

EIF3I
Eukaryotic translation initiation factor 3 subunit I

5

1

High-throughput

0.718

High

343111

HERC2
E3 ubiquitin-protein ligase HERC2

4

2

Small-scale

0.683

High

625712

CSK22
Casein kinase II subunit alpha'

3

2

High-throughput

0.667

High

1238509

ZN746
Zinc finger protein 746

4

0

High-throughput

0.661

High

128342

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.656

High

1124320

IF4A2
Eukaryotic initiation factor 4A-II

3

1

High-throughput

0.650

High

1206580

PRC2B
Protein PRRC2B

2

1

High-throughput

0.628

High

998119

CSK21
Casein kinase II subunit alpha

2

2

High-throughput

0.611

High

1101104

G3BP1
Ras GTPase-activating protein-binding protein 1

2

1

High-throughput

0.611

High

243317

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

1047145

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

2

3

Small-scale

0.584

High

1227728

A16L1
Autophagy-related protein 16-1

2

3

High-throughput

0.584

High

831668

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

397252

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

631570

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

935311

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.547

High

244290

NUAK1
NUAK family SNF1-like kinase 1

1

1

High-throughput

0.536

High

581603

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

766026

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

832151

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.536

High

984336

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

993032

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.536

High

1006959

KC1G2
Casein kinase I isoform gamma-2

1

2

High-throughput

0.536

High

1112804

CUL1
Cullin-1

1

1

High-throughput

0.536

High

1396068

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

1413418

RBM42
RNA-binding protein 42

1

3

High-throughput

0.536

High

1415649

RIOK2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.536

High

1462232

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.536

High

530608

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.528

High

167421

KLF11
Krueppel-like factor 11

1

2

High-throughput

0.515

High

227185

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

0

High-throughput

0.513

High

271585

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

303664

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

407144

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

445621

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

447593

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

479493

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

564579

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

635015

MAK
Serine/threonine-protein kinase MAK

1

0

High-throughput

0.513

High

692165

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.513

High

694075

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

859509

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

867527

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

884278

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

886619

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

897104

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

908230

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

0

High-throughput

0.513

High

933367

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

951528

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

970177

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1060815

ACK1
Activated CDC42 kinase 1

1

0

High-throughput

0.513

High

1126583

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1136085

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

1161764

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

1313608

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1337726

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1360533

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1396427

PHAR3
Phosphatase and actin regulator 3

1

0

High-throughput

0.513

High

1405158

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

1417990

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.513

High

1437083

AGO3
Protein argonaute-3

1

0

High-throughput

0.513

High

1446152

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

1458659

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.513

High

1459782

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1490506

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

375024

RASH
GTPase HRas

1

1

Small-scale

0.501

High

1042944

ERCC6
DNA excision repair protein ERCC-6

1

2

High-throughput

0.501

High

339901

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.500

High

254659

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.493

High

1281642

SLN11
Schlafen family member 11

1

0

Small-scale

0.493

High

1278521

TT21B
Tetratricopeptide repeat protein 21B

1

1

High-throughput

0.489

High

833444

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.486

High

1153948

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.486

High

1429824

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.486

High

1452836

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.480

High

295372

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

Small-scale

0.479

High

132387

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

138342

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

158004

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

173573

XPO1
Exportin-1

1

3

High-throughput

0.479

High

216138

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

3

High-throughput

0.479

High

260628

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

288544

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.479

High

302672

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

316175

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

350184

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

376110

RASK
GTPase KRas

1

1

High-throughput

0.479

High

427960

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.479

High

636168

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

684440

DDX6
Probable ATP-dependent RNA helicase DDX6

1

1

High-throughput

0.479

High

714528

PML
Protein PML

1

1

High-throughput

0.479

High

862566

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

907630

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

1040946

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

1051339

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.479

High

1088623

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1098388

ERCC8
DNA excision repair protein ERCC-8

1

1

Small-scale

0.479

High

1100552

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1109579

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1115154

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1131156

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

1133056

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1138179

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1152396

ZN174
Zinc finger protein 174

1

1

High-throughput

0.479

High

1155917

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1194462

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1280612

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1337853

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

1367620

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1368218

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1404845

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1411763

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1417106

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

1437888

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1458553

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

1461912

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

1462104

UBQL1
Ubiquilin-1

1

1

High-throughput

0.479

High

1462745

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

1490508

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

791851

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

125667

LEG9
Galectin-9

1

0

High-throughput

0.458

High

283574

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.458

High

325170

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

337050

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

346519

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

373530

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

414875

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

521051

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.458

High

565491

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

590061

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

591894

H2AX
Histone H2AX

1

0

Small-scale

0.458

High

660757

IF4B
Eukaryotic translation initiation factor 4B

1

0

Small-scale

0.458

High

662521

GATA2
Endothelial transcription factor GATA-2

1

0

High-throughput

0.458

High

696895

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

731712

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

769544

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799590

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

837910

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

872904

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

879629

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

888401

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

948964

CD81
CD81 antigen

1

0

High-throughput

0.458

High

954314

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

957557

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

965340

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

971305

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1005255

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1036002

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1067854

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1083338

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.458

High

1092276

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1107344

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1127254

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1138769

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1141058

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1205506

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

1216593

EFCB6
EF-hand calcium-binding domain-containing protein 6

1

0

High-throughput

0.458

High

1220898

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1229773

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1247936

ANR12
Ankyrin repeat domain-containing protein 12

1

0

High-throughput

0.458

High

1288609

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1313543

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1323591

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1335077

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1336607

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.458

High

1364708

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1380609

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.458

High

1403377

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1407958

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1418530

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1429890

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1431566

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1431675

GAN
Gigaxonin

1

0

High-throughput

0.458

High

1438556

LFG4
Protein lifeguard 4

1

0

High-throughput

0.458

High

1438950

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

1447024

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1447457

ANLN
Anillin

1

0

High-throughput

0.458

High

1448125

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1448249

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1459351

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1462334

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

1416961

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

1209806

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

896939

DYN2
Dynamin-2

1

0

High-throughput

0.438

High

1395044

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

1448576

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1109593

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1434260

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1462693

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.437

High

62618

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

133595

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.426

High

430525

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

567525

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

1111372

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1203298

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1292309

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1330804

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.426

High

1380370

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

0

High-throughput

0.426

High

1405542

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.426

High

1239759

PPR18
Phostensin

2

0

High-throughput

0.316

High

619957

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.298

High

176901

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.279

Low

1013359

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1341349

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

1346669

VANG1
Vang-like protein 1

1

0

High-throughput

0.279

Low

1490507

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.279

Low

239254

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.249

Low

294543

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

377235

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

389572

FINC
Fibronectin

1

0

High-throughput

0.249

Low

412831

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1135862

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1194739

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

1249338

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256143

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276986

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1324114

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1372482

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.249

Low

1436481

AKTIP
AKT-interacting protein

1

0

Small-scale

0.249

Low

87560

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

1214222

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1396590

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low

1428270

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low

1436767

GHC1
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025