Protein: GCH1
GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)

Gene: GCH1
Organism: Homo sapiens
Interactions: 67
UniProt ID: P30793

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003934 - GTP cyclohydrolase I activity
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

721700

GCH1
GTP cyclohydrolase 1

3

7

Small-scale

0.829

High

716482

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

1

1

Small-scale

0.656

High

721730

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

1

High-throughput

0.628

High

164535

TNPO2
Transportin-2

2

1

High-throughput

0.606

High

721750

TNPO3
Transportin-3

2

1

High-throughput

0.606

High

721707

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.561

High

721720

RBP10
Ran-binding protein 10

1

2

High-throughput

0.536

High

721721

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.536

High

721722

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.536

High

721733

RANB9
Ran-binding protein 9

1

2

High-throughput

0.536

High

721739

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

3

High-throughput

0.536

High

721744

GID8
Glucose-induced degradation protein 8 homolog

1

4

High-throughput

0.536

High

336871

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.529

High

721716

GIT2
ARF GTPase-activating protein GIT2

1

0

High-throughput

0.518

High

721704

MK12
Mitogen-activated protein kinase 12

1

1

Small-scale

0.515

High

721705

MK10
Mitogen-activated protein kinase 10

1

1

Small-scale

0.515

High

65901

RHG42
Rho GTPase-activating protein 42

1

0

High-throughput

0.513

High

623997

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

663385

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.513

High

721711

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.513

High

721712

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.513

High

721715

SQSTM
Sequestosome-1

1

0

High-throughput

0.513

High

721717

ELOB
Elongin-B

1

0

High-throughput

0.513

High

721718

SIX1
Homeobox protein SIX1

1

0

High-throughput

0.513

High

721724

DEN6A
Protein DENND6A

1

0

High-throughput

0.513

High

721728

DAAF4
Dynein axonemal assembly factor 4

1

0

High-throughput

0.513

High

721731

MOCOS
Molybdenum cofactor sulfurase

1

0

High-throughput

0.513

High

721734

OSBL9
Oxysterol-binding protein-related protein 9

1

0

High-throughput

0.513

High

721735

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.513

High

721738

WDR26
WD repeat-containing protein 26

1

0

High-throughput

0.513

High

721741

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

721742

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.513

High

721743

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.513

High

721746

DCDC2
Doublecortin domain-containing protein 2

1

0

High-throughput

0.513

High

721751

SNX9
Sorting nexin-9

1

0

High-throughput

0.513

High

673803

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.493

High

721709

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.493

High

536587

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.486

High

721710

SP3
Transcription factor Sp3

1

0

Small-scale

0.486

High

721713

RLF
Zinc finger protein Rlf

1

0

Small-scale

0.486

High

721719

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

721732

CNRP1
CB1 cannabinoid receptor-interacting protein 1

1

0

Small-scale

0.486

High

721736

SH3G2
Endophilin-A1

1

0

High-throughput

0.486

High

721748

RAB26
Ras-related protein Rab-26

1

0

Small-scale

0.486

High

568766

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

Small-scale

0.479

High

721701

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

Small-scale

0.479

High

721702

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

1

Small-scale

0.479

High

721723

GID4
Glucose-induced degradation protein 4 homolog

1

1

High-throughput

0.479

High

721740

KC1G1
Casein kinase I isoform gamma-1

1

1

Small-scale

0.479

High

721747

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

1

Small-scale

0.479

High

290870

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.458

High

721703

RGS19
Regulator of G-protein signaling 19

1

0

Small-scale

0.458

High

721706

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

721708

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.458

High

721725

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

0

Small-scale

0.458

High

721726

CALL6
Calmodulin-like protein 6

1

0

Small-scale

0.458

High

721745

CALL5
Calmodulin-like protein 5

1

0

Small-scale

0.458

High

721749

RP3A
Rabphilin-3A

1

0

Small-scale

0.458

High

721729

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

High-throughput

0.445

High

721714

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

1

Small-scale

0.437

High

721727

SCTM1
Secreted and transmembrane protein 1

1

1

High-throughput

0.437

High

117049

J3KSN0
Protein K-12

1

1

High-throughput

0.407

High

117297

K7ENE2
GID complex subunit 4 homolog

1

1

High-throughput

0.407

High

137040

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

0

High-throughput

0.279

Low

721737

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

High-throughput

0.279

Low

420770

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025