Protein: PUSL1
tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1)

Gene: PUSL1
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q8N0Z8

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005739 - mitochondrion
GO:0009982 - pseudouridine synthase activity
GO:0031119 - tRNA pseudouridine synthesis
GO:0043231 - intracellular membrane-bounded organelle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

552634

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

3

2

High-throughput

0.667

High

532760

CH60
60 kDa heat shock protein, mitochondrial

3

1

High-throughput

0.662

High

635343

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

3

2

High-throughput

0.662

High

1110499

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

3

2

High-throughput

0.604

High

1322499

ISOC2
Isochorismatase domain-containing protein 2

2

0

High-throughput

0.602

High

1016514

SRSF3
Serine/arginine-rich splicing factor 3

2

0

High-throughput

0.576

High

1322500

KCD12
BTB/POZ domain-containing protein KCTD12

2

0

High-throughput

0.576

High

1322507

CAD19
Cadherin-19

2

1

High-throughput

0.558

High

1123346

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1322513

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

396486

ESR1
Estrogen receptor

2

2

High-throughput

0.521

High

1037553

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1148727

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.513

High

1322508

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

258980

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.489

High

1110376

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

High-throughput

0.489

High

1214073

KIF24
Kinesin-like protein KIF24

1

1

High-throughput

0.489

High

1216674

CROCC
Rootletin

1

1

High-throughput

0.489

High

1322505

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

422556

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1322514

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

292169

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

1322498

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

324978

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

653430

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

1235717

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

1

High-throughput

0.445

High

695918

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768626

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1292784

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.437

High

1322501

Q96KY9
CDH19 protein

1

1

High-throughput

0.407

High

1322509

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

239126

ZNRD2
Protein ZNRD2

3

0

High-throughput

0.345

High

716488

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.328

High

1151013

PCH2
Pachytene checkpoint protein 2 homolog

2

0

High-throughput

0.328

High

1180401

KLH40
Kelch-like protein 40

2

0

High-throughput

0.328

High

1322516

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

2

0

High-throughput

0.318

High

190430

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

380315

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.279

Low

391343

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

549638

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

1014861

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

0

High-throughput

0.279

Low

1054615

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.279

Low

1091050

FOXF1
Forkhead box protein F1

1

0

High-throughput

0.279

Low

1199917

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

1203719

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1281416

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

1307252

TF2LX
Homeobox protein TGIF2LX

1

0

High-throughput

0.279

Low

1315959

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1322497

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

0

High-throughput

0.279

Low

1322502

ZNF48
Zinc finger protein 48

1

0

High-throughput

0.279

Low

1322503

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

1322504

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

0

High-throughput

0.279

Low

1322506

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.279

Low

1322511

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.279

Low

1322512

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

1322515

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

1322517

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

138211

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.249

Low

1322510

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.249

Low

58866

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

714263

PML
Protein PML

1

0

High-throughput

0.232

Low

844827

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025