Protein: XRCC3
DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)

Gene: XRCC3
Organism: Homo sapiens
Interactions: 182
UniProt ID: O43542

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219056

RA51C
DNA repair protein RAD51 homolog 3

18

17

Small-scale

0.990

High

219948

RAD51
DNA repair protein RAD51 homolog 1

5

18

Small-scale

0.920

High

219938

BRCA2
Breast cancer type 2 susceptibility protein

5

10

Small-scale

0.912

High

220025

TOM22
Mitochondrial import receptor subunit TOM22 homolog

3

1

High-throughput

0.675

High

185128

FANCG
Fanconi anemia group G protein

3

0

Small-scale

0.633

High

219914

LAMP2
Lysosome-associated membrane glycoprotein 2

2

1

High-throughput

0.628

High

220039

LAMP3
Lysosome-associated membrane glycoprotein 3

2

1

High-throughput

0.628

High

219988

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

219969

SWAP1
ATPase SWSAP1

1

4

Small-scale

0.578

High

220031

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

3

High-throughput

0.574

High

219975

PALB2
Partner and localizer of BRCA2

1

3

Small-scale

0.568

High

219928

SPB5
Serpin B5

1

1

High-throughput

0.541

High

219956

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.541

High

219968

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

6

High-throughput

0.541

High

219989

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.541

High

219999

LRAT2
Protein LRATD2

1

1

High-throughput

0.541

High

220032

HOP2
Homologous-pairing protein 2 homolog

1

3

High-throughput

0.541

High

219887

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

2

High-throughput

0.536

High

219890

IF2P
Eukaryotic translation initiation factor 5B

1

3

High-throughput

0.536

High

219891

DNJA2
DnaJ homolog subfamily A member 2

1

4

High-throughput

0.536

High

219895

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.536

High

219899

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.536

High

219901

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.536

High

219905

S100B
Protein S100-B

1

2

High-throughput

0.536

High

219906

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.536

High

219908

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.536

High

219909

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.536

High

219911

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.536

High

219912

PYC
Pyruvate carboxylase, mitochondrial

1

3

High-throughput

0.536

High

219913

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.536

High

219915

ENPL
Endoplasmin

1

4

High-throughput

0.536

High

219916

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

219917

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.536

High

219919

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

1

High-throughput

0.536

High

219921

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

219923

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

4

High-throughput

0.536

High

219924

DNJA1
DnaJ homolog subfamily A member 1

1

4

High-throughput

0.536

High

219929

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.536

High

219933

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.536

High

219935

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.536

High

219937

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.536

High

219940

RBM5
RNA-binding protein 5

1

2

High-throughput

0.536

High

219941

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

219942

PMS2
Mismatch repair endonuclease PMS2

1

3

High-throughput

0.536

High

219947

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.536

High

219949

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.536

High

219953

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.536

High

219955

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.536

High

219957

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.536

High

219967

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

219971

HDGR2
Hepatoma-derived growth factor-related protein 2

1

2

High-throughput

0.536

High

219977

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

1

High-throughput

0.536

High

219978

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

High-throughput

0.536

High

219981

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

2

High-throughput

0.536

High

219990

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.536

High

219991

TNPO1
Transportin-1

1

1

High-throughput

0.536

High

219997

HOOK2
Protein Hook homolog 2

1

5

High-throughput

0.536

High

220000

IPO9
Importin-9

1

2

High-throughput

0.536

High

220005

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

2

High-throughput

0.536

High

220007

METH
Methionine synthase

1

1

High-throughput

0.536

High

220011

SFXN3
Sideroflexin-3

1

1

High-throughput

0.536

High

220013

TB182
182 kDa tankyrase-1-binding protein

1

2

High-throughput

0.536

High

220014

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.536

High

220016

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

High-throughput

0.536

High

220017

UN45A
Protein unc-45 homolog A

1

1

High-throughput

0.536

High

220022

SFXN1
Sideroflexin-1

1

1

High-throughput

0.536

High

220034

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.536

High

220036

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

High-throughput

0.536

High

220045

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.536

High

220049

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

1

High-throughput

0.536

High

219963

ZSWM7
Zinc finger SWIM domain-containing protein 7

1

1

Small-scale

0.527

High

219902

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.518

High

219961

ZNHI3
Zinc finger HIT domain-containing protein 3

1

0

High-throughput

0.518

High

219966

GREB1
Protein GREB1

1

0

High-throughput

0.518

High

220020

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.518

High

124155

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.513

High

131241

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.513

High

158059

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

168943

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.513

High

211693

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

219888

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.513

High

219892

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

219893

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.513

High

219896

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.513

High

219900

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.513

High

219907

DPOLB
DNA polymerase beta

1

0

High-throughput

0.513

High

219920

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

219925

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.513

High

219930

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

219931

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.513

High

219936

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.513

High

219939

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

219943

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.513

High

219952

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.513

High

219960

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

219964

INF2
Inverted formin-2

1

0

High-throughput

0.513

High

219972

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.513

High

219980

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.513

High

219984

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.513

High

219985

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.513

High

219986

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.513

High

219987

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.513

High

219994

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.513

High

219998

SPF45
Splicing factor 45

1

0

High-throughput

0.513

High

220001

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.513

High

220003

ERBIN
Erbin

1

0

High-throughput

0.513

High

220004

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

220006

PHB2
Prohibitin-2

1

0

High-throughput

0.513

High

220010

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.513

High

220015

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.513

High

220021

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

220023

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

220024

JPH1
Junctophilin-1

1

0

High-throughput

0.513

High

220028

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

220029

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.513

High

220042

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.513

High

220043

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.513

High

220044

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.513

High

219904

TFF1
Trefoil factor 1

1

1

High-throughput

0.494

High

219974

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

2

High-throughput

0.494

High

219886

CALU
Calumenin

1

2

High-throughput

0.489

High

219918

TRYB2
Tryptase beta-2

1

2

High-throughput

0.489

High

219959

RCN1
Reticulocalbin-1

1

2

High-throughput

0.489

High

219962

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.489

High

219973

KTN1
Kinectin

1

2

High-throughput

0.489

High

219995

RCN3
Reticulocalbin-3

1

2

High-throughput

0.489

High

220008

RNF5
E3 ubiquitin-protein ligase RNF5

1

3

High-throughput

0.489

High

220046

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

220047

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

161765

RIOK3
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.479

High

172291

XPO1
Exportin-1

1

5

High-throughput

0.479

High

187423

FANCA
Fanconi anemia group A protein

1

2

Small-scale

0.479

High

219898

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

219922

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

219945

RBM10
RNA-binding protein 10

1

2

High-throughput

0.479

High

219954

NCOA4
Nuclear receptor coactivator 4

1

1

High-throughput

0.479

High

219979

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

220019

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

220035

XPO7
Exportin-7

1

4

High-throughput

0.479

High

219903

MBD3
Methyl-CpG-binding domain protein 3

1

0

High-throughput

0.458

High

219965

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

76667

B4E1Q4
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.445

High

107360

F8W038
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.445

High

107399

F8W7C6
Ribosomal protein L10

1

1

High-throughput

0.445

High

219950

SLAF1
Signaling lymphocytic activation molecule

1

1

High-throughput

0.437

High

220009

DERL1
Derlin-1

1

1

High-throughput

0.437

High

220038

SSRG
Translocon-associated protein subunit gamma

1

1

High-throughput

0.437

High

220041

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.437

High

219889

NEMF
Ribosome quality control complex subunit NEMF

1

0

High-throughput

0.426

High

220027

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.426

High

76656

B4E1G1
Derlin

1

1

High-throughput

0.407

High

91617

C9JA28
Translocon-associated protein subunit gamma

1

1

High-throughput

0.407

High

219932

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.407

High

219996

Q96E88
NCOA4 protein

1

1

High-throughput

0.407

High

220012

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

220026

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.407

High

220040

S22AD
Solute carrier family 22 member 13

1

2

High-throughput

0.407

High

154779

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

219946

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.347

High

219958

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

219910

GROA
Growth-regulated alpha protein

1

0

High-throughput

0.282

High

220002

SG3A1
Secretoglobin family 3A member 1

1

0

High-throughput

0.282

High

220033

MRC2
C-type mannose receptor 2

1

0

High-throughput

0.282

High

220037

OSGI1
Oxidative stress-induced growth inhibitor 1

1

0

High-throughput

0.282

High

165487

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.279

Low

190285

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

219894

ERLN1
Erlin-1

1

0

High-throughput

0.279

Low

219897

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

219926

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.279

Low

219927

APJ
Apelin receptor

1

0

High-throughput

0.279

Low

219934

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

219944

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

219951

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

219970

INSY2
Inhibitory synaptic factor 2A

1

0

High-throughput

0.279

Low

219982

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

219992

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.279

Low

219993

SO4A1
Solute carrier organic anion transporter family member 4A1

1

0

High-throughput

0.279

Low

220030

MYOF
Myoferlin

1

0

High-throughput

0.279

Low

220048

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.279

Low

220018

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

219976

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.232

Low

219983

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025