Protein: PIGR
Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]

Gene: PIGR
Organism: Homo sapiens
Interactions: 140
UniProt ID: P01833

Gene Ontology (top 5):
GO:0001580 - detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001790 - polymeric immunoglobulin binding
GO:0001792 - polymeric immunoglobulin receptor activity
GO:0002415 - immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0004888 - transmembrane signaling receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

379032

HVCN1
Voltage-gated hydrogen channel 1

2

1

High-throughput

0.789

High

379001

HBM
Hemoglobin subunit mu

2

1

High-throughput

0.726

High

379044

DDX31
ATP-dependent DNA helicase DDX31

2

1

High-throughput

0.726

High

210645

KLK10
Kallikrein-10

1

2

High-throughput

0.691

High

318563

RHBT1
Rho-related BTB domain-containing protein 1

1

1

High-throughput

0.691

High

378993

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.691

High

379002

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

1

High-throughput

0.691

High

379018

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.691

High

122897

SGK1
Serine/threonine-protein kinase Sgk1

1

1

High-throughput

0.665

High

378944

LEG1
Galectin-1

1

1

High-throughput

0.665

High

378970

UCP2
Dicarboxylate carrier SLC25A8

2

0

High-throughput

0.660

High

141972

FCN1
Ficolin-1

1

0

High-throughput

0.656

High

378961

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.656

High

378965

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.656

High

378966

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.656

High

378977

CDK6
Cyclin-dependent kinase 6

1

0

High-throughput

0.656

High

379019

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.656

High

379047

NOX4
NADPH oxidase 4

1

0

High-throughput

0.656

High

379053

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.656

High

378954

ITPI2
Protein ITPRID2

3

0

High-throughput

0.638

High

379035

TM237
Transmembrane protein 237

3

0

High-throughput

0.638

High

379034

SNX27
Sorting nexin-27

2

3

High-throughput

0.628

High

378942

HBAT
Hemoglobin subunit theta-1

1

1

High-throughput

0.618

High

379008

SPNS3
Protein spinster homolog 3

1

1

High-throughput

0.618

High

379038

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.618

High

379052

KLF15
Krueppel-like factor 15

1

1

High-throughput

0.618

High

378937

PIGR
Polymeric immunoglobulin receptor

1

17

Small-scale

0.618

High

378943

GROA
Growth-regulated alpha protein

1

2

Small-scale

0.618

High

378945

IL8
Interleukin-8

1

2

Small-scale

0.618

High

378962

CXCL5
C-X-C motif chemokine 5

1

2

Small-scale

0.618

High

378967

LUM
Lumican

1

2

Small-scale

0.618

High

378969

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.618

High

378989

SCRIB
Protein scribble homolog

1

2

Small-scale

0.618

High

379041

RFIP5
Rab11 family-interacting protein 5

1

2

Small-scale

0.618

High

378950

RAB3B
Ras-related protein Rab-3B

1

0

Small-scale

0.614

High

62876

POTEF
POTE ankyrin domain family member F

1

0

Small-scale

0.586

High

141260

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.586

High

378941

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.586

High

378947

CCL5
C-C motif chemokine 5

1

0

Small-scale

0.586

High

378979

NOTC2
Neurogenic locus notch homolog protein 2

1

0

Small-scale

0.586

High

379012

PRS58
Serine protease 58

1

0

Small-scale

0.586

High

191895

MAGB4
Melanoma-associated antigen B4

1

0

High-throughput

0.578

High

378949

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.578

High

378964

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.578

High

378997

T176B
Transmembrane protein 176B

1

0

High-throughput

0.578

High

379011

ZN695
Zinc finger protein 695

1

0

High-throughput

0.578

High

379017

ZN491
Zinc finger protein 491

1

0

High-throughput

0.578

High

379046

COE2
Transcription factor COE2

1

0

High-throughput

0.578

High

378985

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.575

High

379016

FRMD1
FERM domain-containing protein 1

2

7

High-throughput

0.574

High

378987

CUL4A
Cullin-4A

1

4

High-throughput

0.553

High

378988

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.553

High

379007

RFIP1
Rab11 family-interacting protein 1

1

1

Small-scale

0.553

High

379025

MK15
Mitogen-activated protein kinase 15

1

3

High-throughput

0.553

High

379055

NINL
Ninein-like protein

1

2

High-throughput

0.553

High

378956

SC6A6
Sodium- and chloride-dependent taurine transporter

1

0

High-throughput

0.546

High

379033

LOXL4
Lysyl oxidase homolog 4

1

3

High-throughput

0.536

High

326395

ZN202
Zinc finger protein 202

1

0

Small-scale

0.517

High

378968

SC24C
Protein transport protein Sec24C

1

0

Small-scale

0.517

High

379021

KMT2C
Histone-lysine N-methyltransferase 2C

1

0

Small-scale

0.517

High

379051

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.517

High

379000

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.514

High

178884

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.513

High

379028

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

379031

PMEPA
Protein TMEPAI

1

0

High-throughput

0.513

High

379048

GKN1
Gastrokine-1

1

0

High-throughput

0.513

High

378981

RING1
E3 ubiquitin-protein ligase RING1

1

2

High-throughput

0.489

High

379009

AEBP2
Zinc finger protein AEBP2

1

1

High-throughput

0.489

High

379027

ZDH19
Palmitoyltransferase ZDHHC19

1

1

High-throughput

0.489

High

378948

K1C10
Keratin, type I cytoskeletal 10

1

1

Small-scale

0.479

High

378959

K1C9
Keratin, type I cytoskeletal 9

1

1

Small-scale

0.479

High

378960

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

Small-scale

0.479

High

378963

EFTU
Elongation factor Tu, mitochondrial

1

1

Small-scale

0.479

High

378991

NUMA1
Nuclear mitotic apparatus protein 1

1

2

Small-scale

0.479

High

379022

NBEA
Neurobeachin

1

1

Small-scale

0.479

High

379037

RANB9
Ran-binding protein 9

1

2

High-throughput

0.479

High

379056

E41L3
Band 4.1-like protein 3

1

4

Small-scale

0.479

High

61072

T131L
Transmembrane protein 131-like

1

0

Small-scale

0.458

High

225515

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.458

High

378938

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.458

High

378940

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

378951

FLNA
Filamin-A

1

0

Small-scale

0.458

High

378952

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

Small-scale

0.458

High

378958

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

378973

H4
Histone H4

1

0

Small-scale

0.458

High

378974

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.458

High

378982

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

379030

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

378939

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

Small-scale

0.437

High

378946

PYC
Pyruvate carboxylase, mitochondrial

1

4

Small-scale

0.437

High

378953

LAMA2
Laminin subunit alpha-2

1

11

Small-scale

0.437

High

378955

PML
Protein PML

1

1

High-throughput

0.437

High

378975

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.437

High

378978

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.437

High

378986

ACACA
Acetyl-CoA carboxylase 1

1

4

Small-scale

0.437

High

379010

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.437

High

379024

LNX1
E3 ubiquitin-protein ligase LNX

1

6

Small-scale

0.437

High

379036

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

Small-scale

0.437

High

379042

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

378976

TF2B
Transcription initiation factor IIB

3

0

High-throughput

0.347

High

378999

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

379023

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

67414

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.279

Low

133834

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.279

Low

335216

CXB5
Gap junction beta-5 protein

1

0

High-throughput

0.279

Low

354008

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

378971

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

378972

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.279

Low

378984

TWF1
Twinfilin-1

1

0

High-throughput

0.279

Low

378990

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

378994

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

High-throughput

0.279

Low

378995

PKHG6
Pleckstrin homology domain-containing family G member 6

1

0

High-throughput

0.279

Low

379003

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

379005

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

379006

PBIR3
PABIR family member 1

1

0

High-throughput

0.279

Low

379013

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.279

Low

379014

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.279

Low

379015

CJ053
UPF0728 protein C10orf53

1

0

High-throughput

0.279

Low

379026

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

0

High-throughput

0.279

Low

379029

CRGN
Gamma-crystallin N

1

0

High-throughput

0.279

Low

379039

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.279

Low

379040

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.279

Low

379049

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

0

High-throughput

0.279

Low

379054

NXT1
NTF2-related export protein 1

1

0

High-throughput

0.279

Low

379043

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

219839

SMAD6
Mothers against decapentaplegic homolog 6

1

0

Small-scale

0.249

Low

238340

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

277228

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

293015

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

378957

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

Small-scale

0.249

Low

378980

EF1A2
Elongation factor 1-alpha 2

1

0

Small-scale

0.249

Low

378983

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.249

Low

378992

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

378996

UD3A2
UDP-glucuronosyltransferase 3A2

1

0

Small-scale

0.249

Low

378998

KCD21
BTB/POZ domain-containing protein KCTD21

1

0

Small-scale

0.249

Low

379004

TATD1
Deoxyribonuclease TATDN1

1

0

Small-scale

0.249

Low

379020

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

379045

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.249

Low

379050

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025