Protein: DEF1
Neutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]

Gene: DEF1, DEFA1
Organism: Homo sapiens
Interactions: 114
UniProt ID: P59665

Gene Ontology (top 5):
GO:0002227 - innate immune response in mucosa
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005796 - Golgi lumen
GO:0006935 - chemotaxis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175342

PLXB2
Plexin-B2

2

5

High-throughput

0.628

High

183239

LAMA5
Laminin subunit alpha-5

2

6

High-throughput

0.628

High

215709

COCH
Cochlin

2

5

High-throughput

0.628

High

317559

SLIT2
Slit homolog 2 protein

2

2

High-throughput

0.628

High

448004

ITAV
Integrin alpha-V

2

2

High-throughput

0.628

High

462858

LAMB1
Laminin subunit beta-1

2

6

High-throughput

0.628

High

551779

CO6A1

2

3

High-throughput

0.628

High

562710

BMP1
Bone morphogenetic protein 1

2

4

High-throughput

0.628

High

586370

ARSB
Arylsulfatase B

2

5

High-throughput

0.628

High

611630

IBP2
Insulin-like growth factor-binding protein 2

2

3

High-throughput

0.628

High

654485

FBLN1
Fibulin-1

2

3

High-throughput

0.628

High

928760

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

2

2

High-throughput

0.628

High

937382

LAMB2
Laminin subunit beta-2

2

5

High-throughput

0.628

High

947979

TGBR3
Transforming growth factor beta receptor type 3

2

1

High-throughput

0.628

High

947980

COEA1
Collagen alpha-1(XIV) chain

2

1

High-throughput

0.628

High

947987

NID2
Nidogen-2

2

2

High-throughput

0.628

High

947989

LAMA3
Laminin subunit alpha-3

2

7

High-throughput

0.628

High

947990

T132A
Transmembrane protein 132A

2

1

High-throughput

0.628

High

948002

CILP2
Cartilage intermediate layer protein 2

2

1

High-throughput

0.628

High

948004

SULF2
Extracellular sulfatase Sulf-2

2

4

High-throughput

0.628

High

948008

PXDN
Peroxidasin homolog

2

1

High-throughput

0.628

High

948015

PADC1
Protease-associated domain-containing protein 1

2

2

High-throughput

0.628

High

948020

CNTP3
Contactin-associated protein-like 3

2

1

High-throughput

0.628

High

948022

SMOC1
SPARC-related modular calcium-binding protein 1

2

2

High-throughput

0.628

High

948025

CATF
Cathepsin F

2

2

High-throughput

0.628

High

948028

PLXA1
Plexin-A1

2

5

High-throughput

0.628

High

948033

LOXL2
Lysyl oxidase homolog 2

2

1

High-throughput

0.628

High

947973

DEF1
Neutrophil defensin 1

1

3

High-throughput

0.618

High

948019

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.602

High

299955

CBPD
Carboxypeptidase D

2

0

High-throughput

0.602

High

327105

NXPH4
Neurexophilin-4

2

0

High-throughput

0.602

High

366539

TPA
Tissue-type plasminogen activator

2

0

High-throughput

0.602

High

376776

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

2

0

High-throughput

0.602

High

441416

CHLE
Cholinesterase

2

0

High-throughput

0.602

High

565844

EF2
Elongation factor 2

2

0

High-throughput

0.602

High

705292

GRN
Progranulin

2

0

High-throughput

0.602

High

810595

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

0

High-throughput

0.602

High

833453

WNT5A
Protein Wnt-5a

2

0

High-throughput

0.602

High

841604

LIFR
Leukemia inhibitory factor receptor

2

0

High-throughput

0.602

High

947974

NPC2
NPC intracellular cholesterol transporter 2

2

0

High-throughput

0.602

High

947978

DIAC
Di-N-acetylchitobiase

2

0

High-throughput

0.602

High

947992

TKFC
Triokinase/FMN cyclase

2

0

High-throughput

0.602

High

948006

SCRB1
Scavenger receptor class B member 1

2

0

High-throughput

0.602

High

948013

LGMN
Legumain

2

0

High-throughput

0.602

High

948024

ERAP1
Endoplasmic reticulum aminopeptidase 1

2

0

High-throughput

0.602

High

948027

CEIP2
Cell surface hyaluronidase CEMIP2

2

0

High-throughput

0.602

High

948030

NOTC3
Neurogenic locus notch homolog protein 3

2

0

High-throughput

0.602

High

239485

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

2

1

High-throughput

0.574

High

269661

PLXA2
Plexin-A2

2

5

High-throughput

0.574

High

593827

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

2

2

High-throughput

0.574

High

873452

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

2

2

High-throughput

0.574

High

947982

PP2BA
Protein phosphatase 3 catalytic subunit alpha

2

2

High-throughput

0.574

High

947986

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

2

2

High-throughput

0.574

High

947999

SUSD1
Sushi domain-containing protein 1

2

7

High-throughput

0.574

High

948007

TM131
Transmembrane protein 131

2

1

High-throughput

0.574

High

948017

MCMBP
Mini-chromosome maintenance complex-binding protein

2

1

High-throughput

0.574

High

948021

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

2

2

High-throughput

0.574

High

948023

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

2

2

High-throughput

0.574

High

948034

LRP12
Low-density lipoprotein receptor-related protein 12

2

2

High-throughput

0.574

High

948026

UBQL2
Ubiquilin-2

2

2

High-throughput

0.553

High

249038

NRP2
Neuropilin-2

1

3

High-throughput

0.536

High

363058

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.536

High

756540

GALNS
N-acetylgalactosamine-6-sulfatase

1

4

High-throughput

0.536

High

774754

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

947991

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.536

High

948000

ARSK
Arylsulfatase K

1

4

High-throughput

0.536

High

948011

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

2

High-throughput

0.536

High

210737

KLK10
Kallikrein-10

1

0

High-throughput

0.513

High

261614

CATL2
Cathepsin L2

1

0

High-throughput

0.513

High

648271

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.513

High

733320

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

947976

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

0

High-throughput

0.513

High

947983

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

0

High-throughput

0.513

High

947984

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.513

High

947998

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.513

High

948010

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.513

High

376491

LDLR
Low-density lipoprotein receptor

1

2

High-throughput

0.489

High

473679

ITA5
Integrin alpha-5

1

2

High-throughput

0.489

High

947995

CAHD1
VWFA and cache domain-containing protein 1

1

2

High-throughput

0.489

High

948005

TTC13
Tetratricopeptide repeat protein 13

1

1

High-throughput

0.489

High

948018

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

2

High-throughput

0.489

High

891413

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.464

High

480376

MMP7
Matrilysin

1

1

Small-scale

0.445

High

894407

MMP14
Matrix metalloproteinase-14

1

1

Small-scale

0.445

High

948003

TEX14
Inactive serine/threonine-protein kinase TEX14

1

1

High-throughput

0.445

High

947996

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

136602

MANBA
Beta-mannosidase

2

0

High-throughput

0.328

High

269845

IGSF3
Immunoglobulin superfamily member 3

2

0

High-throughput

0.328

High

720406

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

2

0

High-throughput

0.328

High

947975

CANB1
Calcineurin subunit B type 1

2

0

High-throughput

0.328

High

947981

ZO1
Tight junction protein 1

2

0

High-throughput

0.328

High

947993

MKS3
Meckelin

2

0

High-throughput

0.328

High

947994

AB17B
Alpha/beta hydrolase domain-containing protein 17B

2

0

High-throughput

0.328

High

948001

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.328

High

948016

CNPY3
Protein canopy homolog 3

2

0

High-throughput

0.328

High

219805

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.279

Low

885462

MA2A2
Alpha-mannosidase 2x

1

0

High-throughput

0.279

Low

947977

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.279

Low

947985

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

947988

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.279

Low

947997

PLB1
Phospholipase B1, membrane-associated

1

0

High-throughput

0.279

Low

948009

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.279

Low

948029

FBX4
F-box only protein 4

1

0

High-throughput

0.279

Low

277283

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

371598

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

948014

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.249

Low

948031

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

948032

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

0

Small-scale

0.249

Low

261783

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.238

Low

599979

ZNF16
Zinc finger protein 16

1

0

Small-scale

0.238

Low

210183

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

High-throughput

0.232

Low

270788

ROCK2
Rho-associated protein kinase 2

1

0

High-throughput

0.232

Low

948012

SRPK1
SRSF protein kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025