Protein: T23O
Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)

Gene: T23O, TDO2
Organism: Homo sapiens
Interactions: 29
UniProt ID: P48775

Gene Ontology (top 5):
GO:0004833 - tryptophan 2,3-dioxygenase activity
GO:0005829 - cytosol
GO:0016597 - amino acid binding
GO:0019441 - L-tryptophan catabolic process to kynurenine
GO:0019442 - L-tryptophan catabolic process to acetyl-CoA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

877743

T23O
Tryptophan 2,3-dioxygenase

4

1

High-throughput

0.904

High

341240

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

7

0

High-throughput

0.721

High

140174

SDCB1
Syntenin-1

4

1

High-throughput

0.705

High

877755

MOB1A
MOB kinase activator 1A

3

1

High-throughput

0.675

High

877757

NGB
Neuroglobin

3

0

High-throughput

0.646

High

877754

SDCB2
Syntenin-2

2

2

High-throughput

0.628

High

255592

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

2

0

High-throughput

0.626

High

445513

IF4E
Eukaryotic translation initiation factor 4E

2

0

High-throughput

0.618

High

631831

NR1D1
Nuclear receptor subfamily 1 group D member 1

2

0

High-throughput

0.580

High

877758

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

877749

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.573

High

877745

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.541

High

680811

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.536

High

229982

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.493

High

697802

CALR
Calreticulin

1

0

High-throughput

0.493

High

787933

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

877752

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.493

High

385545

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

877744

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

877748

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.417

High

877746

ZFY26
Zinc finger FYVE domain-containing protein 26

3

0

High-throughput

0.352

High

877756

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

3

0

High-throughput

0.348

High

877750

P20D2
Xaa-Arg dipeptidase

2

0

High-throughput

0.316

High

877751

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

555950

CADH1
Cadherin-1

1

0

High-throughput

0.268

Low

246473

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.265

Low

877753

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.265

Low

877747

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025