Protein: IF4E
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)

Gene: IF4E, EIF4E
Organism: Homo sapiens
Interactions: 178
UniProt ID: P06730

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000339 - RNA cap binding
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0000932 - P-body
GO:0001662 - behavioral fear response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445546

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

58

15

Small-scale

0.997

High

445547

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

18

15

Small-scale

0.989

High

445603

4ET
Eukaryotic translation initiation factor 4E transporter

14

2

Small-scale

0.986

High

251169

4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3

8

15

Small-scale

0.977

High

445534

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

34

18

Small-scale

0.770

High

216046

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

9

18

Small-scale

0.754

High

445521

IF4A1
Eukaryotic initiation factor 4A-I

9

5

Small-scale

0.754

High

445498

PML
Protein PML

7

1

Small-scale

0.744

High

445574

ANKH1
Ankyrin repeat and KH domain-containing protein 1

6

1

Small-scale

0.726

High

445518

EIF3B
Eukaryotic translation initiation factor 3 subunit B

5

4

Small-scale

0.718

High

445558

KANK2
KN motif and ankyrin repeat domain-containing protein 2

4

2

High-throughput

0.705

High

66983

I4E1B
Eukaryotic translation initiation factor 4E type 1B

1

3

High-throughput

0.691

High

445619

ANGE1
Protein angel homolog 1

5

0

High-throughput

0.686

High

445489

TRI27
Zinc finger protein RFP

3

2

High-throughput

0.676

High

445551

IF4A2
Eukaryotic initiation factor 4A-II

3

5

High-throughput

0.667

High

445533

HHEX
Hematopoietically-expressed homeobox protein HHEX

3

3

Small-scale

0.664

High

141283

DDX3X
ATP-dependent RNA helicase DDX3X

3

2

Small-scale

0.657

High

131291

EIF3F
Eukaryotic translation initiation factor 3 subunit F

3

3

Small-scale

0.656

High

445554

ELAV1
ELAV-like protein 1

3

3

Small-scale

0.650

High

445556

UBX11
UBX domain-containing protein 11

2

1

High-throughput

0.646

High

445525

RS6
Small ribosomal subunit protein eS6

3

2

Small-scale

0.640

High

295074

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

5

High-throughput

0.628

High

445487

PABP1
Polyadenylate-binding protein 1

2

2

Small-scale

0.621

High

445513

T23O
Tryptophan 2,3-dioxygenase

2

0

High-throughput

0.618

High

445509

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

Small-scale

0.602

High

187861

EIF3H
Eukaryotic translation initiation factor 3 subunit H

2

3

High-throughput

0.601

High

445507

MTOR
Serine/threonine-protein kinase mTOR

2

2

Small-scale

0.601

High

189089

IPO8
Importin-8

2

0

Small-scale

0.598

High

172405

XPO1
Exportin-1

2

2

Small-scale

0.595

High

445550

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

0

Small-scale

0.585

High

445495

DDX6
Probable ATP-dependent RNA helicase DDX6

2

6

High-throughput

0.584

High

445510

DCC
Netrin receptor DCC

2

2

Small-scale

0.584

High

445529

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

2

18

Small-scale

0.584

High

445625

YTHD2
YTH domain-containing family protein 2

2

2

Small-scale

0.584

High

445532

CD83
CD83 antigen

1

0

High-throughput

0.584

High

445545

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

Small-scale

0.578

High

395329

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

445499

HXA9
Homeobox protein Hox-A9

1

1

Small-scale

0.561

High

445618

CHIP
E3 ubiquitin-protein ligase CHIP

2

0

Small-scale

0.559

High

207729

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

Small-scale

0.554

High

445582

GEMI5
Gem-associated protein 5

1

1

Small-scale

0.536

High

445484

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.536

High

445490

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

2

High-throughput

0.536

High

445494

KS6B1
Ribosomal protein S6 kinase beta-1

1

1

Small-scale

0.536

High

445506

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.536

High

445511

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

445527

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.536

High

445537

NCBP1
Nuclear cap-binding protein subunit 1

1

1

Small-scale

0.536

High

445543

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.536

High

445548

DX39B
Spliceosome RNA helicase DDX39B

1

3

Small-scale

0.536

High

445566

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.536

High

445580

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.536

High

445585

PSPC1
Paraspeckle component 1

1

6

High-throughput

0.536

High

445591

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.536

High

445593

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

445596

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.536

High

445620

WDR3
WD repeat-containing protein 3

1

3

High-throughput

0.536

High

445535

EMX2
Homeobox protein EMX2

1

2

Small-scale

0.534

High

445594

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

4

Small-scale

0.534

High

445589

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.530

High

445486

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.528

High

445597

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

Small-scale

0.527

High

445614

PRDM4
PR domain zinc finger protein 4

1

0

High-throughput

0.518

High

445528

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.515

High

62886

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

187629

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

271397

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

303384

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

445512

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

445515

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

445517

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

445519

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

445523

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

445552

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

445568

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.513

High

445606

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

445608

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

445612

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

445621

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

445622

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

445624

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

281277

GGYF1
GRB10-interacting GYF protein 1

1

9

Small-scale

0.501

High

421306

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

445493

HME2
Homeobox protein engrailed-2

1

3

Small-scale

0.501

High

445500

TLX1
T-cell leukemia homeobox protein 1

1

5

Small-scale

0.501

High

445501

OTX2
Homeobox protein OTX2

1

1

Small-scale

0.501

High

445564

GGYF2
GRB10-interacting GYF protein 2

1

9

Small-scale

0.501

High

445569

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

Small-scale

0.501

High

445595

RBM4
RNA-binding protein 4

1

4

Small-scale

0.500

High

445508

CASP3
Caspase-3

1

0

High-throughput

0.493

High

445520

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

135019

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

156585

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

4

High-throughput

0.479

High

169896

AURKA
Aurora kinase A

1

1

Small-scale

0.479

High

240496

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

289405

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

3

Small-scale

0.479

High

315018

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

321409

PRP6
Pre-mRNA-processing factor 6

1

1

Small-scale

0.479

High

345263

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

445496

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

Small-scale

0.479

High

445497

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.479

High

445502

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

445516

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

445522

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

445524

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

445526

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.479

High

445530

SRSF3
Serine/arginine-rich splicing factor 3

1

5

Small-scale

0.479

High

445531

U2AF1
Splicing factor U2AF 35 kDa subunit

1

1

Small-scale

0.479

High

445536

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.479

High

445540

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.479

High

445541

PAK2
Serine/threonine-protein kinase PAK 2

1

1

High-throughput

0.479

High

445542

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

445544

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

445549

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

4

Small-scale

0.479

High

445553

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

445557

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

445565

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

445570

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

445571

PATL1
Protein PAT1 homolog 1

1

2

High-throughput

0.479

High

445576

TRI22
E3 ubiquitin-protein ligase TRIM22

1

2

Small-scale

0.479

High

445577

RPTOR
Regulatory-associated protein of mTOR

1

3

Small-scale

0.479

High

445587

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

445588

CELF1
CUGBP Elav-like family member 1

1

3

High-throughput

0.479

High

445599

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

445605

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

445611

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

445617

PRP19
Pre-mRNA-processing factor 19

1

3

Small-scale

0.479

High

445623

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.479

High

445626

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

193945

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

285776

SF3B1
Splicing factor 3B subunit 1

1

0

Small-scale

0.458

High

293066

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

375089

RASK
GTPase KRas

1

0

High-throughput

0.458

High

445488

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

445538

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

Small-scale

0.458

High

445539

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

445555

HSPB2
Heat shock protein beta-2

1

0

Small-scale

0.458

High

445559

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

445560

TIGD7
Tigger transposable element-derived protein 7

1

0

High-throughput

0.458

High

445562

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.458

High

445572

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

Small-scale

0.458

High

445578

OTU6B
Deubiquitinase OTUD6B

1

0

Small-scale

0.458

High

445584

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

Small-scale

0.458

High

445586

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

445590

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

445592

CHOLN
Protein cholesin

1

0

High-throughput

0.458

High

445601

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

445602

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

445604

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.458

High

445607

AATF
Protein AATF

1

0

High-throughput

0.458

High

445613

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

Small-scale

0.458

High

400123

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

445503

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

445504

IRS1
Insulin receptor substrate 1

1

1

Small-scale

0.445

High

445600

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

3

Small-scale

0.445

High

445615

AGO2
Protein argonaute-2

1

4

Small-scale

0.445

High

445491

VINC
Vinculin

1

0

High-throughput

0.438

High

445567

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.437

High

445575

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.437

High

445598

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.437

High

171388

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

220558

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

249950

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.426

High

445485

CH088
Uncharacterized protein C8orf88

1

0

High-throughput

0.426

High

445492

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

445583

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

445609

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.426

High

445610

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

0

High-throughput

0.426

High

445616

INT6
Integrator complex subunit 6

1

0

Small-scale

0.426

High

445563

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

445514

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

445505

ACVL1
Activin receptor type-1-like

1

0

Small-scale

0.292

High

445581

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

411187

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

133420

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.232

Low

445561

ZNT6
Zinc transporter 6

1

0

High-throughput

0.232

Low

445573

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.232

Low

445579

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025