Protein: EZH1
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)

Gene: EZH1
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q92800

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

268202

EED
Polycomb protein EED

11

20

Small-scale

0.977

High

1063529

SUZ12
Polycomb protein SUZ12

10

11

Small-scale

0.976

High

1080189

EZH2
Histone-lysine N-methyltransferase EZH2

8

19

Small-scale

0.964

High

997839

RBBP4
Histone-binding protein RBBP4

3

20

High-throughput

0.871

High

1083337

RBBP7
Histone-binding protein RBBP7

3

20

High-throughput

0.871

High

1134176

PHF19
PHD finger protein 19

4

20

High-throughput

0.704

High

1271092

JARD2
Protein Jumonji

4

17

Small-scale

0.704

High

198028

PHF1
PHD finger protein 1

4

20

Small-scale

0.699

High

1271107

DCA13
DDB1- and CUL4-associated factor 13

1

15

High-throughput

0.691

High

1168986

AEBP2
Zinc finger protein AEBP2

3

18

High-throughput

0.675

High

1271119

MTF2
Metal-response element-binding transcription factor 2

3

20

High-throughput

0.675

High

1271097

LCOR
Ligand-dependent corepressor

3

5

High-throughput

0.662

High

62827

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

2

20

High-throughput

0.628

High

585025

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

Small-scale

0.618

High

1271091

EZH1
Histone-lysine N-methyltransferase EZH1

1

18

Small-scale

0.618

High

224822

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

5

High-throughput

0.536

High

596796

CD11B
Cyclin-dependent kinase 11B

1

4

High-throughput

0.536

High

632837

TYY1
Transcriptional repressor protein YY1

1

12

High-throughput

0.536

High

820995

PRC2A
Protein PRRC2A

1

20

High-throughput

0.536

High

848098

MECP2
Methyl-CpG-binding protein 2

1

12

High-throughput

0.536

High

1018419

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

8

High-throughput

0.536

High

1039734

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1049500

SAFB2
Scaffold attachment factor B2

1

9

High-throughput

0.536

High

1051996

ELOA1
Elongin-A

1

8

High-throughput

0.536

High

1120417

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.536

High

1132718

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

19

High-throughput

0.536

High

1183339

DDX46
Probable ATP-dependent RNA helicase DDX46

1

7

High-throughput

0.536

High

1191701

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

19

High-throughput

0.536

High

1198914

RBM23
Probable RNA-binding protein 23

1

7

High-throughput

0.536

High

1217330

VRK3
Serine/threonine-protein kinase VRK3

1

3

High-throughput

0.536

High

1219991

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.536

High

1234226

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

1

High-throughput

0.536

High

1242561

RB15B
Putative RNA-binding protein 15B

1

7

High-throughput

0.536

High

1250970

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.536

High

1260467

CATIN
Splicing factor Cactin

1

2

High-throughput

0.536

High

1268321

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

7

High-throughput

0.536

High

1271099

SCAFB
Protein SCAF11

1

8

High-throughput

0.536

High

1271100

BUD13
BUD13 homolog

1

5

High-throughput

0.536

High

1271101

DIDO1
Death-inducer obliterator 1

1

20

High-throughput

0.536

High

1271102

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.536

High

1271103

GTPB4
GTP-binding protein 4

1

4

High-throughput

0.536

High

1271104

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.536

High

1271108

ARGL1
Arginine and glutamate-rich protein 1

1

1

High-throughput

0.536

High

1271109

SLTM
SAFB-like transcription modulator

1

13

High-throughput

0.536

High

1271111

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

4

High-throughput

0.536

High

1271112

CDK12
Cyclin-dependent kinase 12

1

6

High-throughput

0.536

High

1271113

RBM27
RNA-binding protein 27

1

10

High-throughput

0.536

High

1271115

INT6
Integrator complex subunit 6

1

1

High-throughput

0.536

High

1271116

TPX2
Targeting protein for Xklp2

1

6

High-throughput

0.536

High

1271117

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

16

High-throughput

0.536

High

1271118

WBP11
WW domain-binding protein 11

1

13

High-throughput

0.536

High

199795

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.513

High

880031

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.513

High

1024928

RED
Protein Red

1

0

High-throughput

0.513

High

1128513

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.513

High

1239258

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.513

High

1243729

PPHLN
Periphilin-1

1

0

High-throughput

0.513

High

1250739

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1261472

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1271094

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.513

High

1271096

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.513

High

1271105

ESF1
ESF1 homolog

1

0

High-throughput

0.513

High

1271110

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.513

High

1271114

ZO2
Tight junction protein ZO-2

1

0

High-throughput

0.513

High

62160

RCCD1
RCC1 domain-containing protein 1

1

4

High-throughput

0.489

High

858191

BIEA
Biliverdin reductase A

1

1

High-throughput

0.489

High

1093542

SKDA1
SKI/DACH domain-containing protein 1

1

5

High-throughput

0.489

High

1138136

PR38B
Pre-mRNA-splicing factor 38B

1

2

High-throughput

0.489

High

1271095

RMXL1
RNA binding motif protein, X-linked-like-1

1

10

High-throughput

0.489

High

1271106

CHM1A
Charged multivesicular body protein 1a

1

2

High-throughput

0.489

High

265236

SAP30
Histone deacetylase complex subunit SAP30

1

2

High-throughput

0.479

High

265692

E2F6
Transcription factor E2F6

1

6

Small-scale

0.479

High

486944

MYBB
Myb-related protein B

1

9

High-throughput

0.479

High

631536

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

798961

GATA4
Transcription factor GATA-4

1

9

Small-scale

0.479

High

1071484

ZMY11
Zinc finger MYND domain-containing protein 11

1

20

Small-scale

0.479

High

1271093

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1271098

PWP2A
PWWP domain-containing protein 2A

1

20

High-throughput

0.479

High

1119824

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.458

High

310206

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.438

High

1115846

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024