Protein: DCP1A
mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)

Gene: DCP1A
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q9NPI6

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1306924

DCP2
m7GpppN-mRNA hydrolase

15

3

Small-scale

0.987

High

1446475

PNRC2
Proline-rich nuclear receptor coactivator 2

10

3

Small-scale

0.978

High

1316194

DCP1B
mRNA-decapping enzyme 1B

7

10

Small-scale

0.963

High

1085970

PNRC1
Proline-rich nuclear receptor coactivator 1

3

3

High-throughput

0.861

High

1446474

DCP1A
mRNA-decapping enzyme 1A

2

9

Small-scale

0.841

High

1390411

EDC3
Enhancer of mRNA-decapping protein 3

15

3

Small-scale

0.764

High

684403

DDX6
Probable ATP-dependent RNA helicase DDX6

11

7

Small-scale

0.760

High

1241505

EDC4
Enhancer of mRNA-decapping protein 4

11

7

Small-scale

0.759

High

1106717

SMAD4
Mothers against decapentaplegic homolog 4

5

3

Small-scale

0.726

High

336785

BAG4
BAG family molecular chaperone regulator 4

5

1

High-throughput

0.723

High

1370122

RENT1
Regulator of nonsense transcripts 1

4

3

Small-scale

0.702

High

1123132

FHL2
Four and a half LIM domains protein 2

4

7

High-throughput

0.698

High

541061

PIM1
Serine/threonine-protein kinase pim-1

4

2

High-throughput

0.691

High

966906

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

990770

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.656

High

1287134

PATL1
Protein PAT1 homolog 1

3

4

Small-scale

0.656

High

730271

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.650

High

1049815

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1316464

XRN1
5'-3' exoribonuclease 1

3

3

Small-scale

0.642

High

1336305

LS14A
Protein LSM14 homolog A

3

8

Small-scale

0.640

High

791750

SYUA
Alpha-synuclein

3

2

Small-scale

0.633

High

483225

CLCA
Clathrin light chain A

2

5

High-throughput

0.611

High

688325

TTP
mRNA decay activator protein ZFP36

2

3

Small-scale

0.611

High

972030

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.611

High

1446497

MARF1
Meiosis regulator and mRNA stability factor 1

2

1

High-throughput

0.611

High

1395643

RITA1
RBPJ-interacting and tubulin-associated protein 1

2

0

High-throughput

0.601

High

1094633

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

1

High-throughput

0.601

High

243015

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

891808

GSK3B
Glycogen synthase kinase-3 beta

2

6

High-throughput

0.584

High

1275694

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

5

Small-scale

0.584

High

848004

RAD52
DNA repair protein RAD52 homolog

2

0

High-throughput

0.580

High

855766

CRK
Adapter molecule crk

2

8

High-throughput

0.571

High

1366346

FAN
Protein FAN

1

4

Small-scale

0.552

High

928894

LIPR2
Pancreatic lipase-related protein 2

2

2

High-throughput

0.549

High

691858

MK03
Mitogen-activated protein kinase 3

1

3

High-throughput

0.541

High

178514

TBX3
T-box transcription factor TBX3

1

4

High-throughput

0.536

High

483398

CLCB
Clathrin light chain B

1

5

High-throughput

0.536

High

542664

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

650974

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

8

High-throughput

0.536

High

705564

GRN
Progranulin

1

1

High-throughput

0.536

High

855943

CRKL
Crk-like protein

1

7

High-throughput

0.536

High

1026240

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.536

High

1038360

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

1

High-throughput

0.536

High

1116036

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

647408

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.513

High

956505

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

1347492

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.513

High

1446485

TRM6
tRNA

1

0

High-throughput

0.513

High

1446499

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

1446502

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

344570

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.508

High

1446491

TTF2
Transcription termination factor 2

1

7

Small-scale

0.508

High

3680

NBDY
Negative regulator of P-body association

1

1

Small-scale

0.500

High

1257140

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.481

High

64909

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.479

High

124972

GTPB1
GTP-binding protein 1

1

1

High-throughput

0.479

High

129454

MEN1
Menin

1

1

High-throughput

0.479

High

168568

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

1

High-throughput

0.479

High

169762

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.479

High

173409

XPO1
Exportin-1

1

3

High-throughput

0.479

High

175221

SC16A
Protein transport protein Sec16A

1

6

High-throughput

0.479

High

176556

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

180936

TIF1A
Transcription intermediary factor 1-alpha

1

6

Small-scale

0.479

High

188040

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

1

Small-scale

0.479

High

246972

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

273936

CNOT3
CCR4-NOT transcription complex subunit 3

1

4

High-throughput

0.479

High

349254

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.479

High

373226

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

412655

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

414676

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

550482

PABP1
Polyadenylate-binding protein 1

1

5

High-throughput

0.479

High

589768

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

607130

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

651439

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

691459

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

714443

PML
Protein PML

1

4

High-throughput

0.479

High

730904

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

761521

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

862480

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

878565

PAXI
Paxillin

1

7

High-throughput

0.479

High

891322

GSK3A
Glycogen synthase kinase-3 alpha

1

5

High-throughput

0.479

High

908177

KS6A3
Ribosomal protein S6 kinase alpha-3

1

1

High-throughput

0.479

High

986746

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1096824

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

1102108

PABP4
Polyadenylate-binding protein 4

1

5

High-throughput

0.479

High

1110106

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

1114377

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1149380

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1151084

PCH2
Pachytene checkpoint protein 2 homolog

1

1

High-throughput

0.479

High

1156222

ZYX
Zyxin

1

8

High-throughput

0.479

High

1187083

LSM12
Protein LSM12

1

1

High-throughput

0.479

High

1225082

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

3

High-throughput

0.479

High

1241595

CEP85
Centrosomal protein of 85 kDa

1

2

High-throughput

0.479

High

1252398

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1255660

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1258044

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

6

High-throughput

0.479

High

1276825

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1280521

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1280750

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.479

High

1289644

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1322653

RPTOR
Regulatory-associated protein of mTOR

1

3

High-throughput

0.479

High

1322796

CNTRB
Centrobin

1

1

High-throughput

0.479

High

1324920

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

1334953

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1336854

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

10

High-throughput

0.479

High

1339726

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1350187

ALMS1
Centrosome-associated protein ALMS1

1

5

High-throughput

0.479

High

1359605

ATX2L
Ataxin-2-like protein

1

7

High-throughput

0.479

High

1360089

PALLD
Palladin

1

2

High-throughput

0.479

High

1363990

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1367354

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1369395

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

Small-scale

0.479

High

1372012

LPP
Lipoma-preferred partner

1

8

High-throughput

0.479

High

1406498

ATX2
Ataxin-2

1

8

High-throughput

0.479

High

1407475

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.479

High

1416468

LS14B
Protein LSM14 homolog B

1

5

High-throughput

0.479

High

1419541

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

High-throughput

0.479

High

1433969

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1437066

AGO3
Protein argonaute-3

1

4

High-throughput

0.479

High

1438029

RC3H2
Roquin-2

1

7

High-throughput

0.479

High

1438863

MOV10
Helicase MOV-10

1

3

High-throughput

0.479

High

1439100

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

11

High-throughput

0.479

High

1446478

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

1446483

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

1446486

RCOR1
REST corepressor 1

1

6

High-throughput

0.479

High

1446487

AGO2
Protein argonaute-2

1

4

High-throughput

0.479

High

1446488

AGO1
Protein argonaute-1

1

4

High-throughput

0.479

High

1446492

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.479

High

1446493

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

8

High-throughput

0.479

High

1446494

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

1

High-throughput

0.479

High

1446495

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

1446496

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1446498

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

1446501

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

64130

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

294373

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

445601

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

467967

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.458

High

831479

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

929838

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1135819

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1136950

ABRX2
BRISC complex subunit Abraxas 2

1

0

High-throughput

0.458

High

1178398

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1208586

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1215425

TUT4
Terminal uridylyltransferase 4

1

0

High-throughput

0.458

High

1337471

DUS18
Dual specificity protein phosphatase 18

1

0

High-throughput

0.458

High

1407893

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1435329

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1446476

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

1446479

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1446482

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.458

High

1446484

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.458

High

1446490

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1234968

PKHA7
Pleckstrin homology domain-containing family A member 7

1

6

High-throughput

0.445

High

1258590

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

769254

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1384450

PF21A
PHD finger protein 21A

1

8

High-throughput

0.437

High

1446500

KCTD3
BTB/POZ domain-containing protein KCTD3

1

4

High-throughput

0.437

High

347352

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.426

High

553079

PIP
Prolactin-inducible protein

1

0

High-throughput

0.426

High

1199707

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1446477

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

0

High-throughput

0.426

High

1311932

FBX16
F-box only protein 16

1

3

High-throughput

0.407

High

1396454

F167A
Protein FAM167A

1

1

High-throughput

0.407

High

1446489

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.407

High

295966

PPR37
Protein phosphatase 1 regulatory subunit 37

1

0

High-throughput

0.279

Low

932947

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1347094

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.279

Low

1446481

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.279

Low

1439168

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

1446480

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025