Protein: MLH3
DNA mismatch repair protein MLH3 (MutL protein homolog 3)

Gene: MLH3
Organism: Saccharomyces cerevisiae S288C
Interactions: 145
UniProt ID: Q12083

Gene Ontology (top 5):
GO:0000710 - meiotic mismatch repair
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006298 - mismatch repair
GO:0007131 - reciprocal meiotic recombination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

807649

MLH1
DNA mismatch repair protein MLH1

13

14

Small-scale

0.983

High

1084259

MSH5
MutS protein homolog 5

1

20

Small-scale

0.647

High

571284

PMS1
DNA mismatch repair protein PMS1

1

14

High-throughput

0.618

High

1084256

MLH3
DNA mismatch repair protein MLH3

1

14

High-throughput

0.618

High

546666

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.575

High

742632

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.575

High

820070

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.575

High

763301

SGS1
ATP-dependent helicase SGS1

1

2

Small-scale

0.534

High

924680

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

0

High-throughput

0.513

High

416486

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

452988

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.500

High

592566

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.500

High

607796

HXKG
Glucokinase-1

1

1

High-throughput

0.500

High

948689

ACT
Actin

1

2

High-throughput

0.500

High

408363

GAL1
Galactokinase

1

0

High-throughput

0.479

High

531423

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

626919

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

440980

CDC7
Cell division control protein 7

1

2

High-throughput

0.479

High

581912

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

586494

PCNA
Proliferating cell nuclear antigen

1

5

High-throughput

0.479

High

594624

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

614854

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

4

High-throughput

0.479

High

616460

SEC18
Vesicular-fusion protein SEC18

1

2

High-throughput

0.479

High

632603

DBP3
ATP-dependent RNA helicase DBP3

1

1

High-throughput

0.479

High

708479

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

721427

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.479

High

740026

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

High-throughput

0.479

High

796854

SIF2
SIR4-interacting protein SIF2

1

1

High-throughput

0.479

High

800830

RCK2
Serine/threonine-protein kinase RCK2

1

2

High-throughput

0.479

High

801030

RFC1
Replication factor C subunit 1

1

6

Small-scale

0.479

High

814746

EXO1
Exodeoxyribonuclease 1

1

5

High-throughput

0.479

High

825051

MET18
DNA repair/transcription protein MET18/MMS19

1

3

High-throughput

0.479

High

826920

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

865595

ARP3
Actin-related protein 3

1

3

High-throughput

0.479

High

924274

RHO5
GTP-binding protein RHO5

1

2

High-throughput

0.479

High

1041887

RLI1
Translation initiation factor RLI1

1

1

High-throughput

0.479

High

1043988

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

1

High-throughput

0.479

High

1044828

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

1062755

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.479

High

1084257

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.479

High

368258

TRP
Tryptophan synthase

1

0

High-throughput

0.458

High

402246

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.458

High

444649

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.458

High

452603

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

649249

SAN1
Protein SAN1

1

0

High-throughput

0.458

High

673315

ADP1
Probable ATP-dependent permease

1

0

High-throughput

0.458

High

725903

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.458

High

726593

VATC
V-type proton ATPase subunit C

1

0

High-throughput

0.458

High

733685

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

734302

PYC2
Pyruvate carboxylase 2

1

0

High-throughput

0.458

High

735803

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.458

High

748152

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.458

High

754455

NPL4
Nuclear protein localization protein 4

1

0

High-throughput

0.458

High

763391

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

779812

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.458

High

794887

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.458

High

797256

HSL7
Protein arginine N-methyltransferase HSL7

1

0

High-throughput

0.458

High

802021

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

High-throughput

0.458

High

802710

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.458

High

802816

SYRM
Arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

813317

FHP
Flavohemoprotein

1

0

High-throughput

0.458

High

828622

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.458

High

836386

THI6
Thiamine biosynthetic bifunctional enzyme [Includes: Thiamine-phosphate synthase

1

0

High-throughput

0.458

High

849563

GCN20
Protein GCN20

1

0

High-throughput

0.458

High

850635

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.458

High

916868

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

918233

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.458

High

923785

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

0

High-throughput

0.458

High

1044277

FIN1
Filament protein FIN1

1

0

High-throughput

0.458

High

1046882

APC4
Anaphase-promoting complex subunit 4

1

0

High-throughput

0.458

High

1050244

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.458

High

1052981

VID22
Vacuolar import and degradation protein 22

1

0

High-throughput

0.458

High

1053929

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1055427

IWS1
Transcription factor SPN1

1

0

High-throughput

0.458

High

1064650

ESA1
Histone acetyltransferase ESA1

1

0

High-throughput

0.458

High

1084258

CFT2
Cleavage factor two protein 2

1

0

High-throughput

0.458

High

1084261

IES3
Ino eighty subunit 3

1

0

High-throughput

0.458

High

1084264

H2AZ
Histone H2A.Z

1

0

High-throughput

0.458

High

1084265

YPK9
Vacuolar cation-transporting ATPase YPK9

1

0

High-throughput

0.458

High

676452

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

557645

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.437

High

793312

YMC2
Carrier protein YMC2, mitochondrial

1

1

High-throughput

0.437

High

817653

UTP7
U3 small nucleolar RNA-associated protein 7

1

1

High-throughput

0.437

High

917643

MLC1
Myosin light chain 1

1

1

High-throughput

0.437

High

919621

MTM1
Mitochondrial carrier protein MTM1

1

1

High-throughput

0.437

High

1025062

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

1038561

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.437

High

1060851

PSR2
Probable phosphatase PSR2

1

1

High-throughput

0.437

High

1065529

AP3D
AP-3 complex subunit delta

1

4

High-throughput

0.437

High

453321

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.279

Low

1084260

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.265

Low

368770

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

386906

TBB
Tubulin beta chain

1

0

High-throughput

0.261

Low

555171

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

150002

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

150082

COQ4
Ubiquinone biosynthesis protein COQ4, mitochondrial

1

0

High-throughput

0.249

Low

383011

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

470171

SPS2
Sporulation-specific protein 2

1

0

High-throughput

0.249

Low

542735

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.249

Low

554544

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

568744

RSR1
Ras-related protein RSR1

1

0

High-throughput

0.249

Low

672178

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.249

Low

727689

TPS2
Trehalose-phosphatase

1

0

High-throughput

0.249

Low

743491

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.249

Low

746967

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

752032

PGM1
Phosphoglucomutase 1

1

0

High-throughput

0.249

Low

758168

CASP
Protein CASP

1

0

High-throughput

0.249

Low

763168

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.249

Low

775998

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.249

Low

789817

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.249

Low

792751

ETR1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

0

High-throughput

0.249

Low

794865

MRX3
MIOREX complex component 3

1

0

High-throughput

0.249

Low

796834

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.249

Low

798707

YB8B
Uncharacterized transporter YBR287W

1

0

High-throughput

0.249

Low

803466

OSH7
Oxysterol-binding protein homolog 7

1

0

High-throughput

0.249

Low

803513

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.249

Low

804834

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

805740

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.249

Low

816607

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.249

Low

817558

AIM9
Altered inheritance of mitochondria protein 9, mitochondrial

1

0

High-throughput

0.249

Low

823454

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.249

Low

824682

COA1
Cytochrome c oxidase assembly factor 1

1

0

High-throughput

0.249

Low

825274

YIK8
Putative zinc metalloproteinase YIL108W

1

0

High-throughput

0.249

Low

849669

EMP47
Protein EMP47

1

0

High-throughput

0.249

Low

850940

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.249

Low

863232

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.249

Low

863594

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

High-throughput

0.249

Low

894339

SIP18
Protein SIP18

1

0

High-throughput

0.249

Low

902684

RL9B
Large ribosomal subunit protein uL6B

1

0

High-throughput

0.249

Low

923048

YN8O
Uncharacterized protein YNR040W

1

0

High-throughput

0.249

Low

1044548

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.249

Low

1044998

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.249

Low

1050108

NTE1
Lysophospholipase NTE1

1

0

High-throughput

0.249

Low

1050272

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

0

High-throughput

0.249

Low

1052334

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.249

Low

1053477

STE23
A-factor-processing enzyme

1

0

High-throughput

0.249

Low

1056557

CDA1
Chitin deacetylase 1

1

0

High-throughput

0.249

Low

1059209

MRX9
MIOREX complex component 9

1

0

High-throughput

0.249

Low

1060329

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

0

High-throughput

0.249

Low

1062803

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.249

Low

1064744

GPN2
GPN-loop GTPase 2

1

0

High-throughput

0.249

Low

1065560

PGC1
Phosphatidylglycerol phospholipase C

1

0

High-throughput

0.249

Low

1084262

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.249

Low

1084263

PRM4
Pheromone-regulated membrane protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025