Protein: DC1L1
Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)

Gene: DC1L1, DYNC1LI1
Organism: Homo sapiens
Interactions: 186
UniProt ID: Q9Y6G9

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0003723 - RNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1124100

DYHC1
Cytoplasmic dynein 1 heavy chain 1

11

2

High-throughput

0.977

High

1490780

NINL
Ninein-like protein

3

3

High-throughput

0.827

High

210622

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

2

2

High-throughput

0.811

High

1104289

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

5

8

High-throughput

0.720

High

991967

DYLT1
Dynein light chain Tctex-type 1

5

2

High-throughput

0.718

High

156683

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

5

9

Small-scale

0.714

High

1315935

RASEF
Ras and EF-hand domain-containing protein

1

2

High-throughput

0.691

High

1123894

DCTN1
Dynactin subunit 1

4

3

Small-scale

0.686

High

991791

DYL1
Dynein light chain 1, cytoplasmic

3

3

High-throughput

0.675

High

845370

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

3

2

High-throughput

0.667

High

1446097

DLRB1
Dynein light chain roadblock-type 1

3

1

High-throughput

0.667

High

1390767

DYL2
Dynein light chain 2, cytoplasmic

3

3

High-throughput

0.650

High

243447

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.640

High

907982

DYLT3
Dynein light chain Tctex-type 3

2

2

High-throughput

0.628

High

568193

PLSL
Plastin-2

1

1

High-throughput

0.618

High

1491838

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.618

High

958545

ACTZ
Alpha-centractin

2

4

High-throughput

0.611

High

1110776

DCTN2
Dynactin subunit 2

2

1

High-throughput

0.611

High

1114787

CUL3
Cullin-3

2

2

High-throughput

0.611

High

1291615

HOOK3
Protein Hook homolog 3

2

3

High-throughput

0.611

High

1049076

REL
Proto-oncogene c-Rel

2

0

High-throughput

0.601

High

1350519

BICD2
Protein bicaudal D homolog 2

2

3

Small-scale

0.584

High

582128

PGAM2
Phosphoglycerate mutase 2

2

0

High-throughput

0.580

High

935372

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

904426

BRCA2
Breast cancer type 2 susceptibility protein

1

1

Small-scale

0.561

High

1403389

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.561

High

1491839

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.561

High

1393349

DOCK6
Dedicator of cytokinesis protein 6

2

0

High-throughput

0.547

High

270997

CLAP2
CLIP-associating protein 2

1

1

High-throughput

0.536

High

281466

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.536

High

721091

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.536

High

730402

1433B
14-3-3 protein beta/alpha

1

2

High-throughput

0.536

High

837270

ACTY
Beta-centractin

1

4

High-throughput

0.536

High

867565

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

953219

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

990927

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.536

High

993407

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.536

High

997583

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.536

High

1038490

TIE2
Angiopoietin-1 receptor

1

2

High-throughput

0.536

High

1152318

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

1278235

CLAP1
CLIP-associating protein 1

1

1

High-throughput

0.536

High

1404556

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1452956

ARP10
Actin-related protein 10

1

2

High-throughput

0.536

High

1491319

C2CD2
C2 domain-containing protein 2

1

1

High-throughput

0.536

High

373647

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.521

High

179421

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.513

High

298250

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

391682

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

866890

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

972188

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

1142237

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.513

High

1413459

DCTN5
Dynactin subunit 5

1

0

High-throughput

0.513

High

1417707

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

1459116

CCD39
Coiled-coil domain-containing protein 39

1

0

High-throughput

0.513

High

1460703

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.513

High

1491819

NFS1
Cysteine desulfurase

1

0

High-throughput

0.513

High

186153

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

1381256

WBP2
WW domain-binding protein 2

1

0

High-throughput

0.493

High

484700

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1371220

GLMN
Glomulin

1

1

High-throughput

0.489

High

631051

RAB4A
Ras-related protein Rab-4A

1

3

Small-scale

0.481

High

133701

WASL
Actin nucleation-promoting factor WASL

1

2

High-throughput

0.479

High

215962

SYNJ1
Synaptojanin-1

1

2

High-throughput

0.479

High

251832

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

3

High-throughput

0.479

High

273735

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

3

High-throughput

0.479

High

340274

PCNT
Pericentrin

1

2

Small-scale

0.479

High

412906

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

456900

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

583047

EZRI
Ezrin

1

1

High-throughput

0.479

High

610074

VGFR1
Vascular endothelial growth factor receptor 1

1

3

High-throughput

0.479

High

650518

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.479

High

658628

KS6B1
Ribosomal protein S6 kinase beta-1

1

1

High-throughput

0.479

High

720377

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.479

High

731749

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

777810

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.479

High

787114

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.479

High

791882

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

905353

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

920726

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.479

High

967623

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

971379

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

976706

RB11A
Ras-related protein Rab-11A

1

2

Small-scale

0.479

High

986844

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1034092

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

2

High-throughput

0.479

High

1052132

CALD1
Caldesmon

1

2

High-throughput

0.479

High

1092955

STRN3
Striatin-3

1

4

High-throughput

0.479

High

1108334

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1132476

CASP8
Caspase-8

1

1

High-throughput

0.479

High

1147322

ELOB
Elongin-B

1

1

High-throughput

0.479

High

1156442

SEPT7
Septin-7

1

2

High-throughput

0.479

High

1278167

MAVS
Mitochondrial antiviral-signaling protein

1

4

High-throughput

0.479

High

1289112

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.479

High

1326402

NIN
Ninein

1

3

High-throughput

0.479

High

1349717

CIP2A
Protein CIP2A

1

2

High-throughput

0.479

High

1364753

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1391223

BICD1
Protein bicaudal D homolog 1

1

2

High-throughput

0.479

High

1416519

SRBS1
Sorbin and SH3 domain-containing protein 1

1

2

High-throughput

0.479

High

1419941

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.479

High

1430499

RAB1B
Ras-related protein Rab-1B

1

2

High-throughput

0.479

High

1434372

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1438280

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.479

High

1453077

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1459872

SEPT9
Septin-9

1

2

High-throughput

0.479

High

1460063

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

1

High-throughput

0.479

High

1460593

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.479

High

1460656

DBNL
Drebrin-like protein

1

3

High-throughput

0.479

High

141193

NOP56
Nucleolar protein 56

1

0

High-throughput

0.460

High

161680

TRDMT
tRNA

1

0

High-throughput

0.458

High

224841

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.458

High

317267

AL1A2
Retinal dehydrogenase 2

1

0

High-throughput

0.458

High

338387

SC24A
Protein transport protein Sec24A

1

0

High-throughput

0.458

High

346574

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

364102

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

459825

PROF1
Profilin-1

1

0

High-throughput

0.458

High

567531

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

766990

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

800602

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.458

High

878590

PAXI
Paxillin

1

0

High-throughput

0.458

High

883382

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

955805

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.458

High

997218

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.458

High

1033834

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1095236

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

0

High-throughput

0.458

High

1099836

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

1107390

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1199776

KLH22
Kelch-like protein 22

1

0

High-throughput

0.458

High

1204233

PDZ11
PDZ domain-containing protein 11

1

0

High-throughput

0.458

High

1239799

FAP20
Fanconi anemia core complex-associated protein 20

1

0

High-throughput

0.458

High

1249382

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1280650

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1335125

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1339784

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1351907

PK1L1
Polycystin-1-like protein 1

1

0

High-throughput

0.458

High

1366055

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

0

High-throughput

0.458

High

1380703

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1390434

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1394539

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.458

High

1397616

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1398427

CEP63
Centrosomal protein of 63 kDa

1

0

Small-scale

0.458

High

1400895

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.458

High

1412746

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1435522

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1439349

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

1447204

AVEN
Cell death regulator Aven

1

0

High-throughput

0.458

High

1448094

SPHK2
Sphingosine kinase 2

1

0

Small-scale

0.458

High

1449140

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1451774

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1459499

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1490542

NUDC
Nuclear migration protein nudC

1

0

Small-scale

0.458

High

1491270

GRIP1
Glutamate receptor-interacting protein 1

1

0

High-throughput

0.458

High

1491761

SNX9
Sorting nexin-9

1

0

High-throughput

0.458

High

564629

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

844907

EAA1
Excitatory amino acid transporter 1

1

2

High-throughput

0.445

High

845170

EAA3
Excitatory amino acid transporter 3

1

2

High-throughput

0.445

High

952397

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.445

High

1428447

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.445

High

106939

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

590165

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

607284

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

769650

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1256313

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1367712

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

839121

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

1119409

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1209859

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1226344

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.426

High

1462631

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

887392

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

1287494

TRPT1
tRNA 2'-phosphotransferase 1

2

0

High-throughput

0.328

High

1350932

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

325198

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

405218

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.249

Low

419294

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.249

Low

1201973

BRDT
Bromodomain testis-specific protein

1

0

High-throughput

0.249

Low

1225991

F91A1
Protein FAM91A1

1

0

High-throughput

0.249

Low

1250703

BCOR
BCL-6 corepressor

1

0

High-throughput

0.249

Low

1277055

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1288862

GTD2A
General transcription factor II-I repeat domain-containing protein 2A

1

0

High-throughput

0.249

Low

1327757

MACOI
Macoilin

1

0

High-throughput

0.249

Low

1412910

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.249

Low

1428286

ADSSP
Adipose-secreted signaling protein

1

0

High-throughput

0.249

Low

1429423

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1438677

CBX8
Chromobox protein homolog 8

1

0

High-throughput

0.249

Low

1451095

BSDC1
BSD domain-containing protein 1

1

0

High-throughput

0.249

Low

1451523

CZIB
CXXC motif containing zinc binding protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025