Protein: NIF3L
NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein)

Gene: NIF3L, NIF3L1
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q9GZT8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0030182 - neuron differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1428846

NIF3L
NIF3-like protein 1

5

4

Small-scale

0.920

High

572198

TRI27
Zinc finger protein RFP

4

1

High-throughput

0.688

High

1128186

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

4

0

High-throughput

0.679

High

794618

RBMX
RNA-binding motif protein, X chromosome

3

1

High-throughput

0.667

High

842992

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

2

High-throughput

0.654

High

1228716

C102B
Coiled-coil domain-containing protein 102B

3

0

High-throughput

0.646

High

1336001

SMIP6
Sperm microtubule inner protein 6

3

0

High-throughput

0.638

High

1023285

RBM3
RNA-binding protein 3

2

2

High-throughput

0.628

High

881806

DHYS
Deoxyhypusine synthase

2

0

High-throughput

0.613

High

1151069

PCH2
Pachytene checkpoint protein 2 homolog

2

0

High-throughput

0.613

High

180387

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.606

High

216285

PPIH
Peptidyl-prolyl cis-trans isomerase H

2

1

High-throughput

0.606

High

807575

IF4A3
Eukaryotic initiation factor 4A-III

2

1

High-throughput

0.606

High

937502

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

2

High-throughput

0.606

High

1055551

ST2A1
Sulfotransferase 2A1

2

2

High-throughput

0.606

High

1347382

LMO3
LIM domain only protein 3

2

1

High-throughput

0.606

High

1398288

KCTD7
BTB/POZ domain-containing protein KCTD7

2

2

High-throughput

0.606

High

1428869

NDK7
Nucleoside diphosphate kinase homolog 7

2

1

High-throughput

0.606

High

1134801

ODFP1
Outer dense fiber protein 1

2

0

High-throughput

0.602

High

1272094

MIGA2
Mitoguardin 2

2

0

High-throughput

0.602

High

1397917

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

0

High-throughput

0.598

High

893737

MEOX1
Homeobox protein MOX-1

2

0

High-throughput

0.585

High

1331405

PLPL1
Omega-hydroxyceramide transacylase

2

0

High-throughput

0.585

High

528345

THIO
Thioredoxin

2

0

High-throughput

0.580

High

936928

CASP7
Caspase-7

2

0

High-throughput

0.580

High

940464

TCL1A
T-cell leukemia/lymphoma protein 1A

2

0

High-throughput

0.580

High

1142461

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

2

0

High-throughput

0.580

High

1144587

PTPA
Serine/threonine-protein phosphatase 2A activator

2

0

High-throughput

0.580

High

1229399

DUS29
Dual specificity phosphatase 29

2

0

High-throughput

0.580

High

1289300

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1338806

FAD1
FAD synthase

2

0

High-throughput

0.580

High

1399531

IP6K3
Inositol hexakisphosphate kinase 3

2

0

High-throughput

0.580

High

1428850

NEK6
Serine/threonine-protein kinase Nek6

2

0

High-throughput

0.580

High

1428857

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.580

High

1428859

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

2

0

High-throughput

0.580

High

1428861

KCIP1
A-type potassium channel modulatory protein KCNIP1

2

0

High-throughput

0.580

High

377044

NEU2
Vasopressin-neurophysin 2-copeptin

2

1

High-throughput

0.574

High

516067

ST1A4
Sulfotransferase 1A4

1

2

High-throughput

0.573

High

681920

RBTN2
Rhombotin-2

1

1

High-throughput

0.573

High

842932

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

2

High-throughput

0.573

High

894297

ST1A2
Sulfotransferase 1A2

1

2

High-throughput

0.573

High

987926

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.573

High

584803

NDKA
Nucleoside diphosphate kinase A

1

1

High-throughput

0.560

High

479193

HBAT
Hemoglobin subunit theta-1

2

1

High-throughput

0.558

High

1271405

KCTD9
BTB/POZ domain-containing protein KCTD9

2

2

High-throughput

0.553

High

958711

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.549

High

291863

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.549

High

900501

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.549

High

907979

DYLT3
Dynein light chain Tctex-type 3

1

0

High-throughput

0.549

High

1415380

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.549

High

1428847

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.549

High

1428856

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.549

High

1428863

DCDC2
Doublecortin domain-containing protein 2

1

0

High-throughput

0.549

High

623527

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.541

High

1090905

TRAF2
TNF receptor-associated factor 2

1

1

High-throughput

0.541

High

1328668

KCD17
BTB/POZ domain-containing protein KCTD17

1

2

High-throughput

0.541

High

646934

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.536

High

1392538

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.536

High

228363

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.518

High

262162

NOL3
Nucleolar protein 3

1

0

High-throughput

0.518

High

354251

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

High-throughput

0.518

High

474970

VIME
Vimentin

1

0

High-throughput

0.518

High

618106

K1C15
Keratin, type I cytoskeletal 15

1

0

High-throughput

0.518

High

657044

S10A1
Protein S100-A1

1

0

High-throughput

0.518

High

733882

DCTD
Deoxycytidylate deaminase

1

0

High-throughput

0.518

High

800091

COIL
Coilin

1

0

High-throughput

0.518

High

848937

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.518

High

880469

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.518

High

1150079

MARE2
Microtubule-associated protein RP/EB family member 2

1

0

High-throughput

0.518

High

1154587

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1385950

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

0

High-throughput

0.518

High

1392618

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.518

High

1428849

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.518

High

1428866

T22D4
TSC22 domain family protein 4

1

0

High-throughput

0.518

High

258614

SH21A
SH2 domain-containing protein 1A

1

2

High-throughput

0.515

High

462163

GALT
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.513

High

1277398

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.513

High

1357068

FBLI1
Filamin-binding LIM protein 1

1

0

High-throughput

0.513

High

1369378

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

High-throughput

0.513

High

1413539

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.513

High

1203610

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.493

High

377019

NEU1
Oxytocin-neurophysin 1

1

1

High-throughput

0.489

High

660722

IF4B
Eukaryotic translation initiation factor 4B

1

1

High-throughput

0.489

High

1186980

KR151
Keratin-associated protein 15-1

1

1

High-throughput

0.489

High

1198048

KR132
Keratin-associated protein 13-2

1

1

High-throughput

0.489

High

1336467

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.486

High

1428865

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.486

High

230919

ORC5
Origin recognition complex subunit 5

1

1

High-throughput

0.481

High

1255453

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

326188

FSBP
Fibrinogen silencer-binding protein

1

0

High-throughput

0.473

High

61819

A4D0P7
Origin recognition complex subunit 5

1

1

High-throughput

0.470

High

827919

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.460

High

1233214

THOC7
THO complex subunit 7

1

0

Small-scale

0.460

High

1428854

CUTC
Copper homeostasis protein cutC homolog

1

0

High-throughput

0.460

High

1428871

RA54B
DNA repair and recombination protein RAD54B

1

0

High-throughput

0.460

High

691411

1433T
14-3-3 protein theta

1

0

Small-scale

0.458

High

777009

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.458

High

1108129

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1135609

UBX2B
UBX domain-containing protein 2B

1

0

High-throughput

0.458

High

1428868

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1428855

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

303190

RGS20
Regulator of G-protein signaling 20

1

0

High-throughput

0.438

High

1428858

ZN446
Zinc finger protein 446

1

0

High-throughput

0.438

High

404904

PRIO
Major prion protein

1

0

High-throughput

0.426

High

485401

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.426

High

1130444

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1335316

FA98A
Protein FAM98A

1

0

High-throughput

0.426

High

1428851

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.426

High

330307

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

349345

NUD14
Uridine diphosphate glucose pyrophosphatase NUDT14

3

0

High-throughput

0.352

High

1329588

NATD1
Protein NATD1

3

0

High-throughput

0.352

High

639645

SAT1
Diamine acetyltransferase 1

3

0

High-throughput

0.350

High

1410904

GORS1
Golgi reassembly-stacking protein 1

3

0

High-throughput

0.345

High

1330682

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.334

High

1428864

PRAF1
Prenylated Rab acceptor protein 1

2

0

High-throughput

0.334

High

336602

PPN
Papilin

2

0

High-throughput

0.328

High

1241239

CA094
Uncharacterized protein C1orf94

2

0

High-throughput

0.328

High

1351364

SACA4
Sperm acrosome membrane-associated protein 4

2

0

High-throughput

0.318

High

1361606

SEPT1
Septin-1

2

0

High-throughput

0.316

High

1428852

NGB
Neuroglobin

2

0

High-throughput

0.316

High

1428860

SPG21
Maspardin

2

0

High-throughput

0.316

High

181821

EPHB6
Ephrin type-B receptor 6

1

0

High-throughput

0.299

High

463217

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.299

High

1180657

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.299

High

1280153

ARPIN
Arpin

1

0

High-throughput

0.299

High

1412939

SYT17
Synaptotagmin-17

1

0

High-throughput

0.299

High

1428862

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.299

High

719512

BKRB2
B2 bradykinin receptor

1

0

High-throughput

0.282

High

961636

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.282

High

1131932

GNMT
Glycine N-methyltransferase

1

0

High-throughput

0.282

High

1349503

ENOX1
Ecto-NOX disulfide-thiol exchanger 1

1

0

High-throughput

0.282

High

1410520

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.282

High

1428853

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

0

High-throughput

0.282

High

647473

UD14
UDP-glucuronosyltransferase 1A4

1

0

High-throughput

0.279

Low

1186601

KRA61
Keratin-associated protein 6-1

1

0

High-throughput

0.279

Low

1213608

QNG1
Queuosine 5'-phosphate N-glycosylase/hydrolase

1

0

High-throughput

0.279

Low

1428867

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

1428870

TNR18
Tumor necrosis factor receptor superfamily member 18

1

0

High-throughput

0.279

Low

106620

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

769122

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1356072

DDI1
Protein DDI1 homolog 1

1

0

High-throughput

0.238

Low

142410

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.232

Low

1329984

CJ053
UPF0728 protein C10orf53

1

0

High-throughput

0.232

Low

1392988

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.232

Low

1428848

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025