Protein: TMM25
Transmembrane protein 25

Gene: TMM25, TMEM25
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q86YD3

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005764 - lysosome
GO:0005770 - late endosome
GO:0005886 - plasma membrane
GO:0031647 - regulation of protein stability

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295027

SEM3C
Semaphorin-3C

1

2

High-throughput

0.691

High

1295019

HTRA1
Serine protease HTRA1

4

1

High-throughput

0.691

High

215722

COCH
Cochlin

3

2

High-throughput

0.667

High

337534

LARG1
Xylosyl- and glucuronyltransferase LARGE1

3

1

High-throughput

0.667

High

582347

ARSA
Arylsulfatase A

3

2

High-throughput

0.667

High

618195

AMD
Peptidyl-glycine alpha-amidating monooxygenase

3

1

High-throughput

0.667

High

709068

PCSK6
Proprotein convertase subtilisin/kexin type 6

3

2

High-throughput

0.667

High

937410

LAMB2
Laminin subunit beta-2

3

2

High-throughput

0.667

High

997016

TBA4A
Tubulin alpha-4A chain

3

2

High-throughput

0.667

High

1013370

HTRA3
Serine protease HTRA3

3

1

High-throughput

0.667

High

1248910

ARSK
Arylsulfatase K

3

2

High-throughput

0.667

High

366550

TPA
Tissue-type plasminogen activator

3

0

High-throughput

0.638

High

1105749

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

3

0

High-throughput

0.638

High

1120544

NID2
Nidogen-2

3

0

High-throughput

0.638

High

1175810

T132A
Transmembrane protein 132A

3

0

High-throughput

0.638

High

1194499

ERFE
Erythroferrone

3

0

High-throughput

0.638

High

1212668

GT253
Inactive glycosyltransferase 25 family member 3

3

0

High-throughput

0.638

High

1295042

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

3

0

High-throughput

0.638

High

448047

ITAV
Integrin alpha-V

2

2

High-throughput

0.628

High

922828

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

2

2

High-throughput

0.628

High

183274

LAMA5
Laminin subunit alpha-5

2

3

High-throughput

0.611

High

343856

SEM4F
Semaphorin-4F

2

2

High-throughput

0.611

High

1272613

PCAT2
Lysophosphatidylcholine acyltransferase 2

2

2

High-throughput

0.611

High

1295044

PLXA1
Plexin-A1

2

2

High-throughput

0.611

High

335392

GDF11
Growth/differentiation factor 11

3

1

High-throughput

0.609

High

1112249

PEX6
Peroxisomal ATPase PEX6

3

2

High-throughput

0.609

High

1191868

TBB8
Tubulin beta-8 chain

3

2

High-throughput

0.609

High

1225720

LPCT4
Lysophospholipid acyltransferase LPCAT4

3

2

High-throughput

0.609

High

1243274

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

3

1

High-throughput

0.609

High

1295012

PGLT1
Protein O-glucosyltransferase 1

3

2

High-throughput

0.609

High

1295031

AFG2B
ATPase family gene 2 protein homolog B

3

2

High-throughput

0.609

High

1295030

FUZZY
Protein fuzzy homolog

3

1

High-throughput

0.599

High

363523

EGFR
Epidermal growth factor receptor

2

0

High-throughput

0.585

High

467837

BGLR
Beta-glucuronidase

2

0

High-throughput

0.585

High

535264

BIP
Endoplasmic reticulum chaperone BiP

2

0

High-throughput

0.585

High

787828

PEDF
Pigment epithelium-derived factor

2

0

High-throughput

0.585

High

1295032

CHID1
Chitinase domain-containing protein 1

2

0

High-throughput

0.585

High

1295035

EHD1
EH domain-containing protein 1

2

0

High-throughput

0.585

High

1295025

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.578

High

1108593

TBB3
Tubulin beta-3 chain

2

2

High-throughput

0.574

High

1295009

LARG2
Xylosyl- and glucuronyltransferase LARGE2

2

1

High-throughput

0.558

High

921549

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

0

High-throughput

0.549

High

376865

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.536

High

457534

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

675073

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.536

High

1030420

DIAC
Di-N-acetylchitobiase

1

1

High-throughput

0.536

High

1098321

SEM3B
Semaphorin-3B

1

2

High-throughput

0.536

High

1116725

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

2

High-throughput

0.536

High

282846

CRLF1
Cytokine receptor-like factor 1

1

0

High-throughput

0.513

High

350718

NOE2
Noelin-2

1

0

High-throughput

0.513

High

697941

CALR
Calreticulin

1

0

High-throughput

0.513

High

1084049

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

0

High-throughput

0.513

High

1089113

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1143738

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.513

High

1295016

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.513

High

1295029

S39A3
Zinc transporter ZIP3

1

0

High-throughput

0.513

High

1295049

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.513

High

1295051

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

882761

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.489

High

1043148

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.489

High

1043220

TAP2
Antigen peptide transporter 2

1

1

High-throughput

0.489

High

1143633

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.489

High

1244952

FIGL1
Fidgetin-like protein 1

1

3

High-throughput

0.489

High

1248331

PLGT2
Protein O-glucosyltransferase 2

1

2

High-throughput

0.489

High

1278465

PLGT3
Protein O-glucosyltransferase 3

1

2

High-throughput

0.489

High

1295011

AFG2A
ATPase family gene 2 protein homolog A

1

2

High-throughput

0.489

High

1295015

FBX27
F-box only protein 27

1

1

High-throughput

0.489

High

1295026

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

1295043

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.489

High

1295046

FBX2
F-box only protein 2

1

1

High-throughput

0.489

High

462896

LAMB1
Laminin subunit beta-1

1

2

High-throughput

0.479

High

471598

CO4A2

1

1

High-throughput

0.479

High

810617

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

2

High-throughput

0.479

High

907217

SPHM
N-sulphoglucosamine sulphohydrolase

1

2

High-throughput

0.479

High

1052159

COEA1
Collagen alpha-1(XIV) chain

1

2

High-throughput

0.479

High

1259320

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.479

High

277022

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.458

High

846821

BTD
Biotinidase

1

0

High-throughput

0.458

High

782927

CH3L1
Chitinase-3-like protein 1

1

1

High-throughput

0.445

High

1295014

COMA1

1

2

High-throughput

0.445

High

999538

NOMO3
BOS complex subunit NOMO3

1

1

High-throughput

0.437

High

1248270

MOXD1
DBH-like monooxygenase protein 1

1

1

High-throughput

0.437

High

1251320

B3GLT
Beta-1,3-glucosyltransferase

1

1

High-throughput

0.437

High

1295007

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

1

High-throughput

0.437

High

1295020

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

1

1

High-throughput

0.437

High

501833

CO4A
Complement C4-A

1

0

High-throughput

0.426

High

963962

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.426

High

1126027

GAS6
Growth arrest-specific protein 6

1

0

High-throughput

0.426

High

1295005

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.426

High

1295013

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.426

High

97007

E9PK12
Fuzzy planar cell polarity protein

1

1

High-throughput

0.407

High

1295022

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

4

0

High-throughput

0.360

High

849470

NAMPT
Nicotinamide phosphoribosyltransferase

3

0

High-throughput

0.347

High

885485

MA2A2
Alpha-mannosidase 2x

3

0

High-throughput

0.347

High

1051792

EF1A2
Elongation factor 1-alpha 2

3

0

High-throughput

0.347

High

1067023

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

3

0

High-throughput

0.347

High

1160412

TAZ
Tafazzin

3

0

High-throughput

0.347

High

1179104

TECT1
Tectonic-1

3

0

High-throughput

0.347

High

1193199

OFUT4
GDP-fucose protein O-fucosyltransferase 4

3

0

High-throughput

0.347

High

1248896

EST3
Carboxylesterase 3

3

0

High-throughput

0.347

High

1293606

DYR2
Dihydrofolate reductase 2, mitochondrial

3

0

High-throughput

0.347

High

1295006

P3H3
Prolyl 3-hydroxylase 3

3

0

High-throughput

0.347

High

1295018

DC2I1
Cytoplasmic dynein 2 intermediate chain 1

3

0

High-throughput

0.347

High

1295021

BSCL2
Seipin

3

0

High-throughput

0.347

High

1295023

LMLN
Leishmanolysin-like peptidase

3

0

High-throughput

0.347

High

1295038

DEFM
Peptide deformylase, mitochondrial

3

0

High-throughput

0.347

High

1295039

ZN302
Zinc finger protein 302

3

0

High-throughput

0.347

High

1295040

SYIM
Isoleucine--tRNA ligase, mitochondrial

3

0

High-throughput

0.347

High

300183

GLRX3
Glutaredoxin-3

2

0

High-throughput

0.337

High

143868

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.328

High

219816

CHSTA
Carbohydrate sulfotransferase 10

2

0

High-throughput

0.328

High

981881

RL23
Large ribosomal subunit protein uL14

2

0

High-throughput

0.318

High

1295010

BANP
Protein BANP

2

0

High-throughput

0.318

High

1295052

LOXL2
Lysyl oxidase homolog 2

2

0

High-throughput

0.318

High

554811

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

2

0

High-throughput

0.313

High

1295034

SIL1
Nucleotide exchange factor SIL1

2

0

High-throughput

0.313

High

1187790

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

2

0

High-throughput

0.298

High

191919

MAGB4
Melanoma-associated antigen B4

1

0

High-throughput

0.279

Low

287710

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.279

Low

483598

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

539076

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.279

Low

547164

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.279

Low

771670

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

903618

GALK1
Galactokinase

1

0

High-throughput

0.279

Low

908762

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.279

Low

1180369

HKDC1
Hexokinase HKDC1

1

0

High-throughput

0.279

Low

1204574

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

0

High-throughput

0.279

Low

1225402

METRL
Meteorin-like protein

1

0

High-throughput

0.279

Low

1235407

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1295008

TRM2A
tRNA

1

0

High-throughput

0.279

Low

1295028

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1295033

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.279

Low

1295036

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1295041

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

0

High-throughput

0.279

Low

1295048

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.279

Low

505580

ATX1L
Ataxin-1-like

1

0

High-throughput

0.251

Low

551141

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

1036889

SP3
Transcription factor Sp3

1

0

High-throughput

0.249

Low

1295045

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

0

High-throughput

0.249

Low

1295050

TPRKB
EKC/KEOPS complex subunit TPRKB

1

0

High-throughput

0.249

Low

332319

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.232

Low

341980

CEP43
Centrosomal protein 43

1

0

High-throughput

0.232

Low

460919

LDHC
L-lactate dehydrogenase C chain

1

0

High-throughput

0.232

Low

771903

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.232

Low

1295017

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.232

Low

1295024

CNT3B
Contactin-associated protein-like 3B

1

0

High-throughput

0.232

Low

1295037

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.232

Low

1295047

ANGL2
Angiopoietin-related protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025