Protein: OGA
Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)

Gene: OGA
Organism: Homo sapiens
Interactions: 98
UniProt ID: O60502

Gene Ontology (top 5):
GO:0004415 - hyalurononglucosaminidase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006044 - N-acetylglucosamine metabolic process
GO:0006493 - protein O-linked glycosylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

185279

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

3

0

Small-scale

0.828

High

249938

OGA
Protein O-GlcNAcase

2

1

Small-scale

0.768

High

250014

STN1
CST complex subunit STN1

3

0

High-throughput

0.638

High

249963

FMO5
Flavin-containing monooxygenase 5

2

0

High-throughput

0.602

High

249967

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

2

0

High-throughput

0.602

High

249978

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

249947

P53
Cellular tumor antigen p53

2

0

Small-scale

0.569

High

249945

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

249954

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.547

High

249977

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.518

High

250011

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

249948

ISG15
Ubiquitin-like protein ISG15

1

0

High-throughput

0.513

High

249964

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.513

High

250015

CBX8
Chromobox protein homolog 8

1

0

High-throughput

0.513

High

250016

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.513

High

250022

S30BP
SAP30-binding protein

1

0

High-throughput

0.513

High

155054

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.493

High

249966

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

249971

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

250023

XPO7
Exportin-7

1

1

High-throughput

0.479

High

249965

PSN2
Presenilin-2

1

0

High-throughput

0.460

High

240225

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

249943

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

249957

EZRI
Ezrin

1

0

High-throughput

0.458

High

249958

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

249960

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

249962

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

249970

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

249972

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

249974

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

249975

IRF5
Interferon regulatory factor 5

1

0

Small-scale

0.458

High

249976

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

249979

FBX43
F-box only protein 43

1

0

Small-scale

0.458

High

249986

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

249989

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.458

High

249990

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

249991

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

249996

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

249999

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

250003

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

250004

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

250008

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

250019

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

250020

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

250021

TES
Testin

1

0

High-throughput

0.458

High

250026

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

250000

SPSB4
SPRY domain-containing SOCS box protein 4

1

1

High-throughput

0.445

High

249968

HAP1
Huntingtin-associated protein 1

1

0

High-throughput

0.438

High

250005

SPAG5
Sperm-associated antigen 5

1

0

High-throughput

0.438

High

249988

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

142247

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

231538

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

249939

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.426

High

249949

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

249950

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.426

High

249953

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

249955

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.426

High

249969

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

249973

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.426

High

249982

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

249983

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

249993

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

249998

I22R2
Interleukin-22 receptor subunit alpha-2

1

0

High-throughput

0.426

High

250002

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

250007

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.426

High

250013

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

250027

ASB4
Ankyrin repeat and SOCS box protein 4

1

0

High-throughput

0.426

High

250028

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.426

High

249959

KLK2
Kallikrein-2

1

1

High-throughput

0.407

High

249994

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.407

High

249951

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

0

High-throughput

0.347

High

249984

PPR18
Phostensin

3

0

High-throughput

0.347

High

249980

LACB2
Endoribonuclease LACTB2

3

0

High-throughput

0.342

High

250025

EMC9
ER membrane protein complex subunit 9

2

0

High-throughput

0.328

High

249944

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.282

High

250024

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.282

High

249942

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.279

Low

249956

ACYP2
Acylphosphatase-2

1

0

High-throughput

0.279

Low

249985

S2547
Solute carrier family 25 member 47

1

0

High-throughput

0.279

Low

250006

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

104919

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

249946

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

249952

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

249961

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

249987

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

249992

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.249

Low

250001

Q96BE0
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

250009

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.249

Low

250010

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.249

Low

250018

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

Small-scale

0.249

Low

249940

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

249941

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

249981

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low

249995

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

0

High-throughput

0.232

Low

249997

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

250012

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low

250017

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025