Protein: TPP1
Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I)

Gene: TPP1
Organism: Homo sapiens
Interactions: 81
UniProt ID: O14773

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005764 - lysosome
GO:0005794 - Golgi apparatus
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163570

RPTOR
Regulatory-associated protein of mTOR

2

1

High-throughput

0.628

High

162880

TERT
Telomerase reverse transcriptase

2

0

Small-scale

0.619

High

143767

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.602

High

163582

OMA1
Metalloendopeptidase OMA1, mitochondrial

2

0

High-throughput

0.602

High

163537

GDC
Solute carrier family 25 member 16

2

1

High-throughput

0.574

High

163532

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

163596

POTE1
Protection of telomeres protein 1

2

1

Small-scale

0.570

High

163527

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

163586

TINF2
TERF1-interacting nuclear factor 2

1

0

Small-scale

0.537

High

163599

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

1

High-throughput

0.536

High

163567

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.517

High

163547

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

1

High-throughput

0.515

High

163540

CALX
Calnexin

1

0

High-throughput

0.513

High

163560

GRDN
Girdin

1

0

High-throughput

0.513

High

163566

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.513

High

163568

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

131574

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.493

High

163583

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

163529

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

163530

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

163535

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

163543

BASI
Basigin

1

0

High-throughput

0.458

High

163556

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

163557

CUL7
Cullin-7

1

0

High-throughput

0.458

High

163569

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

163576

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

163578

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

163585

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

163589

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

163594

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

163597

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.458

High

163573

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

1

High-throughput

0.445

High

163542

C2TA
MHC class II transactivator

1

1

Small-scale

0.437

High

163577

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

163533

ANGI
Angiogenin

1

0

High-throughput

0.426

High

163534

PRIO
Major prion protein

1

0

High-throughput

0.426

High

163536

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

163546

HD
Huntingtin

1

0

High-throughput

0.426

High

163555

TAGL
Transgelin

1

0

High-throughput

0.426

High

163526

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.407

High

163551

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

1

High-throughput

0.407

High

163574

CTR3
Cationic amino acid transporter 3

1

1

High-throughput

0.407

High

163559

CTC1
CST complex subunit CTC1

2

0

Small-scale

0.335

High

163591

STN1
CST complex subunit STN1

2

0

Small-scale

0.335

High

163558

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

0

High-throughput

0.318

High

104837

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

163531

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

163538

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

163584

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

163528

TSN2
Tetraspanin-2

1

0

High-throughput

0.279

Low

163548

DGKG
Diacylglycerol kinase gamma

1

0

High-throughput

0.279

Low

163562

KMCP1
Kidney mitochondrial carrier protein 1

1

0

High-throughput

0.279

Low

163575

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

0

High-throughput

0.279

Low

163579

POP5
Ribonuclease P/MRP protein subunit POP5

1

0

High-throughput

0.279

Low

163580

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

163588

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

163561

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.268

Low

163565

FBX42
F-box only protein 42

1

0

High-throughput

0.268

Low

163571

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

High-throughput

0.268

Low

163581

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

163587

TRAF4
TNF receptor-associated factor 4

1

0

High-throughput

0.268

Low

163595

CISH
Cytokine-inducible SH2-containing protein

1

0

High-throughput

0.268

Low

163598

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.268

Low

163601

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.268

Low

163525

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

163541

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.249

Low

163544

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.249

Low

163545

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

163549

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

163553

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

163554

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

163572

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

163590

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.249

Low

163592

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

163593

MAGF1
Melanoma-associated antigen F1

1

0

Small-scale

0.249

Low

163600

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

163552

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

163539

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

163550

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.232

Low

163563

S35F1
Solute carrier family 35 member F1

1

0

High-throughput

0.232

Low

163564

ZN746
Zinc finger protein 746

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025