Protein: SYLM
Leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)

Gene: SYLM, LARS2
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q15031

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

774362

BASI
Basigin

3

1

High-throughput

0.667

High

275292

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

2

High-throughput

0.628

High

349673

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

1

High-throughput

0.628

High

842206

THIM
3-ketoacyl-CoA thiolase, mitochondrial

2

1

High-throughput

0.628

High

946488

YBEY
Endoribonuclease YbeY

2

1

High-throughput

0.628

High

1138845

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

1

High-throughput

0.628

High

1138852

RM21
Large ribosomal subunit protein bL21m

2

1

High-throughput

0.628

High

1138843

MRM1
rRNA methyltransferase 1, mitochondrial

2

2

High-throughput

0.611

High

1138888

MTG2
Mitochondrial ribosome-associated GTPase 2

2

6

High-throughput

0.611

High

716680

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

2

0

High-throughput

0.602

High

921428

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

2

0

High-throughput

0.602

High

1138854

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

241718

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

279762

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

1138838

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

1138894

DUS22
Dual specificity protein phosphatase 22

2

2

High-throughput

0.574

High

218197

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.558

High

767437

RADI
Radixin

2

1

High-throughput

0.549

High

642095

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

1

High-throughput

0.536

High

690492

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.536

High

869160

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

1138855

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1138858

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

1

High-throughput

0.536

High

1138862

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

1

High-throughput

0.536

High

1138871

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1138873

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1138880

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

1138908

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

1138909

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1138913

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1138914

RT02
Small ribosomal subunit protein uS2m

1

4

High-throughput

0.536

High

1138839

HKDC1
Hexokinase HKDC1

1

1

High-throughput

0.515

High

271049

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

288233

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

0

High-throughput

0.513

High

289774

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

333659

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.513

High

425909

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

577971

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.513

High

641782

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

892571

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

1138837

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1138848

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1138856

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1138893

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

1138896

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1138901

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.513

High

1138902

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.513

High

1138905

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1138911

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

1138912

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.513

High

154824

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

1

High-throughput

0.489

High

182535

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

1138860

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

1

High-throughput

0.489

High

1138875

RSLAB
Ras-like protein family member 10B

1

1

High-throughput

0.489

High

1138877

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

1138878

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.489

High

1138892

B2L12
Bcl-2-like protein 12

1

1

High-throughput

0.489

High

1138916

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

1138918

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

61503

VWA8
von Willebrand factor A domain-containing protein 8

1

3

High-throughput

0.479

High

183650

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.479

High

281952

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

287293

RF1M
Peptide chain release factor 1, mitochondrial

1

9

High-throughput

0.479

High

350869

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

361633

OTC
Ornithine transcarbamylase, mitochondrial

1

4

High-throughput

0.479

High

411957

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

471030

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

519114

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

2

High-throughput

0.479

High

532594

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

559960

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

2

High-throughput

0.479

High

828777

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

841741

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

3

High-throughput

0.479

High

851892

EFTS
Elongation factor Ts, mitochondrial

1

2

High-throughput

0.479

High

856265

IF2M
Translation initiation factor IF-2, mitochondrial

1

11

High-throughput

0.479

High

882680

EFTU
Elongation factor Tu, mitochondrial

1

12

High-throughput

0.479

High

883251

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

1048515

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1058026

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1062816

QOR
Quinone oxidoreductase

1

5

High-throughput

0.479

High

1083611

MPPA
Mitochondrial-processing peptidase subunit alpha

1

5

High-throughput

0.479

High

1087389

GRSF1
G-rich sequence factor 1

1

4

High-throughput

0.479

High

1090400

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

1117733

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

1123290

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.479

High

1135883

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

High-throughput

0.479

High

1138834

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1138836

SURF1
Surfeit locus protein 1

1

2

High-throughput

0.479

High

1138840

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

1138846

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

5

High-throughput

0.479

High

1138847

CH082
UPF0598 protein C8orf82

1

2

High-throughput

0.479

High

1138851

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

1138863

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

8

High-throughput

0.479

High

1138864

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

1138865

MCUR1
Mitochondrial calcium uniporter regulator 1

1

5

High-throughput

0.479

High

1138867

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

5

High-throughput

0.479

High

1138869

RRFM
Ribosome-recycling factor, mitochondrial

1

2

High-throughput

0.479

High

1138870

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

1138874

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

1138876

IMP2L
Mitochondrial inner membrane protease subunit 2

1

4

High-throughput

0.479

High

1138879

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

1138881

TR61B
tRNA

1

2

High-throughput

0.479

High

1138882

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

1138883

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

1138884

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

5

High-throughput

0.479

High

1138886

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

1138887

MTRFR
Mitochondrial translation release factor in rescue

1

9

High-throughput

0.479

High

1138890

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

1138891

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1138897

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

4

High-throughput

0.479

High

1138898

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

1138899

RMND1
Required for meiotic nuclear division protein 1 homolog

1

2

High-throughput

0.479

High

1138903

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

1138906

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

9

High-throughput

0.479

High

1138915

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

691021

1433T
14-3-3 protein theta

1

4

High-throughput

0.457

High

1138850

RHOU
Rho-related GTP-binding protein RhoU

1

4

High-throughput

0.457

High

593112

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

High-throughput

0.445

High

1138841

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1138900

TRM1
tRNA

1

1

High-throughput

0.445

High

588734

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695498

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768232

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1015448

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.437

High

1138849

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1138868

OPTN
Optineurin

1

7

High-throughput

0.437

High

1138889

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1138907

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1138910

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.437

High

653324

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1138844

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.426

High

604667

UBF1
Nucleolar transcription factor 1

1

2

High-throughput

0.407

High

1121671

SAFB2
Scaffold attachment factor B2

1

2

High-throughput

0.407

High

1138833

EEA1
Early endosome antigen 1

1

3

High-throughput

0.407

High

1138835

SAFB1
Scaffold attachment factor B1

1

1

High-throughput

0.407

High

1138895

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.407

High

1138861

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.328

High

260756

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

1138842

SYT6
Synaptotagmin-6

1

0

High-throughput

0.279

Low

1138866

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

1138904

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1138917

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

462422

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.249

Low

1106543

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

1138857

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1138859

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1088846

TP53B
TP53-binding protein 1

1

0

High-throughput

0.232

Low

1138853

AMZ2
Archaemetzincin-2

1

0

High-throughput

0.232

Low

1138872

GNA1
Glucosamine 6-phosphate N-acetyltransferase

1

0

High-throughput

0.232

Low

1138885

RBM38
RNA-binding protein 38

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025