Protein: SYHM
Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)

Gene: SYHM, HARS2
Organism: Homo sapiens
Interactions: 158
UniProt ID: P49590

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004821 - histidine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551698

HARS1
Histidine--tRNA ligase, cytoplasmic

5

14

High-throughput

0.922

High

532449

CH60
60 kDa heat shock protein, mitochondrial

3

5

High-throughput

0.667

High

884723

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.656

High

275265

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

884731

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

2

High-throughput

0.628

High

884618

SYHM
Histidine--tRNA ligase, mitochondrial

1

14

Small-scale

0.618

High

884633

GRSF1
G-rich sequence factor 1

3

0

Small-scale

0.613

High

884638

ICT1
Large ribosomal subunit protein mL62

2

1

High-throughput

0.611

High

884706

MTG2
Mitochondrial ribosome-associated GTPase 2

2

2

High-throughput

0.611

High

884710

ANLN
Anillin

2

1

High-throughput

0.611

High

641757

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

884620

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

884621

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

884628

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

884660

RM21
Large ribosomal subunit protein bL21m

2

0

High-throughput

0.602

High

884719

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

0

High-throughput

0.602

High

884682

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

2

0

High-throughput

0.585

High

241077

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

884642

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

395693

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

170012

AURKA
Aurora kinase A

1

1

High-throughput

0.536

High

274503

DNJB6
DnaJ homolog subfamily B member 6

1

5

High-throughput

0.536

High

361615

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.536

High

842194

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.536

High

869142

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

884631

AKP13
A-kinase anchor protein 13

1

1

High-throughput

0.536

High

884634

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.536

High

884652

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

2

High-throughput

0.536

High

884653

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

884661

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

2

High-throughput

0.536

High

884665

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

884667

MYLK4
Myosin light chain kinase family member 4

1

4

High-throughput

0.536

High

884671

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

884674

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.536

High

884680

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

4

High-throughput

0.536

High

884714

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.536

High

884722

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

884728

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.536

High

884729

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.536

High

884630

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.518

High

248572

FADS1
Acyl-CoA

1

1

High-throughput

0.515

High

137676

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.513

High

611798

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

716659

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.513

High

884619

STA5B
Signal transducer and activator of transcription 5B

1

0

High-throughput

0.513

High

884635

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.513

High

884639

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.513

High

884641

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

884643

ACOT6
Acyl-coenzyme A thioesterase 6

1

0

High-throughput

0.513

High

884649

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

884664

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

884666

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

1

0

High-throughput

0.513

High

884672

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.513

High

884673

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

884685

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

884686

PDLI5
PDZ and LIM domain protein 5

1

0

High-throughput

0.513

High

884694

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

884695

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

884697

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.513

High

884698

NUDT9
ADP-ribose pyrophosphatase, mitochondrial

1

0

High-throughput

0.513

High

884699

PHF7
E3 ubiquitin-protein ligase PHF7

1

0

High-throughput

0.513

High

884712

F217B
Protein FAM217B

1

0

High-throughput

0.513

High

884717

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.513

High

884724

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.513

High

185519

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

445649

KCRM
Creatine kinase M-type

1

0

High-throughput

0.493

High

884689

DGAT2
Diacylglycerol O-acyltransferase 2

1

0

High-throughput

0.493

High

261126

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.489

High

699545

IL1R2
Interleukin-1 receptor type 2

1

2

High-throughput

0.489

High

884624

LMNB2
Lamin-B2

1

1

High-throughput

0.489

High

884629

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.489

High

884677

GPX8
Probable glutathione peroxidase 8

1

1

High-throughput

0.489

High

884709

MAGF1
Melanoma-associated antigen F1

1

2

High-throughput

0.489

High

884732

FADS3
Fatty acid desaturase 3

1

1

High-throughput

0.489

High

279699

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

287257

RF1M
Peptide chain release factor 1, mitochondrial

1

4

High-throughput

0.479

High

293371

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

400480

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

470924

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

774920

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

828707

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

841653

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

856219

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

882591

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

884622

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

884625

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

884627

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

884636

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

884640

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

884646

SYAM
Alanine--tRNA ligase, mitochondrial

1

7

High-throughput

0.479

High

884662

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

2

High-throughput

0.479

High

884681

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

884683

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

884691

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

884700

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

884705

MTRFR
Mitochondrial translation release factor in rescue

1

4

High-throughput

0.479

High

884708

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

884711

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

3

Small-scale

0.479

High

884713

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.479

High

884716

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

884718

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

884721

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

4

High-throughput

0.479

High

281915

MPPB
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.458

High

350817

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

519078

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

851844

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

884623

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

884651

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

884659

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

884684

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

884693

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

884703

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

884704

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

884730

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

884626

EF1A2
Elongation factor 1-alpha 2

1

1

High-throughput

0.445

High

884650

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

588188

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

694911

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

767684

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

884656

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

884658

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

884707

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

549746

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.328

High

884676

F174A
Membrane protein FAM174A

2

0

High-throughput

0.328

High

884688

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

884696

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

884725

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

884726

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

884654

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

189456

STX7
Syntaxin-7

1

0

High-throughput

0.279

Low

231795

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.279

Low

377091

PDYN
Proenkephalin-B

1

0

High-throughput

0.279

Low

634960

NTF3
Neurotrophin-3

1

0

High-throughput

0.279

Low

829890

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.279

Low

884632

TROAP
Tastin

1

0

High-throughput

0.279

Low

884637

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.279

Low

884644

ASTRB
Protein Aster-B

1

0

High-throughput

0.279

Low

884645

YIF1B
Protein YIF1B

1

0

High-throughput

0.279

Low

884647

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.279

Low

884648

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

884655

KLH17
Kelch-like protein 17

1

0

High-throughput

0.279

Low

884657

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.279

Low

884668

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

884669

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.279

Low

884670

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.279

Low

884675

SRARP
Steroid receptor-associated and regulated protein

1

0

High-throughput

0.279

Low

884678

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

884679

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

0

High-throughput

0.279

Low

884687

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

884690

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

0

High-throughput

0.279

Low

884692

SERC2
Serine incorporator 2

1

0

High-throughput

0.279

Low

884701

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.279

Low

884702

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

884715

SEP11
Septin-11

1

0

High-throughput

0.279

Low

884720

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

884727

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.279

Low

884663

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025