Protein: FBXL5
F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein)

Gene: FBXL5
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q9UKA1

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005506 - iron ion binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992382

SKP1
S-phase kinase-associated protein 1

14

0

Small-scale

0.934

High

1112779

CUL1
Cullin-1

12

0

Small-scale

0.927

High

870978

IREB2
Iron-responsive element-binding protein 2

6

1

Small-scale

0.741

High

343103

HERC2
E3 ubiquitin-protein ligase HERC2

4

1

Small-scale

0.694

High

1403611

MMS19
MMS19 nucleotide excision repair protein homolog

5

0

Small-scale

0.684

High

1460977

CIA2B
Cytosolic iron-sulfur assembly component 2B

4

0

Small-scale

0.664

High

1370454

CSN5
COP9 signalosome complex subunit 5

3

0

High-throughput

0.646

High

638160

ACOHC
Cytoplasmic aconitate hydratase

3

1

Small-scale

0.640

High

1460976

CSN3
COP9 signalosome complex subunit 3

2

1

High-throughput

0.628

High

920350

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.622

High

350175

SNAI1
Zinc finger protein SNAI1

2

0

Small-scale

0.607

High

284628

ECI2
Enoyl-CoA delta isomerase 2

2

0

High-throughput

0.602

High

704462

GRAN
Grancalcin

2

0

High-throughput

0.602

High

958735

CSN2
COP9 signalosome complex subunit 2

2

0

High-throughput

0.602

High

1272591

CSN6
COP9 signalosome complex subunit 6

2

0

High-throughput

0.602

High

1366000

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.602

High

1410287

KLDC3
Kelch domain-containing protein 3

2

0

High-throughput

0.602

High

1432298

ZN106
Zinc finger protein 106

2

0

High-throughput

0.602

High

1460978

ARI1
E3 ubiquitin-protein ligase ARIH1

2

0

High-throughput

0.602

High

984016

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.576

High

1201091

ACTBL
Beta-actin-like protein 2

2

1

High-throughput

0.574

High

1123865

DCTN1
Dynactin subunit 1

1

0

Small-scale

0.549

High

791823

SYUA
Alpha-synuclein

1

0

Small-scale

0.537

High

1409903

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.537

High

953172

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

1408441

CITE2
Cbp/p300-interacting transactivator 2

1

0

Small-scale

0.520

High

684520

CTNA2
Catenin alpha-2

1

0

High-throughput

0.513

High

842021

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

883958

CENPF
Centromere protein F

1

0

High-throughput

0.513

High

1458845

CSN7A
COP9 signalosome complex subunit 7a

1

0

High-throughput

0.513

High

1096264

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

995340

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

231530

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.460

High

1067819

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.460

High

519435

MYB
Transcriptional activator Myb

1

0

High-throughput

0.458

High

548638

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

623640

TFEB
Transcription factor EB

1

0

Small-scale

0.458

High

912642

GDIR2
Rho GDP-dissociation inhibitor 2

1

0

Small-scale

0.458

High

974910

BTG1
Protein BTG1

1

0

Small-scale

0.458

High

1399310

MUS81
Structure-specific endonuclease subunit MUS81

1

0

Small-scale

0.458

High

1439002

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

Small-scale

0.458

High

302994

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

3

0

Small-scale

0.347

High

1186329

MA7D1
MAP7 domain-containing protein 1

2

0

High-throughput

0.328

High

1395423

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.328

High

1328145

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025