Protein: PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta)

Gene: PP2BB, PPP3CB
Organism: Homo sapiens
Interactions: 85
UniProt ID: P16298

Gene Ontology (top 5):
GO:0001913 - T cell mediated cytotoxicity
GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0001946 - lymphangiogenesis
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

593819

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

4

13

High-throughput

0.892

High

593824

RCAN1
Calcipressin-1

5

11

High-throughput

0.722

High

593878

RCAN3
Calcipressin-3

4

11

High-throughput

0.699

High

593830

CANB1
Calcineurin subunit B type 1

1

20

High-throughput

0.691

High

593836

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

14

High-throughput

0.691

High

593869

CANB2
Calcineurin subunit B type 2

1

20

High-throughput

0.691

High

539107

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

5

High-throughput

0.667

High

593841

RCAN2
Calcipressin-2

3

11

High-throughput

0.667

High

593821

GSK3A
Glycogen synthase kinase-3 alpha

2

18

High-throughput

0.628

High

593859

PAR3L
Partitioning defective 3 homolog B

1

19

High-throughput

0.618

High

375148

RASK
GTPase KRas

1

3

High-throughput

0.618

High

62093

KLRG2
Killer cell lectin-like receptor subfamily G member 2

3

2

High-throughput

0.604

High

593853

T200A
Transmembrane protein 200A

3

2

High-throughput

0.604

High

571548

IRF2
Interferon regulatory factor 2

1

2

High-throughput

0.586

High

593823

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.578

High

516307

CALM1
Calmodulin-1

1

16

High-throughput

0.575

High

516381

CALM2
Calmodulin-2

1

16

High-throughput

0.575

High

516463

CALM3
Calmodulin-3

1

16

High-throughput

0.575

High

593814

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

16

High-throughput

0.575

High

593817

PI4KA
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.575

High

593820

RGS3
Regulator of G-protein signaling 3

1

2

High-throughput

0.575

High

593827

DEF1
Neutrophil defensin 1

2

2

High-throughput

0.574

High

593840

GRB10
Growth factor receptor-bound protein 10

2

12

High-throughput

0.571

High

593861

SH3K1
SH3 domain-containing kinase-binding protein 1

2

10

High-throughput

0.571

High

593845

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

19

High-throughput

0.553

High

593846

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.553

High

362712

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.541

High

593834

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

8

High-throughput

0.541

High

593839

PTK7
Inactive tyrosine-protein kinase 7

1

4

High-throughput

0.541

High

593855

LMTK2
Serine/threonine-protein kinase LMTK2

1

13

High-throughput

0.541

High

429252

JUN
Transcription factor Jun

1

8

Small-scale

0.536

High

593812

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

593815

HSPA9
Stress-70 protein, mitochondrial

1

16

High-throughput

0.536

High

593831

HXC5
Homeobox protein Hox-C5

1

1

High-throughput

0.536

High

593833

CDR2
Cerebellar degeneration-related protein 2

1

1

High-throughput

0.536

High

593838

AHNK
Neuroblast differentiation-associated protein AHNAK

1

3

High-throughput

0.536

High

593842

RBM39
RNA-binding protein 39

1

10

High-throughput

0.536

High

593844

ZYX
Zyxin

1

5

High-throughput

0.536

High

593847

CRTC2
CREB-regulated transcription coactivator 2

1

7

High-throughput

0.536

High

593848

LBH
Protein LBH

1

2

High-throughput

0.536

High

593852

KCNKI
Potassium channel subfamily K member 18

1

2

High-throughput

0.536

High

593856

TENS4
Tensin-4

1

7

High-throughput

0.536

High

593860

PMEPA
Protein TMEPAI

1

2

High-throughput

0.536

High

593864

SPF45
Splicing factor 45

1

4

High-throughput

0.536

High

593866

ASPP1
Apoptosis-stimulating of p53 protein 1

1

20

High-throughput

0.536

High

593870

SPT33
Spermatogenesis-associated protein 33

1

2

High-throughput

0.536

High

593874

ARMT1
Damage-control phosphatase ARMT1

1

1

High-throughput

0.536

High

105268

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

593832

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

593871

ATOH8
Transcription factor ATOH8

1

3

Small-scale

0.515

High

593835

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.513

High

593851

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

593865

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.513

High

593849

LMTK1
Serine/threonine-protein kinase LMTK1

1

18

High-throughput

0.494

High

504684

F163B
Protein FAM163B

1

2

High-throughput

0.489

High

593813

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.489

High

593873

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

2

Small-scale

0.481

High

593876

FXL17
F-box/LRR-repeat protein 17

1

4

Small-scale

0.481

High

328466

CAC1H
Voltage-dependent T-type calcium channel subunit alpha-1H

1

4

Small-scale

0.479

High

334332

TRI16
Tripartite motif-containing protein 16

1

8

Small-scale

0.479

High

371086

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

593811

TFEB
Transcription factor EB

1

8

Small-scale

0.479

High

593816

MLH1
DNA mismatch repair protein Mlh1

1

5

High-throughput

0.479

High

593822

RASF2
Ras association domain-containing protein 2

1

2

High-throughput

0.479

High

593826

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.479

High

593829

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.479

High

593837

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

3

Small-scale

0.479

High

593850

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

593858

CEP76
Centrosomal protein of 76 kDa

1

1

High-throughput

0.479

High

593862

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.479

High

593868

CI072
Guanine nucleotide exchange factor C9orf72

1

5

High-throughput

0.479

High

593872

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.479

High

593875

ANLN
Anillin

1

3

High-throughput

0.479

High

593877

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

593854

TB10C
Carabin

1

2

Small-scale

0.457

High

404655

PRIO
Major prion protein

1

1

High-throughput

0.445

High

529010

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

593825

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

593828

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.445

High

593879

S4A7
Sodium bicarbonate cotransporter 3

1

2

High-throughput

0.445

High

593818

MAGA3
Melanoma-associated antigen 3

1

2

Small-scale

0.437

High

593843

ADIPO
Adiponectin

1

4

High-throughput

0.407

High

593863

ESS2
Splicing factor ESS-2 homolog

1

2

High-throughput

0.407

High

593867

F167A
Protein FAM167A

1

1

High-throughput

0.407

High

593857

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025