Protein: ACY1
Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase)

Gene: ACY1
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q03154

Gene Ontology (top 5):
GO:0004046 - aminoacylase activity
GO:0005829 - cytosol
GO:0006520 - amino acid metabolic process
GO:0042802 - identical protein binding
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041447

ACY1
Aminoacylase-1

6

12

Small-scale

0.942

High

785820

8ODP
Oxidized purine nucleoside triphosphate hydrolase

6

1

High-throughput

0.733

High

938209

SEC13
Protein SEC13 homolog

3

0

High-throughput

0.638

High

1041456

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

3

0

High-throughput

0.638

High

1041464

PECR
Peroxisomal trans-2-enoyl-CoA reductase

3

0

High-throughput

0.638

High

1041462

TTC1
Tetratricopeptide repeat protein 1

2

3

High-throughput

0.608

High

1041460

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1041467

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

479799

GSTP1
Glutathione S-transferase P

1

1

High-throughput

0.536

High

630773

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.536

High

446928

NPM
Nucleophosmin

1

0

High-throughput

0.518

High

1041469

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.513

High

421962

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

133243

P2Y10
Putative P2Y purinoceptor 10

1

1

High-throughput

0.489

High

125834

AP4M1
AP-4 complex subunit mu-1

1

1

High-throughput

0.479

High

241450

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

519961

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

1041468

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1041461

BBS4
BBSome complex member BBS4

1

1

Small-scale

0.457

High

1041465

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

1041452

BBS7
BBSome complex member BBS7

1

0

Small-scale

0.438

High

1041463

BBS2
BBSome complex member BBS2

1

0

Small-scale

0.438

High

1041451

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1041459

RN166
E3 ubiquitin-protein ligase RNF166

1

1

High-throughput

0.437

High

1041471

PPME1
Protein phosphatase methylesterase 1

4

0

High-throughput

0.360

High

1041455

BOLL
Protein boule-like

3

0

High-throughput

0.347

High

1041470

TRI33
E3 ubiquitin-protein ligase TRIM33

3

0

High-throughput

0.342

High

1041449

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

2

0

High-throughput

0.318

High

1041472

ICOS
Inducible T-cell costimulator

2

0

High-throughput

0.318

High

224980

TLX3
T-cell leukemia homeobox protein 3

2

0

High-throughput

0.316

High

297964

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.316

High

506720

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1041458

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.316

High

928424

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.299

High

1041466

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

182511

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

1041450

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

1041453

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

431554

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.238

Low

127057

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.232

Low

330125

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

880130

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.232

Low

926762

VMAT1
Chromaffin granule amine transporter

1

0

High-throughput

0.232

Low

1041448

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1041454

TSYL6
Testis-specific Y-encoded-like protein 6

1

0

High-throughput

0.232

Low

1041457

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025