Interactor 1: CO2 (P06681)
Complement C2 (C3/C5 convertase) [Cleaved into: Complement C2a; Serine protease complement C2b (EC 3.4.21.43)]
Gene: C2
Interactor 2: C1S (P09871)
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain (Complement C1s subcomponent chain A); Complement C1s subcomponent light chain (Complement C1s subcomponent chain B)]
Gene: C1S
Species: Homo sapiens
Source: innatedb
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.50 | 1.00 | 0.712 |
The method score is based on:
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CUB~Sushi, Sushi~Sushi, Sushi~Trypsin, CUB~Trypsin, FXa_inhibition~Trypsin, Trypsin~Trypsin, Sushi~VWA, Trypsin~VWA |
| Common GO terms | GO:0004252 - serine-type endopeptidase activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006508 - proteolysis GO:0006958 - complement activation, classical pathway and 1 others more... |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
