Protein: IFNG
Interferon gamma (IFN-gamma) (Immune interferon)

Gene: IFNG
Organism: Homo sapiens
Interactions: 48
UniProt ID: P01579

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001774 - microglial cell activation
GO:0001819 - positive regulation of cytokine production
GO:0002250 - adaptive immune response
GO:0002281 - macrophage activation involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378411

INGR1
Interferon gamma receptor 1

8

1

Small-scale

0.973

High

378417

INGR2
Interferon gamma receptor 2

1

1

Small-scale

0.724

High

378414

CREB1
Cyclic AMP-responsive element-binding protein 1

2

2

Small-scale

0.618

High

378405

JUN
Transcription factor Jun

2

5

Small-scale

0.601

High

378432

STAT4
Signal transducer and activator of transcription 4

2

3

Small-scale

0.584

High

378402

IFNG
Interferon gamma

1

0

Small-scale

0.546

High

378425

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

378426

ACTA
Actin, aortic smooth muscle

1

1

High-throughput

0.536

High

378436

LMO7
LIM domain only protein 7

1

1

High-throughput

0.536

High

378412

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

4

Small-scale

0.534

High

378403

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.513

High

378404

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.513

High

378421

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.513

High

378441

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.513

High

378408

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.512

High

378420

STAT6
Signal transducer and activator of transcription 6

1

3

Small-scale

0.501

High

378446

LIMC1
LIM and calponin homology domains-containing protein 1

1

1

High-throughput

0.489

High

378415

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

3

Small-scale

0.479

High

378418

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.479

High

378419

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

Small-scale

0.479

High

378423

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.479

High

378427

CREM
cAMP-responsive element modulator

1

2

Small-scale

0.479

High

378428

TF65
Transcription factor p65

1

2

Small-scale

0.479

High

378445

TBX21
T-box transcription factor TBX21

1

1

Small-scale

0.479

High

378410

I23O1
Indoleamine 2,3-dioxygenase 1

1

0

Small-scale

0.458

High

378430

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.458

High

378438

PROX1
Prospero homeobox protein 1

1

0

Small-scale

0.458

High

378406

MMP3
Stromelysin-1

1

0

High-throughput

0.426

High

378407

C1S
Complement C1s subcomponent

1

0

High-throughput

0.426

High

378409

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

378416

S100P
Protein S100-P

1

0

High-throughput

0.426

High

378429

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.426

High

378434

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.426

High

378439

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.426

High

378444

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.426

High

378447

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

378442

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

0

High-throughput

0.328

High

142662

TRI38
E3 ubiquitin-protein ligase TRIM38

1

0

High-throughput

0.279

Low

378424

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.279

Low

378433

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.279

Low

378437

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.279

Low

378435

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

378413

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

378422

HSP13
Heat shock 70 kDa protein 13

1

0

High-throughput

0.232

Low

378431

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.232

Low

378440

ZN496
Zinc finger protein 496

1

0

High-throughput

0.232

Low

378443

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025