Protein: FBX28
F-box only protein 28

Gene: FBX28, FBXO28
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9NVF7

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000776 - kinetochore
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992353

SKP1
S-phase kinase-associated protein 1

15

1

Small-scale

0.983

High

1112735

CUL1
Cullin-1

6

0

Small-scale

0.779

High

1240782

PMF1
Polyamine-modulated factor 1

4

0

High-throughput

0.663

High

1090947

TRAF2
TNF receptor-associated factor 2

5

3

High-throughput

0.660

High

1097235

PAK2
Serine/threonine-protein kinase PAK 2

4

1

High-throughput

0.643

High

1063646

GOGA2
Golgin subfamily A member 2

4

1

High-throughput

0.642

High

1110740

DCTN2
Dynactin subunit 2

3

0

High-throughput

0.638

High

136730

TRAF5
TNF receptor-associated factor 5

4

3

High-throughput

0.638

High

1450436

EMIL1
EMILIN-1

4

1

High-throughput

0.638

High

1140202

ARHG6
Rho guanine nucleotide exchange factor 6

4

1

High-throughput

0.630

High

1449316

HOME3
Homer protein homolog 3

4

1

High-throughput

0.629

High

1450421

FBX28
F-box only protein 28

3

0

Small-scale

0.625

High

1096507

PAK1
Serine/threonine-protein kinase PAK 1

3

1

High-throughput

0.616

High

1340679

NEDD1
Protein NEDD1

3

1

High-throughput

0.616

High

1093974

TRAF1
TNF receptor-associated factor 1

3

2

Small-scale

0.609

High

1295219

HOME1
Homer protein homolog 1

3

1

High-throughput

0.609

High

1408263

EGFL8
Epidermal growth factor-like protein 8

3

1

High-throughput

0.609

High

1450431

CLC11
C-type lectin domain family 11 member A

3

1

High-throughput

0.609

High

1121988

ARHG7
Rho guanine nucleotide exchange factor 7

3

1

High-throughput

0.604

High

1438582

EMAL4
Echinoderm microtubule-associated protein-like 4

3

1

High-throughput

0.604

High

1450434

GIT1
ARF GTPase-activating protein GIT1

3

1

High-throughput

0.604

High

134961

EMAL1
Echinoderm microtubule-associated protein-like 1

2

1

High-throughput

0.574

High

178679

ANGP2
Angiopoietin-2

2

1

High-throughput

0.574

High

191976

TEX28
Testis-specific protein TEX28

2

1

High-throughput

0.574

High

1122451

GIT2
ARF GTPase-activating protein GIT2

2

1

High-throughput

0.574

High

1384278

SH3K1
SH3 domain-containing kinase-binding protein 1

2

2

High-throughput

0.574

High

1450427

TMCC3
Transmembrane and coiled-coil domain protein 3

2

1

High-throughput

0.574

High

1450435

ANGL3
Angiopoietin-related protein 3

2

1

High-throughput

0.574

High

65175

GG6L9
Golgin subfamily A member 6-like protein 9

2

1

High-throughput

0.553

High

1449491

EMIL3
EMILIN-3

2

1

High-throughput

0.553

High

1401175

SPAG5
Sperm-associated antigen 5

1

0

High-throughput

0.549

High

221812

SNAI2
Zinc finger protein SNAI2

1

1

Small-scale

0.512

High

1249716

CLC4G
C-type lectin domain family 4 member G

1

1

High-throughput

0.489

High

1323672

CLC4F
C-type lectin domain family 4 member F

1

1

High-throughput

0.489

High

329987

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.458

High

1347563

SMRC2
SWI/SNF complex subunit SMARCC2

1

0

Small-scale

0.458

High

461975

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.437

High

468845

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.437

High

1450433

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

2

High-throughput

0.407

High

610488

PRS6A
26S proteasome regulatory subunit 6A

5

0

High-throughput

0.374

High

1239959

CAVN1
Caveolae-associated protein 1

5

0

High-throughput

0.373

High

1058685

CKAP4
Cytoskeleton-associated protein 4

4

0

High-throughput

0.363

High

1430870

SDCB2
Syntenin-2

3

0

High-throughput

0.352

High

1436609

PKHF2
Pleckstrin homology domain-containing family F member 2

3

0

High-throughput

0.352

High

1308137

LUR1L
Leucine rich adaptor protein 1-like

3

0

High-throughput

0.347

High

1450425

NUP50
Nuclear pore complex protein Nup50

3

0

High-throughput

0.347

High

1246166

TRAF7
E3 ubiquitin-protein ligase TRAF7

3

0

High-throughput

0.345

High

1258695

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

3

0

High-throughput

0.345

High

1351650

TCP1L
T-complex protein 10A homolog 1

3

0

High-throughput

0.345

High

321051

SUN1
SUN domain-containing protein 1

2

0

High-throughput

0.328

High

1178961

TM266
Transmembrane protein 266

2

0

High-throughput

0.328

High

1295410

RFIP4
Rab11 family-interacting protein 4

2

0

High-throughput

0.328

High

1331747

CCD89
Coiled-coil domain-containing protein 89

2

0

High-throughput

0.328

High

1349439

POC1B
POC1 centriolar protein homolog B

2

0

High-throughput

0.328

High

1415474

NUP58
Nucleoporin p58/p45

2

0

High-throughput

0.328

High

1420649

LRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

2

0

High-throughput

0.328

High

1439566

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

0

High-throughput

0.328

High

1447142

PFD4
Prefoldin subunit 4

2

0

High-throughput

0.328

High

1450423

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.328

High

960357

STX1B
Syntaxin-1B

2

0

High-throughput

0.316

High

1324664

AGGF1
Angiogenic factor with G patch and FHA domains 1

2

0

High-throughput

0.316

High

1386142

GCC1
GRIP and coiled-coil domain-containing protein 1

2

0

High-throughput

0.316

High

1450424

CTNA3
Catenin alpha-3

2

0

High-throughput

0.316

High

1450430

EXOC7
Exocyst complex component 7

2

0

High-throughput

0.316

High

1415424

TMED9
Transmembrane emp24 domain-containing protein 9

2

0

High-throughput

0.313

High

397047

ESR1
Estrogen receptor

2

0

High-throughput

0.298

High

1383568

MCUR1
Mitochondrial calcium uniporter regulator 1

2

0

High-throughput

0.298

High

542672

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.292

High

1164320

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

0

Small-scale

0.288

High

167532

TX1B3
Tax1-binding protein 3

1

0

High-throughput

0.279

Low

455878

H10
Histone H1.0

1

0

High-throughput

0.279

Low

601947

ZNF7
Zinc finger protein 7

1

0

High-throughput

0.279

Low

867455

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

911400

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.279

Low

1013114

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.279

Low

1134748

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.279

Low

1163242

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.279

Low

1234624

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.279

Low

1235630

K2C80
Keratin, type II cytoskeletal 80

1

0

High-throughput

0.279

Low

1249927

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

1

0

High-throughput

0.279

Low

1257304

STXB4
Syntaxin-binding protein 4

1

0

High-throughput

0.279

Low

1292773

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1315932

RASEF
Ras and EF-hand domain-containing protein

1

0

High-throughput

0.279

Low

1328136

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low

1331160

LSME1
Leucine-rich single-pass membrane protein 1

1

0

High-throughput

0.279

Low

1348875

FA81A
Protein FAM81A

1

0

High-throughput

0.279

Low

1399397

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

High-throughput

0.279

Low

1400154

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.279

Low

1408483

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.279

Low

1450422

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.279

Low

1450426

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.279

Low

1450428

HSF4
Heat shock factor protein 4

1

0

High-throughput

0.279

Low

1450429

SOX13
Transcription factor SOX-13

1

0

High-throughput

0.279

Low

998059

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.261

Low

732854

GLPK
Glycerol kinase

1

0

High-throughput

0.251

Low

822881

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.251

Low

218839

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

346402

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

463794

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.249

Low

888347

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

980417

H4
Histone H4

1

0

High-throughput

0.249

Low

1013180

SARNP
SAP domain-containing ribonucleoprotein

1

0

Small-scale

0.249

Low

1045824

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1151093

PCH2
Pachytene checkpoint protein 2 homolog

1

0

Small-scale

0.249

Low

1161414

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.249

Low

1214811

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

Small-scale

0.249

Low

1271018

RHOU
Rho-related GTP-binding protein RhoU

1

0

High-throughput

0.249

Low

1415971

IFT27
Intraflagellar transport protein 27 homolog

1

0

Small-scale

0.249

Low

1278934

BRAP
BRCA1-associated protein

1

0

Small-scale

0.238

Low

186383

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.232

Low

1450432

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025