Protein: CI072
Guanine nucleotide exchange factor C9orf72

Gene: CI072, C9orf72
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q96LT7

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0001933 - negative regulation of protein phosphorylation
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1256811

SMCR8
Guanine nucleotide exchange protein SMCR8

8

1

Small-scale

0.977

High

1297411

WDR41
WD repeat-containing protein 41

5

0

Small-scale

0.692

High

834444

EI2BB
Translation initiation factor eIF2B subunit beta

4

2

High-throughput

0.690

High

262304

ULK1
Serine/threonine-protein kinase ULK1

5

0

Small-scale

0.676

High

1255658

RBCC1
RB1-inducible coiled-coil protein 1

5

0

Small-scale

0.673

High

255188

ATG13
Autophagy-related protein 13

4

0

Small-scale

0.665

High

1287954

RB39B
Ras-related protein Rab-39B

2

4

Small-scale

0.595

High

1297410

VRTN
Vertnin

2

0

High-throughput

0.589

High

845675

RAB9A
Ras-related protein Rab-9A

2

5

High-throughput

0.584

High

275655

POP7
Ribonuclease P protein subunit p20

2

0

High-throughput

0.580

High

750426

COIL
Coilin

2

0

High-throughput

0.580

High

1297412

HM20A
High mobility group protein 20A

2

0

High-throughput

0.580

High

894793

RAB8A
Ras-related protein Rab-8A

1

2

Small-scale

0.561

High

228388

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1297404

ATGA1
Autophagy-related protein 101

2

0

Small-scale

0.559

High

197802

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.549

High

981693

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

1030687

NMI
N-myc-interactor

1

0

High-throughput

0.549

High

1297399

SRPK1
SRSF protein kinase 1

1

0

High-throughput

0.545

High

918931

RAB1A
Ras-related protein Rab-1A

1

2

Small-scale

0.529

High

1122064

Q53XC2
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.515

High

1200190

TRI74
Tripartite motif-containing protein 74

1

1

High-throughput

0.515

High

1297402

Q9BPX4
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.515

High

1297423

TBK1
Serine/threonine-protein kinase TBK1

1

1

Small-scale

0.501

High

1200201

TRI73
Tripartite motif-containing protein 73

1

1

High-throughput

0.481

High

395508

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

64826

TBKB1
TANK-binding kinase 1-binding protein 1

1

1

Small-scale

0.479

High

434265

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.479

High

564646

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.479

High

592695

RAB6A
Ras-related protein Rab-6A

1

2

Small-scale

0.479

High

845175

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

884451

RAB38
Ras-related protein Rab-38

1

5

Small-scale

0.479

High

900806

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

951240

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1048030

RB33A
Ras-related protein Rab-33A

1

4

Small-scale

0.479

High

1060519

RB39A
Ras-related protein Rab-39A

1

4

Small-scale

0.479

High

1070345

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1153248

RAB12
Ras-related protein Rab-12

1

3

Small-scale

0.479

High

1273007

RAB8B
Ras-related protein Rab-8B

1

2

Small-scale

0.479

High

1296045

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1297408

AZI2
5-azacytidine-induced protein 2

1

1

Small-scale

0.479

High

1297429

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.479

High

1089291

Q17R54
Synapsin III

1

1

High-throughput

0.470

High

1297397

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.460

High

205847

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

304868

MFN2
Mitofusin-2

1

0

High-throughput

0.458

High

527720

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.458

High

573863

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

575825

VINC
Vinculin

1

0

High-throughput

0.458

High

654677

CALX
Calnexin

1

0

High-throughput

0.458

High

665516

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.458

High

783092

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

839055

EMD
Emerin

1

0

High-throughput

0.458

High

1053136

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1146741

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.458

High

1152043

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1271742

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.458

High

1297400

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1297401

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1297415

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1297416

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1297417

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1297425

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1297426

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

164314

ZN646
Zinc finger protein 646

1

2

Small-scale

0.445

High

383937

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

Small-scale

0.445

High

682651

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

1

Small-scale

0.445

High

1230631

ZN567
Zinc finger protein 567

1

1

Small-scale

0.445

High

1297398

ZN300
Zinc finger protein 300

1

1

Small-scale

0.445

High

1297409

ESRP2
Epithelial splicing regulatory protein 2

1

1

Small-scale

0.445

High

1297421

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

1

1

Small-scale

0.445

High

1297424

ZN256
Zinc finger protein 256

1

1

Small-scale

0.445

High

164078

SYN3
Synapsin-3

1

1

High-throughput

0.439

High

526023

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

884566

RAB25
Ras-related protein Rab-25

1

1

Small-scale

0.437

High

965803

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1220627

MIRO2
Mitochondrial Rho GTPase 2

1

6

High-throughput

0.437

High

1297407

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1297419

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.437

High

151511

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

0

Small-scale

0.426

High

278652

DCTN3
Dynactin subunit 3

1

0

Small-scale

0.426

High

401044

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.426

High

451535

CLCA
Clathrin light chain A

1

0

Small-scale

0.426

High

591057

BTF3
Transcription factor BTF3

1

0

Small-scale

0.426

High

640144

MOES
Moesin

1

0

Small-scale

0.426

High

726993

FUS
RNA-binding protein FUS

1

0

Small-scale

0.426

High

911043

RS29
Small ribosomal subunit protein uS14

1

0

Small-scale

0.426

High

912357

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

Small-scale

0.426

High

922081

RL39
Large ribosomal subunit protein eL39

1

0

Small-scale

0.426

High

924389

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

Small-scale

0.426

High

929035

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.426

High

987456

MTG8
Protein CBFA2T1

1

0

Small-scale

0.426

High

1040827

PWP1
Periodic tryptophan protein 1 homolog

1

0

Small-scale

0.426

High

1202664

TSYL5
Testis-specific Y-encoded-like protein 5

1

0

Small-scale

0.426

High

1219820

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

Small-scale

0.426

High

1263507

PSPC1
Paraspeckle component 1

1

0

Small-scale

0.426

High

1297403

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

Small-scale

0.426

High

1297405

BTBDA
BTB/POZ domain-containing protein 10

1

0

Small-scale

0.426

High

1297406

RPAP1
RNA polymerase II-associated protein 1

1

0

Small-scale

0.426

High

1297420

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

Small-scale

0.426

High

1297427

PKP3
Plakophilin-3

1

0

Small-scale

0.426

High

1297428

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

0

Small-scale

0.426

High

1205604

F90A1
Protein FAM90A1

1

0

High-throughput

0.279

Low

456917

FURIN
Furin

1

0

High-throughput

0.249

Low

1072803

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

1190064

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.249

Low

1283913

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1294340

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.249

Low

1297413

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1297414

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

1297418

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.249

Low

1297422

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.249

Low

173086

RT12
Small ribosomal subunit protein uS12m

1

0

Small-scale

0.232

Low

1048894

BOP1
Ribosome biogenesis protein BOP1

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024