Protein: NPRL2
GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)

Gene: NPRL2
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q8WTW4

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0005774 - vacuolar membrane
GO:0010508 - positive regulation of autophagy
GO:0033673 - negative regulation of kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

271364

DEPD5
GATOR1 complex protein DEPDC5

9

3

Small-scale

0.972

High

1091890

NPRL3
GATOR1 complex protein NPRL3

8

2

Small-scale

0.966

High

1356187

WDR24
GATOR2 complex protein WDR24

3

4

Small-scale

0.847

High

1245315

WDR59
GATOR2 complex protein WDR59

3

6

Small-scale

0.827

High

1272157

RRAGA
Ras-related GTP-binding protein A

3

4

Small-scale

0.827

High

1211531

SZT2
KICSTOR complex protein SZT2

3

0

Small-scale

0.622

High

1219782

RRAGB
Ras-related GTP-binding protein B

1

4

Small-scale

0.618

High

1356179

SEH1
Nucleoporin SEH1

1

6

Small-scale

0.618

High

1356191

RRAGC
Ras-related GTP-binding protein C

1

4

Small-scale

0.618

High

1356192

RRAGD
Ras-related GTP-binding protein D

1

4

Small-scale

0.618

High

1169427

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

1322601

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.586

High

1356178

ITFG2
KICSTOR complex protein ITFG2

2

0

Small-scale

0.585

High

1356194

MIOS
GATOR2 complex protein MIOS

2

4

Small-scale

0.584

High

161737

APAF
Apoptotic protease-activating factor 1

1

0

High-throughput

0.578

High

945676

SESN2
Sestrin-2

1

0

Small-scale

0.513

High

1116680

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.513

High

1245047

TRI65
E3 ubiquitin-protein ligase TRIM65

1

0

High-throughput

0.513

High

231742

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.489

High

1017453

FOXK1
Forkhead box protein K1

1

1

High-throughput

0.489

High

1029717

FOXK2
Forkhead box protein K2

1

1

High-throughput

0.489

High

1112257

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.489

High

1187164

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

1

High-throughput

0.489

High

1356173

CTF18
Chromosome transmission fidelity protein 18 homolog

1

1

High-throughput

0.489

High

808126

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

537589

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

540587

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

1356185

KICS2
KICSTOR subunit 2

1

0

Small-scale

0.458

High

1356201

KPTN
KICSTOR complex protein kaptin

1

0

Small-scale

0.458

High

1356193

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.437

High

378434

IFNG
Interferon gamma

1

0

High-throughput

0.426

High

1356182

ZN414
Zinc finger protein 414

3

0

High-throughput

0.347

High

176410

ZBTB5
Zinc finger and BTB domain-containing protein 5

2

0

High-throughput

0.328

High

1218301

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

2

0

High-throughput

0.328

High

1356176

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.328

High

957453

UBC12
NEDD8-conjugating enzyme Ubc12

2

0

Small-scale

0.313

High

1356175

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

193799

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.279

Low

298611

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

335334

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

0

High-throughput

0.279

Low

441497

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.279

Low

628817

TBP
TATA-box-binding protein

1

0

High-throughput

0.279

Low

1109634

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

1137246

CND1
Condensin complex subunit 1

1

0

High-throughput

0.279

Low

1152933

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.279

Low

1157543

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.279

Low

1201857

PKHG4
Puratrophin-1

1

0

High-throughput

0.279

Low

1243208

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

1244262

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.279

Low

1245211

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.279

Low

1257278

STXB4
Syntaxin-binding protein 4

1

0

High-throughput

0.279

Low

1294050

MEX3D
RNA-binding protein MEX3D

1

0

High-throughput

0.279

Low

1331986

BANP
Protein BANP

1

0

High-throughput

0.279

Low

1336152

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1356174

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.279

Low

1356177

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

0

High-throughput

0.279

Low

1356180

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

High-throughput

0.279

Low

1356181

TONSL
Tonsoku-like protein

1

0

High-throughput

0.279

Low

1356183

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

1356184

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low

1356186

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

1356188

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.279

Low

1356190

ARP5
Actin-related protein 5

1

0

High-throughput

0.279

Low

1356199

FBX7
F-box only protein 7

1

0

High-throughput

0.279

Low

1356200

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.279

Low

531115

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

0

High-throughput

0.269

Low

627998

ANXA7
Annexin A7

1

0

High-throughput

0.265

Low

259009

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.249

Low

342980

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.249

Low

375767

RASK
GTPase KRas

1

0

High-throughput

0.249

Low

461753

HS90A
Heat shock protein HSP 90-alpha

1

0

High-throughput

0.249

Low

557400

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.249

Low

660123

COF1
Cofilin-1

1

0

High-throughput

0.249

Low

731499

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.249

Low

764911

CTNB1
Catenin beta-1

1

0

High-throughput

0.249

Low

791028

TALDO
Transaldolase

1

0

High-throughput

0.249

Low

846397

MATR3
Matrin-3

1

0

High-throughput

0.249

Low

976914

ERR3
Estrogen-related receptor gamma

1

0

High-throughput

0.249

Low

1030747

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.249

Low

1108628

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.249

Low

1134300

IMB1
Importin subunit beta-1

1

0

High-throughput

0.249

Low

1142607

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.249

Low

1146744

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.249

Low

1247746

NHS
Actin remodeling regulator NHS

1

0

High-throughput

0.249

Low

1356189

TB182
182 kDa tankyrase-1-binding protein

1

0

High-throughput

0.249

Low

1356195

CING
Cingulin

1

0

High-throughput

0.249

Low

1356196

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.249

Low

1356197

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.249

Low

1356198

RUVB2
RuvB-like 2

1

0

High-throughput

0.249

Low

1356202

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.249

Low

856831

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.232

Low

1272407

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025