Protein: PTK2
Serine/threonine-protein kinase PTK2/STK2 (EC 2.7.11.1)

Gene: PTK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 235
UniProt ID: P47116

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000296 - spermine transport
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364623

CDK1
Cyclin-dependent kinase 1

2

17

Small-scale

0.807

High

807104

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

9

High-throughput

0.691

High

817265

ARB1
ABC transporter ATP-binding protein ARB1

1

3

High-throughput

0.691

High

865535

PKH1
Serine/threonine-protein kinase PKH1

1

19

High-throughput

0.691

High

445352

CDC31
Cell division control protein 31

1

19

High-throughput

0.665

High

437936

KAPC
cAMP-dependent protein kinase type 3

1

12

High-throughput

0.647

High

464617

PBS2
MAP kinase kinase PBS2

1

19

High-throughput

0.647

High

518067

SSBP1
Single-stranded nucleic acid-binding protein

1

5

High-throughput

0.647

High

574591

YAK1
Dual specificity protein kinase YAK1

1

19

High-throughput

0.647

High

646058

KIN3
Serine/threonine-protein kinase KIN3

1

19

High-throughput

0.647

High

660333

STE11
Serine/threonine-protein kinase STE11

1

17

High-throughput

0.647

High

692583

NSR1
Nuclear localization sequence-binding protein

1

7

High-throughput

0.647

High

704690

PRR1
Serine/threonine-protein kinase PRR1

1

16

High-throughput

0.647

High

778947

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

17

High-throughput

0.647

High

792724

YPK3
Serine/threonine-protein kinase YPK3

1

20

High-throughput

0.647

High

793171

AKL1
Serine/threonine-protein kinase AKL1

1

17

High-throughput

0.647

High

803524

YHI2
Uncharacterized protein YHR022C

1

3

High-throughput

0.647

High

825199

HOS4
Protein HOS4

1

2

High-throughput

0.647

High

865518

FPK1
Flippase kinase 1

1

14

High-throughput

0.647

High

865523

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.647

High

865536

TDA1
Serine/threonine-protein kinase TDA1

1

18

High-throughput

0.647

High

865542

AVO2
Target of rapamycin complex 2 subunit AVO2

1

2

High-throughput

0.647

High

865565

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

19

High-throughput

0.647

High

524426

HSP71
Heat shock protein SSA1

3

19

High-throughput

0.633

High

865558

NOP12
Nucleolar protein 12

1

8

High-throughput

0.618

High

579671

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.618

High

740978

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

5

High-throughput

0.618

High

865495

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

18

High-throughput

0.618

High

754220

MSN4
Zinc finger protein MSN4

1

0

High-throughput

0.614

High

835521

AZF1
Transcription factor AZF1

1

0

High-throughput

0.614

High

820879

SIP5
Protein SIP5

2

3

High-throughput

0.602

High

626798

HSP60
Heat shock protein 60, mitochondrial

2

15

High-throughput

0.602

High

679838

CDC48
Cell division control protein 48

2

10

High-throughput

0.595

High

824474

6P21
6-phosphofructo-2-kinase 1

2

7

High-throughput

0.585

High

678784

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

20

High-throughput

0.579

High

482048

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.536

High

722063

XPO1
Exportin-1

1

8

High-throughput

0.536

High

815161

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.536

High

865574

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

365103

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.501

High

420957

PMA1
Plasma membrane ATPase 1

1

4

Small-scale

0.501

High

446237

PHSG
Glycogen phosphorylase

1

2

High-throughput

0.501

High

558792

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.501

High

625027

PRP6
Pre-mRNA-splicing factor 6

1

4

High-throughput

0.501

High

655589

TKT1
Transketolase 1

1

1

High-throughput

0.501

High

663317

FPS1
Glycerol uptake/efflux facilitator protein

1

9

High-throughput

0.501

High

664314

SSD1
Protein SSD1

1

1

High-throughput

0.501

High

664447

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.501

High

672113

PUF4
Pumilio homology domain family member 4

1

1

High-throughput

0.501

High

693199

PHO91
Low-affinity phosphate transporter PHO91

1

3

High-throughput

0.501

High

702311

MGLL
Monoglyceride lipase

1

2

High-throughput

0.501

High

726580

VATC
V-type proton ATPase subunit C

1

2

High-throughput

0.501

High

732033

MLF3
Protein MLF3

1

1

High-throughput

0.501

High

735941

PSA5
Proteasome subunit alpha type-5

1

6

High-throughput

0.501

High

736492

MDHP
Malate dehydrogenase, peroxisomal

1

3

High-throughput

0.501

High

740305

PAH1
Phosphatidic acid phosphohydrolase 1

1

3

High-throughput

0.501

High

745092

AFG2
ATPase family gene 2 protein

1

10

High-throughput

0.501

High

746643

DRS1
ATP-dependent RNA helicase DRS1

1

9

High-throughput

0.501

High

746740

KPR1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.501

High

752025

PGM1
Phosphoglucomutase 1

1

1

High-throughput

0.501

High

757893

UBX1
UBX domain-containing protein 1

1

2

High-throughput

0.501

High

762709

UBL1
Ubiquitin carboxyl-terminal hydrolase YUH1

1

4

High-throughput

0.501

High

781544

ALY1
Arrestin-related trafficking adapter 6

1

5

High-throughput

0.501

High

782654

PXL1
Paxillin-like protein 1

1

6

High-throughput

0.501

High

789804

SOL2
6-phosphogluconolactonase-like protein 2

1

1

High-throughput

0.501

High

790452

PAM1
Protein PAM1

1

1

High-throughput

0.501

High

802840

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

1

High-throughput

0.501

High

806040

KEL1
Kelch repeat-containing protein 1

1

3

High-throughput

0.501

High

808732

ITS3
Phosphatidylinositol 4-phosphate 5-kinase MSS4

1

6

High-throughput

0.501

High

810977

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.501

High

812848

PHO90
Low-affinity phosphate transporter PHO90

1

2

High-throughput

0.501

High

815490

RSP5
E3 ubiquitin-protein ligase RSP5

1

10

High-throughput

0.501

High

817548

ICP55
Intermediate cleaving peptidase 55

1

2

High-throughput

0.501

High

824687

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

824846

NDC80
Kinetochore protein NDC80

1

20

High-throughput

0.501

High

824965

VHS2
Protein VHS2

1

1

High-throughput

0.501

High

825694

SER33
D-3-phosphoglycerate dehydrogenase 2

1

2

High-throughput

0.501

High

844397

YG4I
Uncharacterized GTP-binding protein YGR210C

1

3

High-throughput

0.501

High

849611

AQY3
Aquaglycerol porin AQY3

1

9

High-throughput

0.501

High

849619

ALR2
Magnesium transporter ALR2

1

2

High-throughput

0.501

High

858272

ARC1
tRNA-aminoacylation cofactor ARC1

1

4

High-throughput

0.501

High

864259

ALY2
Arrestin-related trafficking adapter 3

1

5

High-throughput

0.501

High

865497

MET7
Cystathionine gamma-synthase

1

1

High-throughput

0.501

High

865498

GYP3
GTPase-activating protein GYP3

1

2

High-throughput

0.501

High

865499

SF3B1
U2 snRNP component HSH155

1

11

High-throughput

0.501

High

865505

MGA1
Protein MGA1

1

7

High-throughput

0.501

High

865507

HUL5
E3 ubiquitin-protein ligase HUL5

1

12

High-throughput

0.501

High

865511

GYP2
GTPase-activating protein GYP2

1

2

High-throughput

0.501

High

865515

REXO1
RNA exonuclease 1

1

3

High-throughput

0.501

High

865520

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.501

High

865522

ESBP6
Uncharacterized transporter ESBP6

1

5

High-throughput

0.501

High

865524

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

3

High-throughput

0.501

High

865533

NGL2
RNA exonuclease NGL2

1

1

High-throughput

0.501

High

865534

GCN5
Histone acetyltransferase GCN5

1

7

High-throughput

0.501

High

865538

ENT5
Epsin-5

1

2

High-throughput

0.501

High

865540

YM54
Uncharacterized protein YMR196W

1

2

High-throughput

0.501

High

865541

ASND1
Asparagine synthetase domain-containing protein YML096W

1

2

High-throughput

0.501

High

865545

YTH1
mRNA 3'-end-processing protein YTH1

1

1

High-throughput

0.501

High

865546

RGC1
Regulator of the glycerol channel 1

1

3

High-throughput

0.501

High

865548

YL257
Uncharacterized protein YLR257W

1

1

High-throughput

0.501

High

865552

BDF2
Bromodomain-containing factor 2

1

10

High-throughput

0.501

High

865555

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

1

High-throughput

0.501

High

865556

ENT4
Epsin-4

1

2

High-throughput

0.501

High

865559

ALR1
Magnesium transporter ALR1

1

2

High-throughput

0.501

High

865560

GYP1
GTPase-activating protein GYP1

1

3

High-throughput

0.501

High

865561

LKHA4
Leucine aminopeptidase 2

1

1

High-throughput

0.501

High

865564

WTM2
Transcriptional modulator WTM2

1

1

High-throughput

0.501

High

865567

WTM1
Transcriptional modulator WTM1

1

1

High-throughput

0.501

High

865568

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

3

High-throughput

0.501

High

150337

DIF1
Damage-regulated import facilitator 1

1

0

High-throughput

0.480

High

470055

DCOR
Ornithine decarboxylase

1

0

High-throughput

0.480

High

470653

ERG20
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.480

High

599665

STF2
ATPase-stabilizing factor 15 kDa protein

1

0

High-throughput

0.480

High

613743

MET16
Phosphoadenosine phosphosulfate reductase

1

0

High-throughput

0.480

High

626571

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.480

High

633227

KICH
Choline kinase

1

0

High-throughput

0.480

High

638035

UTR1
NAD(+) kinase

1

0

High-throughput

0.480

High

692515

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.480

High

735434

TREA
Cytosolic neutral trehalase

1

0

High-throughput

0.480

High

738546

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.480

High

763537

ATG19
Autophagy-related protein 19

1

0

High-throughput

0.480

High

780965

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.480

High

781568

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.480

High

781977

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.480

High

806888

SET5
Histone-lysine N-methyltransferase SET5

1

0

High-throughput

0.480

High

808852

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.480

High

813389

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.480

High

822223

SECU
Securin

1

0

High-throughput

0.480

High

823328

YJH0
Inactive deaminase YJL070C

1

0

High-throughput

0.480

High

828612

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.480

High

835537

BUD6
Bud site selection protein 6

1

0

High-throughput

0.480

High

850403

IGD1
Inhibitor of glycogen debranching 1

1

0

High-throughput

0.480

High

850714

RMD8
Sporulation protein RMD8

1

0

High-throughput

0.480

High

863245

IDS2
IME2-dependent-signaling protein

1

0

High-throughput

0.480

High

864152

MTC1
Maintenance of telomere capping protein 1

1

0

High-throughput

0.480

High

865489

YJ26
Uncharacterized protein YJR056C

1

0

High-throughput

0.480

High

865496

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.480

High

865500

PSP1
Protein PSP1

1

0

High-throughput

0.480

High

865502

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.480

High

865506

NIF3
NGG1-interacting factor 3

1

0

High-throughput

0.480

High

865508

NPY1
NAD-capped RNA hydrolase NPY1

1

0

High-throughput

0.480

High

865509

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.480

High

865512

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

1

0

High-throughput

0.480

High

865513

AP18B
Clathrin coat assembly protein AP180B

1

0

High-throughput

0.480

High

865514

YG5L
Uncharacterized protein YGR266W

1

0

High-throughput

0.480

High

865525

SKO1
CRE-binding bZIP protein SKO1

1

0

High-throughput

0.480

High

865529

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.480

High

865532

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.480

High

865544

HRI1
Protein HRI1

1

0

High-throughput

0.480

High

865549

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.480

High

865550

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.480

High

865553

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.480

High

865554

HBT1
Protein HBT1

1

0

High-throughput

0.480

High

865557

CMS1
Protein CMS1

1

0

High-throughput

0.480

High

865563

TIP41
Type 2A phosphatase activator TIP41

1

0

High-throughput

0.480

High

865569

WHI5
G1-specific transcriptional repressor WHI5

1

0

High-throughput

0.480

High

865570

STB3
Protein STB3

1

0

High-throughput

0.480

High

865572

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.480

High

368005

ENO2
Enolase 2

1

2

High-throughput

0.479

High

444561

DED1
ATP-dependent RNA helicase DED1

1

3

High-throughput

0.479

High

510620

HSP77
Import motor subunit, mitochondrial

1

14

High-throughput

0.479

High

527069

HSP72
Heat shock protein SSA2

1

19

High-throughput

0.479

High

707529

TF2B
Transcription initiation factor IIB

1

11

High-throughput

0.479

High

747932

SMY2
Protein SMY2

1

3

High-throughput

0.479

High

752458

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.479

High

763344

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.479

High

795437

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

865503

SAP4
SIT4-associating protein SAP4

1

3

High-throughput

0.479

High

865562

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

818387

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

0

High-throughput

0.458

High

567693

ACOX
Acyl-coenzyme A oxidase

1

1

High-throughput

0.457

High

584317

DPOD
DNA polymerase delta catalytic subunit

1

4

High-throughput

0.457

High

654607

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.457

High

672602

YCR3
Major facilitator superfamily domain-containing protein YCR023C

1

4

High-throughput

0.457

High

734338

DGR2
2-deoxy-glucose resistant protein 2

1

7

High-throughput

0.457

High

740735

SRP40
Suppressor protein SRP40

1

2

High-throughput

0.457

High

757613

TGL1
Sterol esterase TGL1

1

1

High-throughput

0.457

High

776412

MNR2
Manganese resistance protein MNR2

1

2

High-throughput

0.457

High

780529

AVT3
Vacuolar amino acid transporter 3

1

8

High-throughput

0.457

High

793054

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.457

High

797154

AIM3
Altered inheritance of mitochondria protein 3

1

4

High-throughput

0.457

High

801695

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

2

High-throughput

0.457

High

805488

TOM71
Protein TOM71

1

5

High-throughput

0.457

High

825224

SEC24
Protein transport protein SEC24

1

1

High-throughput

0.457

High

825739

MAM33
Mitochondrial acidic protein MAM33

1

4

High-throughput

0.457

High

864461

IRC8
Uncharacterized protein IRC8

1

2

High-throughput

0.457

High

864720

BBC1
Myosin tail region-interacting protein MTI1

1

1

High-throughput

0.457

High

865132

AVT1
Vacuolar amino acid transporter 1

1

9

High-throughput

0.457

High

865501

AVT4
Vacuolar amino acid transporter 4

1

8

High-throughput

0.457

High

865510

ORM1
Protein ORM1

1

3

High-throughput

0.457

High

865516

ARE2
Sterol O-acyltransferase 2

1

1

High-throughput

0.457

High

865526

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

1

High-throughput

0.457

High

865527

YP077
Uncharacterized protein YPL077C

1

1

High-throughput

0.457

High

865530

YMZ2
WD repeat-containing protein YMR102C

1

7

High-throughput

0.457

High

865531

NGL3
Probable RNA exonuclease NGL3

1

1

High-throughput

0.457

High

865537

YMD7
Uncharacterized protein YML037C

1

2

High-throughput

0.457

High

865539

NUP53
Nucleoporin NUP53

1

1

Small-scale

0.457

High

865547

ORM2
Protein ORM2

1

3

High-throughput

0.457

High

865551

NVJ2
Nucleus-vacuole junction protein 2

1

1

High-throughput

0.457

High

865573

RL21B
Large ribosomal subunit protein eL21B

1

1

High-throughput

0.457

High

865575

RS21B
Small ribosomal subunit protein eS21B

1

2

High-throughput

0.457

High

425136

OTC
Ornithine carbamoyltransferase

1

7

High-throughput

0.457

High

804268

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

819155

SSB2
Ribosome-associated molecular chaperone SSB2

1

18

High-throughput

0.445

High

865566

HSP42
Heat shock protein 42

1

3

High-throughput

0.445

High

739683

SPT16
FACT complex subunit SPT16

1

3

Small-scale

0.437

High

812454

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

268888

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.261

Low

439484

CCHL
Holocytochrome-c synthase

1

0

High-throughput

0.261

Low

521087

PT122
Protein PET122, mitochondrial

1

0

High-throughput

0.261

Low

575557

NMT
Glycylpeptide N-tetradecanoyltransferase

1

0

High-throughput

0.261

Low

598573

RGP1
Guanine nucleotide exchange factor subunit RGP1

1

0

High-throughput

0.261

Low

602097

SPO16
Sporulation-specific protein 16

1

0

High-throughput

0.261

Low

636330

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.261

Low

659158

MBR1
Mitochondrial biogenesis regulation protein 1

1

0

High-throughput

0.261

Low

703833

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.261

Low

738006

ISF1
Increasing suppression factor 1

1

0

High-throughput

0.261

Low

750338

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.261

Low

776444

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.261

Low

782679

SKG1
Suppressor of lethality of KEX2 GAS1 double null mutant protein 1

1

0

High-throughput

0.261

Low

796498

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.261

Low

797357

ICS2
Increased copper sensitivity protein 2

1

0

High-throughput

0.261

Low

798534

BIT2
Probable target of rapamycin complex 2 subunit BIT2

1

0

High-throughput

0.261

Low

805277

YPT35
Endosomal/vacuolar adapter protein YPT35

1

0

High-throughput

0.261

Low

806258

SSP1
Sporulation-specific protein 1

1

0

High-throughput

0.261

Low

816941

RRAAH
4-hydroxy-4-methyl-2-oxoglutarate aldolase

1

0

High-throughput

0.261

Low

865448

VPS55
Vacuolar protein sorting-associated protein 55

1

0

High-throughput

0.261

Low

865504

PSD2
Phosphatidylserine decarboxylase proenzyme 2

1

0

High-throughput

0.261

Low

865517

ZRG17
Protein ZRG17

1

0

High-throughput

0.261

Low

865519

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.261

Low

865521

BNI5
Bud neck protein 5

1

0

High-throughput

0.261

Low

865528

ATG21
Autophagy-related protein 21

1

0

High-throughput

0.261

Low

865543

IVY1
Protein IVY1

1

0

High-throughput

0.261

Low

865571

FMP16
Protein FMP16, mitochondrial

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025