Protein: DIG2
Down-regulator of invasive growth 2 (Regulator of STE12 protein 2) (Regulator of sterile twelve 2)

Gene: DIG2
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: Q03373

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0045894 - negative regulation of mating-type specific transcription, DNA-templated
GO:0071444 - cellular response to pheromone

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

599395

FUS3
Mitogen-activated protein kinase FUS3

9

1

Small-scale

0.757

High

574733

KSS1
Mitogen-activated protein kinase KSS1

7

1

Small-scale

0.751

High

564675

STE12
Protein STE12

9

0

Small-scale

0.725

High

1040659

DIG1
Down-regulator of invasive growth 1

6

0

Small-scale

0.697

High

1039021

IMA1
Importin subunit alpha

2

0

High-throughput

0.598

High

709954

BMH1
Protein BMH1

2

1

High-throughput

0.594

High

760339

BMH2
Protein BMH2

2

1

High-throughput

0.594

High

416912

CDC25
Cell division control protein 25

2

0

High-throughput

0.588

High

393239

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.584

High

579968

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.537

High

656347

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

1

Small-scale

0.536

High

778967

KDX1
Serine/threonine-protein kinase KDX1

1

1

High-throughput

0.536

High

694243

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

722211

XPO1
Exportin-1

1

0

High-throughput

0.513

High

632397

CG11
G1/S-specific cyclin CLN1

1

1

Small-scale

0.508

High

632437

CG12
G1/S-specific cyclin CLN2

1

1

Small-scale

0.508

High

575608

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

1

Small-scale

0.501

High

792441

BOI1
BEM1-interacting protein 1

1

1

High-throughput

0.494

High

816046

BOI2
BEM1-interacting protein 2

1

1

High-throughput

0.494

High

515398

MTAL1
Mating-type protein ALPHA1

1

0

High-throughput

0.486

High

805631

LSM12
Protein LSM12

1

0

High-throughput

0.486

High

1042525

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.486

High

1042526

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.486

High

656852

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

704701

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.480

High

801908

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.480

High

488995

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

555273

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.458

High

575048

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.458

High

613830

TEC1
Ty transcription activator TEC1

1

0

High-throughput

0.458

High

668293

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

713031

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

738774

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.458

High

754241

MSN4
Zinc finger protein MSN4

1

0

High-throughput

0.458

High

763987

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

793580

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

0

High-throughput

0.458

High

798615

PAF1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

863401

RSF2
Respiration factor 2

1

0

High-throughput

0.458

High

893291

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

919132

YG34
Uncharacterized protein YGR122W

1

0

High-throughput

0.458

High

1030396

CTF4
DNA polymerase alpha-binding protein

1

0

High-throughput

0.458

High

1042527

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1042528

PBP4
Protein PBP4

1

0

High-throughput

0.458

High

546062

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

819639

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

524972

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

727280

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

745034

YSC84
Protein YSC84

1

0

High-throughput

0.282

High

805431

BZZ1
Protein BZZ1

1

0

High-throughput

0.282

High

1010268

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

622392

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

858123

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.269

Low

737203

HYM1
Protein HYM1

1

0

High-throughput

0.265

Low

738692

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

802012

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

High-throughput

0.265

Low

864402

BIT61
Target of rapamycin complex 2 subunit BIT61

1

0

High-throughput

0.265

Low

865209

MRX12
MIOREX complex component 12

1

0

High-throughput

0.265

Low

394855

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

626869

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

735439

TREA
Cytosolic neutral trehalase

1

0

High-throughput

0.249

Low

836326

BNI1
Protein BNI1

1

0

High-throughput

0.249

Low

824533

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025