Protein: HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3 (HMG-CoA reductase degradation protein 3)

Gene: HRD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 31
UniProt ID: Q05787

Gene Ontology (top 5):
GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0002235 - detection of unfolded protein
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1052333

OS9
Protein OS-9 homolog

7

0

Small-scale

0.916

High

1052331

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

14

5

Small-scale

0.762

High

680071

CDC48
Cell division control protein 48

5

3

Small-scale

0.709

High

366062

CBPY
Carboxypeptidase Y

6

0

Small-scale

0.694

High

1043820

USA1
U1 SNP1-associating protein 1

5

0

Small-scale

0.678

High

797817

DER1
Degradation in the endoplasmic reticulum protein 1

4

0

Small-scale

0.658

High

754451

NPL4
Nuclear protein localization protein 4

2

1

Small-scale

0.611

High

1052332

DFM1
DER1-like family member protein 1

2

3

Small-scale

0.611

High

1046146

UBX2
UBX domain-containing protein 2

3

0

Small-scale

0.606

High

554376

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

Small-scale

0.536

High

554449

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

Small-scale

0.536

High

816218

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.518

High

924918

YNJ5
Uncharacterized transporter YNL095C

1

0

High-throughput

0.518

High

748545

SC61A
Protein transport protein SEC61

1

0

Small-scale

0.513

High

734385

OAC1
Mitochondrial oxaloacetate transport protein

1

4

High-throughput

0.494

High

597278

BIP
Endoplasmic reticulum chaperone BiP

1

5

Small-scale

0.479

High

671712

SCJ1
DnaJ-related protein SCJ1

1

5

Small-scale

0.479

High

735360

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

0

Small-scale

0.458

High

780803

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

865256

YJY5
Uncharacterized endoplasmic reticulum membrane protein YJR015W

1

0

High-throughput

0.458

High

916747

UFD1
Ubiquitin fusion degradation protein 1

1

0

High-throughput

0.458

High

1035098

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.457

High

676355

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

1052330

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

4

High-throughput

0.445

High

580079

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.437

High

525164

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.407

High

527690

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.407

High

546295

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.407

High

819810

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.407

High

408491

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.249

Low

448406

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025