Protein: UFD1
Ubiquitin fusion degradation protein 1 (UB fusion protein 1) (Polymerase-interacting protein 3)

Gene: UFD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P53044

Gene Ontology (top 5):
GO:0000837 - Doa10p ubiquitin ligase complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006274 - DNA replication termination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

754439

NPL4
Nuclear protein localization protein 4

20

7

Small-scale

0.767

High

679881

CDC48
Cell division control protein 48

22

8

Small-scale

0.766

High

916744

UBX2
UBX domain-containing protein 2

7

0

Small-scale

0.714

High

509649

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

5

6

Small-scale

0.710

High

779956

DOA1
Protein DOA1

3

1

Small-scale

0.656

High

916758

SMT3
Ubiquitin-like protein SMT3

3

1

Small-scale

0.654

High

916751

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

2

3

Small-scale

0.624

High

797814

DER1
Degradation in the endoplasmic reticulum protein 1

2

0

Small-scale

0.602

High

916753

CDC53
Cell division control protein 53

2

1

Small-scale

0.586

High

916740

UFD2
E4 ubiquitin-protein ligase UFD2

2

0

Small-scale

0.585

High

916749

UBX5
UBX domain-containing protein 5

2

2

Small-scale

0.584

High

849717

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.561

High

916741

SLD5
DNA replication complex GINS protein SLD5

2

0

Small-scale

0.559

High

712933

PAP
Poly(A) polymerase

1

0

Small-scale

0.549

High

448464

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.530

High

822264

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

Small-scale

0.530

High

912376

UBA2
Ubiquitin-activating enzyme E1-like

1

0

Small-scale

0.529

High

916742

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.518

High

916761

DFM1
DER1-like family member protein 1

1

1

Small-scale

0.515

High

916760

RQC2
Ribosome quality control complex subunit 2

1

0

Small-scale

0.513

High

916748

PIN3
[PSI+] inducibility protein 3

1

0

High-throughput

0.486

High

664449

MCM3
DNA replication licensing factor MCM3

1

3

Small-scale

0.479

High

707660

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

713010

MCM2
DNA replication licensing factor MCM2

1

3

Small-scale

0.479

High

713283

MCM5
Minichromosome maintenance protein 5

1

3

Small-scale

0.479

High

721390

MCM4
DNA replication licensing factor MCM4

1

4

Small-scale

0.479

High

794085

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.479

High

916737

MCM6
DNA replication licensing factor MCM6

1

3

Small-scale

0.479

High

916750

CDC45
Cell division control protein 45

1

1

Small-scale

0.479

High

739308

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.460

High

780968

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

824852

NDC80
Kinetochore protein NDC80

1

0

High-throughput

0.460

High

916738

PBP1
PAB1-binding protein 1

1

0

Small-scale

0.460

High

916743

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.460

High

916754

ELG1
Telomere length regulation protein ELG1

1

0

Small-scale

0.460

High

916762

HUB1
Ubiquitin-like modifier HUB1

1

0

Small-scale

0.460

High

514030

RL18B
Large ribosomal subunit protein eL18B

1

0

Small-scale

0.458

High

579748

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

603080

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

661809

TOM40
Mitochondrial import receptor subunit TOM40

1

0

Small-scale

0.458

High

741009

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

764197

SPT23
Protein SPT23

1

0

Small-scale

0.458

High

778435

RS27A
Small ribosomal subunit protein eS27A

1

0

Small-scale

0.458

High

823313

PSF2
DNA replication complex GINS protein PSF2

1

0

Small-scale

0.458

High

834783

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.458

High

910760

SKP1
Suppressor of kinetochore protein 1

1

0

High-throughput

0.458

High

916736

UFD1
Ubiquitin fusion degradation protein 1

1

0

High-throughput

0.458

High

916739

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

916745

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

916746

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.458

High

916747

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

0

High-throughput

0.458

High

916757

PSF3
DNA replication complex GINS protein PSF3

1

0

Small-scale

0.458

High

916759

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

916763

OS9
Protein OS-9 homolog

1

0

High-throughput

0.458

High

816965

BIM1
Protein BIM1

1

1

Small-scale

0.439

High

527193

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

554440

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

2

0

Small-scale

0.318

High

805735

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.269

Low

864730

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.265

Low

916752

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.265

Low

916755

NUR1
Nuclear rim protein 1

1

0

Small-scale

0.251

Low

556577

STE6
Alpha-factor-transporting ATPase

1

0

Small-scale

0.249

Low

797580

FZO1
Mitofusin FZO1

1

0

Small-scale

0.249

Low

916756

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

366056

CBPY
Carboxypeptidase Y

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025