Protein: NPL4
Nuclear protein localization protein 4 (HMG-CoA reductase degradation protein 4)

Gene: NPL4
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P33755

Gene Ontology (top 5):
GO:0000837 - Doa10p ubiquitin ligase complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006274 - DNA replication termination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

679539

CDC48
Cell division control protein 48

19

6

Small-scale

0.988

High

509477

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

6

3

Small-scale

0.956

High

754439

UFD1
Ubiquitin fusion degradation protein 1

20

7

Small-scale

0.767

High

754448

UBX2
UBX domain-containing protein 2

6

0

Small-scale

0.699

High

754444

UFD2
E4 ubiquitin-protein ligase UFD2

4

0

Small-scale

0.669

High

754453

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

3

1

Small-scale

0.664

High

754452

UBX5
UBX domain-containing protein 5

3

2

Small-scale

0.646

High

754426

DOA1
Protein DOA1

2

1

Small-scale

0.611

High

754451

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

2

1

Small-scale

0.611

High

754442

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

1

Small-scale

0.601

High

754422

NPL4
Nuclear protein localization protein 4

1

0

High-throughput

0.586

High

754429

DER1
Degradation in the endoplasmic reticulum protein 1

2

0

Small-scale

0.585

High

754449

VMS1
tRNA endonuclease VMS1

2

0

Small-scale

0.576

High

439305

PDC1
Pyruvate decarboxylase isozyme 1

2

0

High-throughput

0.563

High

754437

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.561

High

754459

DFM1
DER1-like family member protein 1

1

2

Small-scale

0.536

High

754450

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.513

High

754458

RQC2
Ribosome quality control complex subunit 2

1

0

Small-scale

0.513

High

754424

SPT23
Protein SPT23

1

1

Small-scale

0.501

High

754435

MGA2
Protein MGA2

1

1

Small-scale

0.501

High

704583

SBA1
Co-chaperone protein SBA1

1

0

High-throughput

0.493

High

754454

CDC53
Cell division control protein 53

1

1

Small-scale

0.481

High

692320

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.480

High

754430

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.480

High

754423

UBX1
UBX domain-containing protein 1

1

5

High-throughput

0.479

High

754428

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.479

High

603035

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

670540

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

706673

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

740853

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

754425

CENPA
Histone H3-like centromeric protein CSE4

1

0

Small-scale

0.458

High

754432

DDI1
DNA damage-inducible protein 1

1

0

Small-scale

0.458

High

754434

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

Small-scale

0.458

High

754436

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.458

High

754443

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

754446

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.458

High

754455

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

754456

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.458

High

754431

PCF11
Protein PCF11

1

0

High-throughput

0.438

High

754445

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

754447

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.438

High

754457

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

394416

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

592150

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

754433

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.426

High

737285

HXT4
Low-affinity glucose transporter HXT4

1

1

High-throughput

0.407

High

754440

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

554411

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

Small-scale

0.249

Low

556566

STE6
Alpha-factor-transporting ATPase

1

0

Small-scale

0.249

Low

754427

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

754438

PT130
Protein PET130

1

0

High-throughput

0.249

Low

754441

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025