Protein: SPF1
Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Complexed with DOR1 protein 1) (Endoplasmic reticulum P5A-ATPase) (Sensitivity to the P.farinosa killer toxin protein 1)

Gene: SPF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 83
UniProt ID: P39986

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005801 - cis-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579451

HSC82
ATP-dependent molecular chaperone HSC82

2

5

High-throughput

0.584

High

748407

SC61A
Protein transport protein SEC61

2

2

High-throughput

0.584

High

796943

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.584

High

524047

HSP71
Heat shock protein SSA1

2

5

Small-scale

0.571

High

365629

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.563

High

367974

ENO2
Enolase 2

2

0

High-throughput

0.563

High

526775

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

816218

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

0

High-throughput

0.518

High

382913

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

392784

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

417105

VDAC1
Non-selective voltage-gated ion channel 1

1

3

Small-scale

0.479

High

448731

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.479

High

547055

PPB
Repressible alkaline phosphatase

1

1

Small-scale

0.479

High

554348

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

High-throughput

0.479

High

554428

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.479

High

577138

SEC63
Protein translocation protein SEC63

1

3

High-throughput

0.479

High

636312

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.479

High

656783

KC12
Casein kinase I homolog 2

1

2

Small-scale

0.479

High

677105

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

679720

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

726090

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

727053

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

745342

EMP24
Endosomal protein P24B

1

6

High-throughput

0.479

High

754693

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

High-throughput

0.479

High

780755

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

1

High-throughput

0.479

High

798645

SSH1
Sec sixty-one protein homolog

1

2

High-throughput

0.479

High

803553

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

812039

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

816191

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

Small-scale

0.479

High

816192

ELO3
Fatty acid elongase 3

1

4

High-throughput

0.479

High

816196

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

816197

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.479

High

816199

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

Small-scale

0.479

High

816201

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

816204

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

816214

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

816220

RTK1
Probable serine/threonine-protein kinase RTK1

1

3

Small-scale

0.479

High

816221

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

2

High-throughput

0.479

High

428006

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

Small-scale

0.458

High

439525

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

678008

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

735309

ERG2
C-8 sterol isomerase ERG2

1

0

High-throughput

0.458

High

735836

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

Small-scale

0.458

High

754399

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

782209

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.458

High

798094

OM14
Mitochondrial outer membrane protein OM14

1

0

Small-scale

0.458

High

802481

LAG1
Ceramide synthase LAG1

1

0

High-throughput

0.458

High

804797

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

812324

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

816194

LCB2
Serine palmitoyltransferase 2

1

0

High-throughput

0.458

High

816195

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

816198

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.458

High

816203

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.458

High

816205

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.458

High

816207

YG5L
Uncharacterized protein YGR266W

1

0

Small-scale

0.458

High

816208

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

816209

ESP1
Separin

1

0

High-throughput

0.458

High

816213

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

816216

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

816217

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

816222

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

544984

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

741641

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

816190

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

670748

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

707183

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

709781

BMH1
Protein BMH1

1

2

High-throughput

0.437

High

758447

YKK0
Probable intramembrane protease YKL100C

1

6

High-throughput

0.437

High

795001

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

806720

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

816210

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

816212

SXM1
Importin beta SMX1

1

3

High-throughput

0.437

High

780106

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

816211

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.282

High

676933

SRO9
RNA-binding protein SRO9

1

0

Small-scale

0.249

Low

677409

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

796657

IST2
Increased sodium tolerance protein 2

1

0

Small-scale

0.249

Low

816193

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

816206

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

816215

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

816219

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

816200

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

816202

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025