Protein: ERG3
Delta(7)-sterol 5(6)-desaturase ERG3 (EC 1.14.19.20) (C-5 sterol desaturase ERG3) (Ergosterol Delta(5,6) desaturase ERG3) (Ergosterol biosynthetic protein 3) (Sterol-C5-desaturase)

Gene: ERG3
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: P32353

Gene Ontology (top 5):
GO:0000248 - C-5 sterol desaturase activity
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

735349

ERG25
C-4 methylsterol oxidase ERG25

2

4

Small-scale

0.632

High

735325

ERG24
Delta(14)-sterol reductase ERG24

2

1

Small-scale

0.614

High

735338

ERG28
Ergosterol biosynthetic protein 28

2

2

Small-scale

0.614

High

528564

CP51
Lanosterol 14-alpha demethylase CYP51

2

3

Small-scale

0.576

High

668887

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

715026

ERG9
Squalene synthase ERG9

1

1

Small-scale

0.541

High

735324

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

4

High-throughput

0.541

High

735332

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.541

High

735334

ERG7
Lanosterol synthase ERG7

1

1

Small-scale

0.541

High

735350

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

2

Small-scale

0.541

High

735354

TMEDA
Endoplasmic reticulum vesicle protein 25

1

6

High-throughput

0.541

High

735365

ERG27
3-keto-steroid reductase ERG27

1

1

Small-scale

0.541

High

735335

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

735364

SMF3
Iron transporter SMF3

1

0

High-throughput

0.518

High

735363

TPO1
Polyamine transporter 1

1

3

High-throughput

0.494

High

735326

ERG1
Squalene epoxidase ERG1

1

1

High-throughput

0.479

High

735331

PHO88
SRP-independent targeting protein 3

1

2

High-throughput

0.479

High

735333

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

1

High-throughput

0.479

High

735339

CYB5
Cytochrome b5

1

5

High-throughput

0.479

High

735340

ELO3
Fatty acid elongase 3

1

6

High-throughput

0.479

High

735347

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

735358

GSF2
Glucose-signaling factor 2

1

2

High-throughput

0.479

High

735359

RTN1
Reticulon-like protein 1

1

1

High-throughput

0.479

High

735366

ENV10
SRP-independent targeting protein 2

1

2

High-throughput

0.479

High

735345

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

735346

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

735360

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

0

Small-scale

0.458

High

735362

ORM2
Protein ORM2

1

2

High-throughput

0.457

High

735351

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

735357

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

735361

IMB1
Importin subunit beta-1

1

1

High-throughput

0.437

High

481528

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.407

High

510292

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

523334

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.407

High

526156

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.407

High

544137

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.407

High

735328

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

735336

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

735337

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.407

High

735348

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

646336

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.249

Low

706470

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

735327

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

735329

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

735330

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

735342

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.249

Low

735343

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

735344

COPB
Coatomer subunit beta

1

0

High-throughput

0.249

Low

735352

BRE5
UBP3-associated protein BRE5

1

0

Small-scale

0.249

Low

735355

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.249

Low

735356

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

653836

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low

675804

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

735341

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low

735353

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025