Protein: HIR1
Protein HIR1 (Histone transcription regulator 1)

Gene: HIR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 59
UniProt ID: P32479

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000417 - HIR complex
GO:0000775 - chromosome, centromeric region
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

689846

ASF1
Histone chaperone ASF1

8

18

Small-scale

0.968

High

690827

HIR2
Protein HIR2

6

17

Small-scale

0.943

High

690826

HIR1
Protein HIR1

3

16

Small-scale

0.839

High

542111

CYC8
General transcriptional corepressor CYC8

1

12

Small-scale

0.740

High

690854

HPC2
Histone promoter control protein 2

6

7

Small-scale

0.727

High

690844

HIR3
Histone transcription regulator 3

4

3

Small-scale

0.683

High

690852

H3
Histone H3

4

20

Small-scale

0.672

High

356326

H4
Histone H4

3

13

Small-scale

0.633

High

690839

UTP7
U3 small nucleolar RNA-associated protein 7

1

18

High-throughput

0.618

High

690834

SPT10
Protein SPT10

1

3

High-throughput

0.618

High

690838

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

11

High-throughput

0.618

High

690864

CMR1
DNA damage-binding protein CMR1

1

19

High-throughput

0.618

High

690841

RT106
Histone chaperone RTT106

2

3

Small-scale

0.594

High

690829

SWI3
SWI/SNF complex subunit SWI3

2

15

Small-scale

0.588

High

690832

TFC4
Transcription factor tau 131 kDa subunit

1

7

High-throughput

0.575

High

690835

SET3
SET domain-containing protein 3

1

20

High-throughput

0.575

High

690850

ARP5
Actin-related protein 5

1

7

High-throughput

0.575

High

690851

ACT
Actin

1

6

High-throughput

0.575

High

690858

ARP9
Actin-like protein ARP9

1

7

High-throughput

0.575

High

690861

ARP8
Actin-like protein ARP8

1

9

High-throughput

0.575

High

490647

HSP71
Heat shock protein SSA1

2

14

High-throughput

0.571

High

690833

MAC1
Metal-binding activator 1

1

0

Small-scale

0.549

High

577137

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

11

Small-scale

0.515

High

603286

SNF2
Transcription regulatory protein SNF2

1

20

Small-scale

0.515

High

690845

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

2

High-throughput

0.500

High

690831

SPT4
Transcription elongation factor SPT4

1

0

Small-scale

0.493

High

365981

HSP82
ATP-dependent molecular chaperone HSP82

1

13

High-throughput

0.479

High

624675

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.479

High

633041

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.479

High

690828

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.479

High

690830

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

7

High-throughput

0.479

High

690846

TAF4
Transcription initiation factor TFIID subunit 4

1

8

High-throughput

0.479

High

690849

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.479

High

690856

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.479

High

539918

RAD9
DNA repair protein RAD9

1

0

Small-scale

0.458

High

378314

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

355396

H2B1
Histone H2B.1

1

14

High-throughput

0.445

High

355827

H2B2
Histone H2B.2

1

14

High-throughput

0.445

High

392348

H2A2
Histone H2A.2

1

10

High-throughput

0.445

High

510617

SSB1
Ribosome-associated molecular chaperone SSB1

1

17

High-throughput

0.445

High

690840

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

690842

RSC8
Chromatin structure-remodeling complex protein RSC8

1

13

High-throughput

0.445

High

690847

INO80
Chromatin-remodeling ATPase INO80

1

20

High-throughput

0.445

High

690853

CDC14
Tyrosine-protein phosphatase CDC14

1

2

High-throughput

0.445

High

690855

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.445

High

690857

DPB4
DNA polymerase epsilon subunit D

1

3

High-throughput

0.445

High

690860

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

20

High-throughput

0.445

High

690862

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.445

High

690863

RLF2
Chromatin assembly factor 1 subunit p90

1

12

High-throughput

0.445

High

367854

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.437

High

543391

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.437

High

660779

HIBCH
Small ribosomal subunit protein mS47

1

2

High-throughput

0.437

High

690836

KMO
Kynurenine 3-monooxygenase

1

2

High-throughput

0.437

High

690848

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.426

High

690859

IES4
Ino eighty subunit 4

1

0

High-throughput

0.426

High

690843

NET1
Nucleolar protein NET1

1

2

High-throughput

0.407

High

690837

GAA1
GPI transamidase component GAA1

1

0

High-throughput

0.249

Low

539530

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024