Protein: LEU3
3-isopropylmalate dehydrogenase (3-IPM-DH) (IMDH) (EC 1.1.1.85) (Beta-IPM dehydrogenase)

Gene: LEU3, LEU2
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: P04173

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003862 - 3-isopropylmalate dehydrogenase activity
GO:0005829 - cytosol
GO:0006097 - glyoxylate cycle
GO:0009098 - L-leucine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

405017

PHO85
Cyclin-dependent protein kinase PHO85

2

6

High-throughput

0.550

High

404995

KAPC
cAMP-dependent protein kinase type 3

1

3

High-throughput

0.500

High

404997

KAPB
cAMP-dependent protein kinase type 2

1

2

High-throughput

0.500

High

404999

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

1

High-throughput

0.500

High

405006

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.500

High

405010

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.500

High

405014

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.500

High

405021

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.500

High

405028

MDHC
Malate dehydrogenase, cytoplasmic

1

6

High-throughput

0.500

High

405030

NPR1
Nitrogen permease reactivator protein

1

3

High-throughput

0.500

High

405033

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

4

High-throughput

0.500

High

405034

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

4

High-throughput

0.500

High

405039

RV161
Reduced viability upon starvation protein 161

1

3

High-throughput

0.500

High

405048

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.500

High

405059

MKK2
MAP kinase kinase MKK2/SSP33

1

4

High-throughput

0.500

High

405060

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.500

High

405075

GBLP
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.500

High

405080

IMB2
Importin subunit beta-2

1

4

High-throughput

0.500

High

405092

PEX7
Peroxisomal targeting signal 2 receptor

1

12

High-throughput

0.500

High

405101

MET18
DNA repair/transcription protein MET18/MMS19

1

2

High-throughput

0.500

High

405102

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.500

High

405107

ATG18
Autophagy-related protein 18

1

4

High-throughput

0.500

High

405108

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.500

High

405115

RPN14
26S proteasome regulatory subunit RPN14

1

11

High-throughput

0.500

High

405118

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.500

High

405119

SSK2
MAP kinase kinase kinase SSK2

1

1

High-throughput

0.500

High

405125

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

1

High-throughput

0.500

High

405128

2ABA
Protein phosphatase PP2A regulatory subunit B

1

1

High-throughput

0.500

High

405129

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

High-throughput

0.500

High

405130

AP1M1
AP-1 complex subunit mu-1-I

1

3

High-throughput

0.500

High

405134

TRM82
tRNA

1

7

High-throughput

0.500

High

405146

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

6

High-throughput

0.500

High

405149

SHS1
Seventh homolog of septin 1

1

2

High-throughput

0.500

High

405161

AP2M
AP-2 complex subunit mu

1

3

High-throughput

0.500

High

404994

GAL1
Galactokinase

1

0

High-throughput

0.479

High

405004

CYAA
Adenylate cyclase

1

0

High-throughput

0.479

High

405029

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.479

High

405064

MSS4
Protein DSS4

1

0

High-throughput

0.479

High

405073

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.479

High

405082

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

405099

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.479

High

405121

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.479

High

405150

PSR1
Phosphatase PSR1

1

0

High-throughput

0.479

High

391949

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.479

High

405013

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.479

High

405045

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

405139

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

404996

CDC7
Cell division control protein 7

1

11

High-throughput

0.457

High

405000

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.457

High

405001

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

405002

PBS2
MAP kinase kinase PBS2

1

5

High-throughput

0.457

High

405003

SPS1
Sporulation-specific protein 1

1

1

High-throughput

0.457

High

405008

HAP3
Transcriptional activator HAP3

1

1

High-throughput

0.457

High

405009

KSS1
Mitogen-activated protein kinase KSS1

1

5

High-throughput

0.457

High

405011

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

2

High-throughput

0.457

High

405012

AMPL
Vacuolar aminopeptidase 1

1

1

High-throughput

0.457

High

405015

TUP1
General transcriptional corepressor TUP1

1

5

High-throughput

0.457

High

405016

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.457

High

405019

GBB
Guanine nucleotide-binding protein subunit beta

1

4

High-throughput

0.457

High

405020

CDC42
Cell division control protein 42

1

3

High-throughput

0.457

High

405022

PRP6
Pre-mRNA-splicing factor 6

1

2

High-throughput

0.457

High

405023

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

4

High-throughput

0.457

High

405025

PP11
Serine/threonine-protein phosphatase PP1-1

1

3

High-throughput

0.457

High

405032

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.457

High

405036

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.457

High

405038

CDC10
Cell division control protein 10

1

1

High-throughput

0.457

High

405040

DMC1
Meiotic recombination protein DMC1

1

2

High-throughput

0.457

High

405041

GID7
GID complex subunit 7

1

4

High-throughput

0.457

High

405043

PWP2
Periodic tryptophan protein 2

1

5

High-throughput

0.457

High

405047

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

1

High-throughput

0.457

High

405049

NTH1
Endonuclease III homolog 1

1

1

High-throughput

0.457

High

405051

DBF20
Serine/threonine-protein kinase DBF20

1

5

High-throughput

0.457

High

405053

KNS1
Dual specificity protein kinase KNS1

1

1

High-throughput

0.457

High

405054

ARP2
Actin-related protein 2

1

1

High-throughput

0.457

High

405058

HIR1
Protein HIR1

1

3

High-throughput

0.457

High

405061

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

2

High-throughput

0.457

High

405062

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.457

High

405065

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.457

High

405066

KU70
ATP-dependent DNA helicase II subunit 1

1

3

High-throughput

0.457

High

405067

PRS6B
26S proteasome regulatory subunit 6B homolog

1

6

High-throughput

0.457

High

405070

DCA13
Protein SOF1

1

4

High-throughput

0.457

High

405071

SIP2
SNF1 protein kinase subunit beta-2

1

2

High-throughput

0.457

High

405074

CAF4
CCR4-associated factor 4

1

8

High-throughput

0.457

High

405076

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.457

High

405077

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.457

High

405078

AP3M
AP-3 complex subunit mu

1

3

High-throughput

0.457

High

405081

SIF2
SIR4-interacting protein SIF2

1

5

High-throughput

0.457

High

405083

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.457

High

405084

RCK2
Serine/threonine-protein kinase RCK2

1

4

High-throughput

0.457

High

405085

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.457

High

405089

TEM1
Protein TEM1

1

3

High-throughput

0.457

High

405090

DUN1
DNA damage response protein kinase DUN1

1

3

High-throughput

0.457

High

405091

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.457

High

405094

RBG1
Ribosome-interacting GTPase 1

1

1

High-throughput

0.457

High

405096

HAT2
Histone acetyltransferase type B subunit 2

1

8

High-throughput

0.457

High

405104

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

1

High-throughput

0.457

High

405105

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

5

High-throughput

0.457

High

405106

COPB2
Coatomer subunit beta'

1

8

High-throughput

0.457

High

405113

INP52
Polyphosphatidylinositol phosphatase INP52

1

1

High-throughput

0.457

High

405116

CDH1
APC/C activator protein CDH1

1

7

High-throughput

0.457

High

405117

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.457

High

405120

COPA
Coatomer subunit alpha

1

8

High-throughput

0.457

High

405123

RHO5
GTP-binding protein RHO5

1

4

High-throughput

0.457

High

405124

CBK1
Serine/threonine-protein kinase CBK1

1

4

High-throughput

0.457

High

405135

VHS1
Serine/threonine-protein kinase VHS1

1

2

High-throughput

0.457

High

405136

WDR59
Maintenance of telomere capping protein 5

1

11

High-throughput

0.457

High

405138

UTP5
U3 small nucleolar RNA-associated protein 5

1

6

High-throughput

0.457

High

405141

KU80
ATP-dependent DNA helicase II subunit 2

1

3

High-throughput

0.457

High

405143

ERB1
Ribosome biogenesis protein ERB1

1

4

High-throughput

0.457

High

405147

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

5

High-throughput

0.457

High

405148

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.457

High

405151

RBX1
RING-box protein HRT1

1

1

High-throughput

0.457

High

405152

YTM1
Ribosome biogenesis protein YTM1

1

4

High-throughput

0.457

High

405154

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

405157

HRT3
F-box protein HRT3

1

1

High-throughput

0.457

High

405159

PRP46
Pre-mRNA-splicing factor PRP46

1

8

High-throughput

0.457

High

405160

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.457

High

382767

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.437

High

405046

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.437

High

405052

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.437

High

405109

SMC3
Structural maintenance of chromosomes protein 3

1

1

Small-scale

0.437

High

405112

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.437

High

405153

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

405156

SMC4
Structural maintenance of chromosomes protein 4

1

1

Small-scale

0.437

High

405100

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

404998

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

405005

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.261

Low

405007

SRS2
ATP-dependent DNA helicase SRS2

1

0

High-throughput

0.261

Low

405018

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.261

Low

405024

FKBP
FK506-binding protein 1

1

0

High-throughput

0.261

Low

405026

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.261

Low

405027

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.261

Low

405031

SAN1
Protein SAN1

1

0

High-throughput

0.261

Low

405035

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.261

Low

405037

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.261

Low

405042

DPO4
DNA polymerase IV

1

0

High-throughput

0.261

Low

405044

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

High-throughput

0.261

Low

405050

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.261

Low

405055

SFP1
Transcription factor SFP1

1

0

High-throughput

0.261

Low

405056

CDC3
Cell division control protein 3

1

0

High-throughput

0.261

Low

405057

HYM1
Protein HYM1

1

0

High-throughput

0.261

Low

405063

FIMB
Fimbrin

1

0

High-throughput

0.261

Low

405068

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.261

Low

405069

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.261

Low

405072

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.261

Low

405079

LSM2
LSM complex subunit LSM2

1

0

High-throughput

0.261

Low

405086

TRM5
tRNA

1

0

High-throughput

0.261

Low

405087

RAD55
DNA repair protein RAD55

1

0

High-throughput

0.261

Low

405093

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.261

Low

405095

SLN1
Osmosensing histidine protein kinase SLN1

1

0

High-throughput

0.261

Low

405097

PTP3
Tyrosine-protein phosphatase 3

1

0

High-throughput

0.261

Low

405098

SECU
Securin

1

0

High-throughput

0.261

Low

405103

PAC11
WD repeat-containing protein PAC11

1

0

High-throughput

0.261

Low

405110

LSM8
LSM2-LSM8 complex subunit LSM8

1

0

High-throughput

0.261

Low

405111

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.261

Low

405114

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.261

Low

405122

ELOA1
Elongin-A

1

0

High-throughput

0.261

Low

405126

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.261

Low

405127

YE066
Putative uncharacterized protein YER066C-A

1

0

High-throughput

0.261

Low

405131

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.261

Low

405132

UME1
Transcriptional regulatory protein UME1

1

0

High-throughput

0.261

Low

405137

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.261

Low

405140

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.261

Low

405142

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.261

Low

405144

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

405155

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.261

Low

405158

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.261

Low

405088

VPS41
Vacuolar protein sorting-associated protein 41

1

0

High-throughput

0.249

Low

405133

ESP1
Separin

1

0

High-throughput

0.249

Low

405145

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025